{"jobs":[{"absolute_url":"https://job-boards.greenhouse.io/treelinebiosciences/jobs/6008073004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5159611004,"location":{"name":"Watertown, Massachusetts, United States"},"metadata":null,"id":6008073004,"updated_at":"2026-05-28T10:24:18-04:00","requisition_id":"2026-14","title":"Director/Sr Director, Chemical Development","company_name":"Treeline Biosciences","first_published":"2026-05-28T10:24:18-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;Treeline Biosciences, a clinical-stage biotechnology company advancing precision medicines, is seeking an experienced Director/SD, Chemical Development to drive the development, scale-up, manufacturing, and regulatory readiness of our small-molecule portfolio. This role will be central to establishing a robust supply chain for our portfolio compounds\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;About the Position\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Director/SD, Chemical Development will have overall responsibility for leading and managing development and manufacturing activities for drug substance, DS intermediates, and starting materials for one or more Treeline programs. The scope of the role encompasses process development, scale-up, and characterization/design space mapping of the manufacturing process of a drug candidate, up to and including process performance qualification (PPQ). Operating within a virtual (100% outsourced) business model, the incumbent will have accountability for CDMO selection and the development of strong and enduring business partnerships supporting assigned programs. The successful candidate will also assume a key leadership role in the development, review, and approval of Module 3 sections of CTD regulatory submissions, written responses to regulatory authorities, and TPP/QTPPs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The successful candidate will be an experienced process chemist with significant experience in CMC development and commercialization of small molecules and an in-depth understanding of critical-path activities and interdisciplinary connections associated with late-phase development and product registration. S/he will possess strong leadership, management and communication skills, ensuring that internal and external business partners understand and respect program goals, objectives, priorities, and timelines.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;br\u0026gt;\u0026lt;strong\u0026gt;Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Lead and manage cross-functional teams engaged in external cGMP manufacturing of drug substance, DS intermediates, and starting materials.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide technical and functional project leadership on drug substance process development, manufacturing, and CDMO partner management.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead and manage process transfers and associated site implementation to support supply chain expansion activities and continuous improvement initiatives.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Monitor, track and trend process performance. Develop and implement data analytics to support investigations and provide an historical baseline for future operational and process-related improvements.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support investigations, root cause identification and CAPA implementation associated with manufacturing deviations and associated quality events.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Work closely with Analytical Development/QC, Quality Assurance, Regulatory CMC, Supply Chain and external manufacturing operations to ensure operational excellence with respect to timelines, budgets, and attainment of technical, regulatory and business goals/milestones.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead the selection of drug substance CDMOs based upon core capabilities, capacity and track record of regulatory compliance; establish KPIs to monitor site technical, quality and business performance.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop and maintain strong relationships with CDMO business partners and participate in Steering Committees as appropriate.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Review/approve technical reports, controlled GMP documents and CMC content for Module 3 CTDs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop and manage scope, milestones, interdependencies, budgets and timelines associated with drug substance program deliverables. Ensure cross-functional alignment of drug substance program deliverables with overall program strategy.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Continuously monitor external business and regulatory environments; identify risks and establish mitigation plans and/or best practices to proactively address Drug Substance and supply chain risk.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Represent the Technical Operations organization in meetings with FDA, EMA and related regulatory authorities.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Ph.D. in Organic Chemistry, Chemical Engineering, or related discipline with a minimum of 12+ years of experience, or Master’s with a minimum of 15+ years of experience in small molecule drug substance development.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Track record of success in leading and managing small-molecule drug substance programs in a 100% outsourced environment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong vendor/supplier management skills and excellent communication and cross-functional collaboration skills.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Competency in developing, implementing and delivering CMC project plans (milestones, timelines, resources, etc.) to successful endpoints.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Expertise in authoring and reviewing technical documents including, but not limited to, development reports, master batch records, analytical testing methods, and specifications.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Thorough knowledge of the drug development process and ICH requirements for NDA and MAA registration. Extensive experience in working with regulatory authorities. Track record of authoring and defending Module 3 CTD content through regulatory approval and commercialization.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to articulate complex issues and ideas with clarity to enable understanding and decision making.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Pragmatic, solution-oriented thinker who possesses a “can do” and “whatever it takes” attitude, coupled with excellent organizational and communication skills.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong interpersonal and decision-making skills with the ability to motivate and influence others, negotiate during situational conflict, and establish the best forward path in the face of competing points of view.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Understanding of industry trends, practices, techniques and standards, and associated impact on program strategy and execution.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to travel (20%) to CDMO domestic and international sites.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Fluency with standard computer software packages (MS Word, Excel, PowerPoint, and Project) and JMP (or similar statistical tools). \u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;High level of personal integrity, commitment to excellence and to our patients.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in developing and commercializing drugs for oncology is preferred\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $229,978 to $277,846. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;\u0026amp;nbsp;\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Recruitment fraud statement\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;We do not conduct interviews through RingCentral, Skype or Telegram.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;You can find more information about job scams at consumer.ftc.gov/articles/job-scams.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;To report job scams, head to ReportFraud.ftc.gov.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;h2\u0026gt;Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)\u0026lt;/h2\u0026gt;\n\u0026lt;p\u0026gt;The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4008714004,"name":"CMC","child_ids":[],"parent_id":4007732004}],"offices":[{"id":4004152004,"name":"Watertown, MA","location":"Watertown, Massachusetts, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/treelinebiosciences/jobs/6008060004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5159603004,"location":{"name":"Watertown, Massachusetts, United States"},"metadata":null,"id":6008060004,"updated_at":"2026-05-28T11:40:46-04:00","requisition_id":"2026-13","title":"Head of Biometrics","company_name":"Treeline Biosciences","first_published":"2026-05-28T11:40:46-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;In your role as \u0026lt;strong\u0026gt;Head of Biometrics\u0026lt;/strong\u0026gt;, you will be responsible for leading all biostatistics and statistical programming activities across Treeline’s clinical and translational development programs. This includes ownership of statistical strategy, clinical trial design, statistical analysis planning, and interpretation of results for regulatory submissions, publications, and decision-making. You will build and manage internal and external biometrics capabilities and ensure the delivery of high-quality, timely, and compliant data outputs to support the advancement of the company’s development pipeline. In close collaboration with clinical development, data management, translational sciences, and regulatory affairs, you will play a critical role in ensuring scientifically rigorous and data-driven development strategies.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Lead and own the statistical strategy across all stages of clinical development, from study design through regulatory submission.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide statistical leadership for protocol design, randomization, sample size determination, and analysis plans.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversee and review statistical deliverables including SAPs, TFLs, integrated summaries, and ad hoc analyses.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborate with cross-functional teams to ensure alignment of biometrics strategy with clinical and regulatory goals.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Serve as the company’s statistical expert in regulatory interactions and ensure compliance with global regulatory standards (FDA, EMA, ICH).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead\u0026amp;nbsp; development of data visualizations, dashboards, analyses, and presentation-ready outputs to support internal decision-making and external presentations for governance meetings, scientific meetings, regulatory interactions, and external partner discussions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Manage the statistical programming function and ensure delivery of high-quality datasets and analysis outputs in support of study reports, submissions, and publications.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Build and lead a high-performing internal biometrics team while managing outsourced CRO partners and statistical consultants.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide leadership in establishing standard operating procedures and data governance best practices for biometrics.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Help shape the broader data strategy and analytics infrastructure in collaboration with clinical data management, clinical operations, and IT.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Required Qualifications:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Advanced degree in Biostatistics, Statistics, Mathematics, or a related field\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;PhD + \u0026amp;gt;10 years relevant industry experience\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;MS + \u0026amp;gt;15 years relevant industry experience\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;li\u0026gt;Proven experience leading biostatistics and/or biometrics functions in biotech or pharmaceutical settings.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong knowledge of statistical methodology, clinical trial design, and regulatory requirements.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Hands-on experience with oncology clinical development strongly preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated success managing external vendors and building biometrics infrastructure in a fast-paced environment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong communication skills with the ability to translate complex statistical issues to non-technical audiences.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Foster a collaborative, solutions-oriented biometrics organization focused on responsiveness, quality and support of stakeholder requests – or serve as strategic partner to senior leadership team, delivering timely biometrics insights and presentation support for high-priority and time-sensitive initiatives.\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strategic thinker with attention to detail, leadership presence, and a commitment to scientific rigor.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown, MA is $310,000 - $395,152. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the job, education, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;\u0026amp;nbsp;\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Recruitment fraud statement\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;We do not conduct interviews through Skype or Telegram. \u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;You can find more information about job scams at consumer.ftc.gov/articles/job-scams.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;To report job scams, head to ReportFraud.ftc.gov.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;h2\u0026gt;Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)\u0026lt;/h2\u0026gt;\n\u0026lt;p\u0026gt;The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4008713004,"name":"Clinical","child_ids":[],"parent_id":4007732004}],"offices":[{"id":4004152004,"name":"Watertown, MA","location":"Watertown, Massachusetts, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/treelinebiosciences/jobs/6010489004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5160807004,"location":{"name":"Watertown, Massachusetts, United States"},"metadata":null,"id":6010489004,"updated_at":"2026-06-05T16:16:36-04:00","requisition_id":"2026-16","title":"Head of Clinical Supply Chain","company_name":"Treeline Biosciences","first_published":"2026-06-05T16:16:36-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;About the role\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are seeking a Head of Clinical Supply Chain to be part of our Technical Operations team. This individual will lead and build the clinical supply chain team and manage end-to-end clinical supply activities for our early and late-stage programs. This position will design, develop, and implement clinical supplies strategies to ensure appropriate continuous supply of material. The successful candidate will work closely with Technical Operations, Clinical Operations, Quality Assurance, Regulatory Affairs, and third-party CMOs.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Provide strategic and operational oversight of Treeline’s clinical supply chain operation\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ensure timely and quality delivery of CTM that meets study protocol, regulatory, and budgetary requirements\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Responsible for all levels of studies, from simple, early-phase programs to complex, multinational, multi-arm studies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop clinical supply forecasts, packaging / labeling requirements, and distribution / return operations in close collaboration with CMC, Clinical Operations, Quality, and Regulatory\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead and manage external consultants and third-party vendors, including collaborating with QA on vendor selection and quality and supplier agreement development.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provides proactive risk identification and mitigation strategies for clinical supply chain.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Identify and directly manage third party vendors for clinical product storage and distribution both within the US and internationally.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead contract negotiation activities from a technical perspective for clinical supply chain vendors\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;In compliance with global regulations, ensure the development and implementation of robust supply chain processes to ensure clinical supply continuity.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead sourcing \u0026amp;amp; distribution of comparator drugs, and matching placebo as needed.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support regulatory filings on an as needed basis.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Effectively communicate progress to internal management and external CDMO partners\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Import / export experience in support of international clinical trials a plus\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Coordinate primary and secondary packaging, labeling, testing, distribution and return drug management activities with CMO\u0026#39;s.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Interface with QA, RA, CMC/manufacturing to ensure trial supplies are appropriately supported including shelf life, quantities, country approvals and specification.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop and manage forecasting and ordering of commercial comparator/combination supplies for global trials\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proactively find solutions to emerging issues in an effective manner while taking into consideration risks and cost-effectiveness.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop new functional SOPs, Policies/Plans as necessary\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Required Qualifications\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Bachelor’s degree in supply chain, life sciences, or a related field with 12 + years of experience in clinical supply chain management in the pharmaceutical industry supporting global clinical trials\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated ability to build and develop a clinical supply chain function in an emerging pharmaceutical company\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience working with third party vendors for IRT setup, IMP storage, and distribution both within the US and internationally.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;In depth knowledge of GMP and global Health Authority requirements.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Comprehensive knowledge of IRT design and management to support clinical supply planning.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;In-depth understanding of medication management and use of advanced simulation tools\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated ability to hire, mentor and develop supply chain managers.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent cross-functional team leadership and project management and presentation skills\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;High level of adaptability in a dynamic and fast-paced environment. Ability to adjust strategies, priorities, and processes in response to changing project needs or stakeholder expectations\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Understanding of budgeting processes and ability to analyze cost effectiveness when defining supply strategies\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated ability to interpret clinical trial drug requests and protocol requirements and translate these into clinical packaging strategies, timelines, and budgets\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborative leader who can influence both business and external partners\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent verbal and written communication skills, with the ability to build productive long-term team relationships at all levels of supplier organizations\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Willingness to travel to various meetings or client sites, domestically or internationally.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown, MA is $231,000 - $325,000. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the job, education, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;\u0026amp;nbsp;\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Recruitment fraud statement\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;We do not conduct interviews through RingCentral, Skype or Telegram.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;You can find more information about job scams at consumer.ftc.gov/articles/job-scams.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;To report job scams, head to ReportFraud.ftc.gov.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;h2\u0026gt;Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)\u0026lt;/h2\u0026gt;\n\u0026lt;p\u0026gt;The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4008714004,"name":"CMC","child_ids":[],"parent_id":4007732004}],"offices":[{"id":4004152004,"name":"Watertown, MA","location":"Watertown, Massachusetts, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/treelinebiosciences/jobs/6002646004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5157602004,"location":{"name":"Watertown, Massachusetts, United States"},"metadata":null,"id":6002646004,"updated_at":"2026-05-22T09:49:41-04:00","requisition_id":"2026-12","title":"Principal / Sr Manager, Clinical Data Management","company_name":"Treeline Biosciences","first_published":"2026-05-22T09:49:41-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;About the Role\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Senior Manager, Clinical Data Management oversees clinical trial data management from startup through database lock, ensuring high-quality, reliable clinical data in support of development programs under the supervision of the Director of Clinical Data Science. This role provides operational leadership across studies, drives data management strategy, manages external vendors, and contributes to process optimization and inspection readiness activities.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Lead and oversee data management activities for assigned clinical trials and programs from study startup through database lock.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partner with CROs and vendors to develop and review Data Management Plans, CRF Completion Guidelines, CRF design, database and edit check specifications, database build and validation, data review plans, data transfer specifications, and database lock activities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversee electronic data capture (EDC) systems and ensure data integrity, consistency, and quality throughout the clinical trial lifecycle.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Manage and oversee external clinical data management vendors and CRO partners, including performance oversight, issue escalation, quality expectations, timelines, and budget considerations. Provide input into vendor selection and governance processes.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead data review and cleaning activities, including query management, reconciliation activities, external data integration, and risk identification.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborate closely with Clinical Operations, Biostatistics, Statistical Programming, Clinical Development, Medical Monitoring, Safety, and Regulatory teams to resolve data-related issues and support study deliverables.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;In collaboration with cross-functional clinical trial team members, drive data management strategies to ensure alignment with overall clinical development goals and program timelines.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop, maintain, and improve SOPs, templates, guidance documents, and operational best practices related to clinical data management.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Identify operational risks and implement mitigation strategies to ensure inspection readiness and compliance with GCP, ICH, and applicable regulatory requirements.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support process improvement initiatives and contribute to the development of scalable, efficient data management operations as the organization grows.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Mentor junior team members and contribute to building data management capabilities across the organization.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Bachelor’s degree in a scientific, healthcare, or related field.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;8+ years of clinical data management experience within the pharmaceutical or biotechnology industry.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Prior experience independently leading data management activities across multiple clinical trials and/or programs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in Oncology clinical development strongly preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong understanding of clinical trial processes, clinical data standards, GCP, ICH guidelines, and regulatory expectations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Hands-on experience with EDC systems, clinical databases, and related clinical technologies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience managing CROs and external vendors, including oversight of deliverables, timelines, and quality.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent organizational, communication, and cross-functional collaboration skills.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to proactively identify issues, drive solutions, and escalate risks appropriately.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated ability to work independently in a fast-paced, collaborative biotech environment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;High level of professionalism, ethical integrity, and commitment to improving outcomes for patients.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown, MA is $180,627 - $208,400. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the job, education, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;\u0026amp;nbsp;\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Recruitment fraud statement\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;We do not conduct interviews through Skype or Telegram. \u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;You can find more information about job scams at consumer.ftc.gov/articles/job-scams.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;To report job scams, head to ReportFraud.ftc.gov.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;h2\u0026gt;Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)\u0026lt;/h2\u0026gt;\n\u0026lt;p\u0026gt;The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4008713004,"name":"Clinical","child_ids":[],"parent_id":4007732004}],"offices":[{"id":4004152004,"name":"Watertown, MA","location":"Watertown, Massachusetts, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/treelinebiosciences/jobs/5830234004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5065039004,"location":{"name":"San Diego, California, United States"},"metadata":null,"id":5830234004,"updated_at":"2026-03-17T10:30:18-04:00","requisition_id":"2026-06","title":"Senior Scientist, Biophysics ","company_name":"Treeline Biosciences","first_published":"2026-03-17T10:30:18-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Senior Scientist Biophysics\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;About the Role\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are seeking an experienced, self-starter, and highly motivated Biophysics Senior Scientists to join our San Diego team to deliver high-quality results and drive small molecule drug discovery. In this role, you will be a key contributor to our small‑molecule discovery engine, designing and executing biophysical strategies that identify high‑quality hits, elucidate mechanisms of action, and accelerate lead optimization. You will work at the center of multidisciplinary project teams, partnering closely with chemistry, biology, and lead discovery to advance programs toward development candidates. The successful candidate will propose, design, and implement new biophysical assays and hit ID approaches (ie. SPR, MST, DSF, NMR), characterize protein-small molecule and protein-protein interactions, and uncover mechanistic insights of our drug discovery targets and lead molecules. You will provide expert interpretation of biophysical results and use data analysis and visualization tools to integrate data with the broader set of data generated at Treeline to drive program decisions.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Propose, design, develop, and execute biophysical assays to support hit identification, hit-to-lead, and lead optimization activities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Establish robust SPR assays for small‑molecule interaction analysis, including hit triage, affinity/kinetic characterization, and mechanism-of-action studies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Efficiently utilize a suite of biophysical techniques to advance drug discovery: primarily SPR but also including DSF, DLS, and others through in-house and CRO capabilities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Employ biophysical methods to mechanistically deconvolute the molecular mechanism of action of small molecule hits.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Effectively analyze, interpret, and communicate biophysical data as a subject matter expert and biophysics representative on project teams.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;In collaboration with chemistry, biology, lead discovery, and medicine design, characterize and establish SAR to rapidly drive the hit-to-lead process.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Propose and evaluate new approaches and technologies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide scientific leadership, mentorship, and cross-functional partnership within a dynamic matrixed environment.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Required Qualifications\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;PhD in Biophysics, Biochemistry, Chemistry, Chemical Biology or related discipline with 2-3 years of relevant postdoctoral training.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;4+ years of biotech/pharma experience with a demonstrated impact in hit identification, hit-to-lead, and lead optimization for small-molecule programs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Expertise in quantitative biophysical assay development, especially SPR for small‑molecule drug discovery. Hands-on experience characterizing protein–ligand interactions, including affinity, kinetics, stoichiometry, and mechanism.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong theoretical and practical knowledge of an array of biophysical methods with proven hands-on expertise applying biophysics for interaction analysis. Expertise with MST/SS, DSF, MS, or NMR are a plus.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated ability to troubleshoot complex assays, work with challenging proteins, and deliver high‑quality, reproducible data.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent communication, data visualization, and interpersonal skills, with a track record of effective collaboration on multidisciplinary teams.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Preferred Qualifications\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Ability to lead in a matrix environment, and for example, act as point of contact on project teams.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with fragment-based lead discovery, covalent lead discovery, and DEL are a plus.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong hands-on biochemistry experience or expertise in enzymology.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Working knowledge of adjacent disciplines (biochemistry, structural biology, protein purification, biology, chemistry).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in working with challenging proteins.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience working with CROs.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;This position is classified as exempt. The anticipated annual base salary range for candidates who will work in San Diego is $151,694 to $174,363. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, education, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;\u0026amp;nbsp;\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Recruitment fraud statement\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;We do not conduct interviews through RingCentral, Skype or Telegram.\u0026amp;nbsp;\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;You can find more information about job scams at consumer.ftc.gov/articles/job-scams.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;To report job scams, head to ReportFraud.ftc.gov.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;h2\u0026gt;Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)\u0026lt;/h2\u0026gt;\n\u0026lt;p\u0026gt;The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4068552004,"name":"Lead Discovery ","child_ids":[],"parent_id":4007732004}],"offices":[{"id":4004153004,"name":"San Diego, CA","location":"San Diego, California, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/treelinebiosciences/jobs/5830293004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5065074004,"location":{"name":"San Diego, California, United States"},"metadata":null,"id":5830293004,"updated_at":"2026-03-17T10:51:49-04:00","requisition_id":"2026-07","title":"Senior Scientist / Principal Scientist – Process Chemistry ","company_name":"Treeline Biosciences","first_published":"2026-03-17T10:51:49-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;Treeline Biosciences, a clinical-stage biotechnology company advancing precision medicines, is seeking an experienced\u0026amp;nbsp;small molecule process chemist\u0026amp;nbsp;to drive the development, scale-up, and\u0026amp;nbsp;commercial\u0026amp;nbsp;readiness of our\u0026amp;nbsp;small\u0026amp;nbsp;molecule, clinical-stage\u0026amp;nbsp;portfolio. This role\u0026amp;nbsp;centers around close collaboration with the medicinal chemistry team within the discovery portfolio. Additionally, the role is critical to\u0026amp;nbsp;ensuring\u0026amp;nbsp;clinical\u0026amp;nbsp;supply and commercial readiness for\u0026amp;nbsp;identified\u0026amp;nbsp;programs and ensuring that drug substance\u0026amp;nbsp;manufacturing\u0026amp;nbsp;processes\u0026amp;nbsp;meet quality, regulatory,\u0026amp;nbsp;safety,\u0026amp;nbsp;scalability, and scalability\u0026amp;nbsp;expectations.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;About the Position\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Senior Scientist / Principal Scientist – Process Chemistry (Discovery Process Research)\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Overview\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are seeking an experienced synthetic chemist to join our Process Chemistry (Discovery Process Research) team supporting drug discovery programs. This role focuses on route invention, reaction development, and scalable synthesis of key intermediates and drug candidates.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The scientist will lead from the bench within our project-based research and development organization, designing and executing synthetic strategies that enable discovery programs. The successful candidate will collaborate with cross-functional teams, including Medicinal Chemistry, DMPK, Toxicology, Drug Product, and Analytical Sciences to develop practical routes that support SAR exploration and deliver material for biological and early toxicology studies. The role emphasizes modern synthetic methodologies, efficient route design, and early scalability assessment.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Scientific Impact\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Enable drug discovery through innovative synthetic strategy. Develop creative and efficient routes that accelerate SAR exploration, enable rapid evaluation of new chemical matter, and deliver material for early toxicology studies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Solve complex synthetic challenges. Apply modern synthetic methodologies to access structurally complex molecules and support emerging therapeutic modalities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Translate discovery chemistry into scalable processes. Design practical routes that support both rapid compound synthesis and early-stage scale-up.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Advance cross-disciplinary drug discovery. Partner closely with discovery scientists to translate synthetic innovation into therapeutic progress.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Collaborate with medicinal chemistry partners to support candidate\u0026amp;nbsp;selection\u0026amp;nbsp;and developability assessments.\u0026amp;nbsp;\u0026amp;nbsp;Advise and\u0026amp;nbsp;assist\u0026amp;nbsp;with sourcing scaffolds and intermediates as\u0026amp;nbsp;appropriate.\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Design and execute route scouting and synthetic strategies for drug candidates and key intermediates.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Design and optimize chemical transformations and scalable synthetic routes to enable efficient and robust processes for discovery and early development programs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Enable rapid compound synthesis and methodologies to support SAR campaigns and discovery timelines.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Apply modern synthetic technologies to address complex synthetic challenges.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support multi-gram to kilogram-scale synthesis for biological and toxicology studies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Manage external partners and cultivate strong, collaborative relationships to support program objectives.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Contribute to early CMC understanding, including impurity identification and process considerations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Communicate results through technical reports, documentation, and presentations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;May be involved with preparations for the first GMP synthesis of a clincial candidate for Phase 1 trials.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to travel up to 10% to support program needs, including on-site support at manufacturing plants and partner collaboration.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Ph.D. in Organic Chemistry or related discipline with 3–8+ years of relevant industry or postdoctoral experience; M.S. with 6–10+ years of industry experience also considered.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong expertise in synthetic organic chemistry, reaction development, and route design.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with complex molecule synthesis and route optimization.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Familiarity with scale-up considerations and impurity control in chemical processes.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to work effectively within cross-functional discovery teams.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience working with and managing external\u0026amp;nbsp;CDMO\u0026amp;nbsp;partners.\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong written and verbal communication skills.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong project leadership skills with the ability to manage complex timelines, multiple stakeholders, and evolving program priorities.\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong\u0026amp;nbsp;communication\u0026amp;nbsp;and collaboration skills with a proven ability to work cross-functionally in a fast-paced, science-driven environment.\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;High level\u0026amp;nbsp;of personal integrity, commitment to excellence and to our patients\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Desired Experience\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Experience with modern synthetic methodologies and technologies (e.g., catalysis, flow chemistry, photochemistry, high-throughput experimentation, as well as other techniques).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience enabling synthesis of structurally complex drug candidates or emerging modalities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated creative problem solving in synthetic chemistry.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;This position is classified as exempt. The anticipated annual base salary range for candidates who will work in San Diego is $166,380 to $189,533. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;\u0026amp;nbsp;\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Recruitment fraud statement\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;We do not conduct interviews through RingCentral, Skype or Telegram.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;You can find more information about job scams at consumer.ftc.gov/articles/job-scams.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;To report job scams, head to ReportFraud.ftc.gov.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;h2\u0026gt;Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)\u0026lt;/h2\u0026gt;\n\u0026lt;p\u0026gt;The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4008714004,"name":"CMC","child_ids":[],"parent_id":4007732004}],"offices":[{"id":4004153004,"name":"San Diego, CA","location":"San Diego, California, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/treelinebiosciences/jobs/6008159004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5159650004,"location":{"name":"Watertown, Massachusetts, United States"},"metadata":null,"id":6008159004,"updated_at":"2026-06-01T13:32:54-04:00","requisition_id":"2026-15","title":"Vice President, Head of Quality Assurance","company_name":"Treeline Biosciences","first_published":"2026-05-29T10:08:39-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h2\u0026gt;About the Role\u0026lt;/h2\u0026gt;\n\u0026lt;p\u0026gt;The Head of Quality Assurance is responsible for providing strategic and operational quality assurance oversight for manufacturing, clinical operations, pharmacovigilance, and external partner activities across all phases of drug development, product launch and commercialization. This individual will lead the continued development, implementation, and maintenance of scalable, phase-appropriate Quality systems and governance frameworks to support clinical development, inspection readiness, manufacturing scale-up, commercialization activities, and commercial product lifecycle management. The Head of Quality will work cross-functionally with the CMC, Regulatory, Clinical Operations, and Supply Chain functions as well as external CMO, CRO, CDMO, and PV partners to ensure compliance with applicable global regulations and to maintain a strong culture of quality, integrity, patient safety, and data integrity.\u0026lt;/p\u0026gt;\n\u0026lt;h2\u0026gt;Responsibilities\u0026lt;/h2\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Build, lead, and manage a quality assurance team capable of supporting Treeline’s growing global clinical and manufacturing activities throughout the development continuum, including commercialization and lifecycle management.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide strategic and operational oversight of Treeline’s Quality Assurance operation\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Plan, conduct, and complete reports for CMO, CRO, CDMO, PV vendor, and clinical site audits.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead external Health Authority inspections, internal audits, and inspection readiness activities across GCP, GMP, and GPV functions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Continue to develop, and maintain Treeline’s Quality Management Systems, in a phase-appropriate manner, to ensure adherence to applicable global regulatory requirements and industry standards.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Author, review, and revise SOPs, policies, and controlled quality documentation.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Define and drive a pragmatic, data-driven, phase-appropriate Quality strategy aligned with company objectives and development milestones.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Establish governance frameworks, escalation pathways, and quality metrics to enable proactive risk management and informed decision-making.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide Quality oversight of external manufacturing, laboratory, packaging, labeling, and distribution partners\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversee batch record review (Executed and Master) for all phases of manufacturing, including drug substance, drug product, packaging, labeling, and associated intermediates.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Review and approve analytical documentation, including analytical methods, validation protocols and reports, specifications, stability protocols, reports, and expiry extensions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Review and approve clinical product labels.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide Quality input into CMC activities, validation strategies, manufacturing scale-up, and commercial readiness initiatives.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Responsible for final release or other disposition of clinical trial material, including country-specific release requirements and collaboration with Qualified Persons (QPs).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ensure effective oversight and timely resolution of deviations, investigations, CAPAs, change controls, and product complaints, seeking input from relevant departments to ensure fully informed evaluations of on Quality impact are made.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Review and approve quality aspects of IMPD/IND CMC sections\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ensure Quality approaches appropriately support execution of clinical trials, including oversight of CROs and GCP compliance activities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversee pharmacovigilance quality activities and vendor oversight to ensure compliance, data integrity, and effective safety surveillance.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Drive consistency in quality processes, risk management approaches, and data integrity standards across the organization.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Keep current with global health authority laws and regulations; identify gaps and implement process improvements resulting from new or revised regulations or guidance.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Participate in project teams and sub-teams as needed.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h2\u0026gt;Required Qualifications\u0026lt;/h2\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;BA/BS in Science, Engineering, or related discipline required; advanced degree (MS, PhD, PharmD, or equivalent) preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Minimum of 10+ years of Quality Assurance experience in an FDA-regulated Biotech or Pharmaceutical environment with increasing levels of responsibility.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Minimum of 5 years of hands-on experience in one or more of the following partner technical disciplines before transferring into a QA role: Chemical Development/Manufacturing, Drug Product Development/Manufacturing, Analytical Development, Clinical Trial Management.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated success in building and leading a quality organization capable of supporting a clinical/early commercial small pharmaceutical company\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated success in supporting programs from clinical development through commercial readiness and lifecycle management.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Mastery of global GxP requirements, including cGMPs (FDA/ICH), GCP, GCLP, GPV, and applicable international regulations and guidelines.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Expertise in batch review and release for clinical phase products.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Expertise authoring and reviewing SOPs, deviations, CAPAs, investigations, and change controls.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Expertise performing and managing Quality audits and regulatory inspections.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated understanding of issue management, risk management, and CAPA effectiveness in clinical and manufacturing environments.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Expertise overseeing quality aspects of global vendor networks, including CROs, CMOs, CDMOs, and pharmacovigilance vendors.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong collaboration skills and sufficient technical acumen to enable effective enable \u0026amp;nbsp;\u0026amp;nbsp;cross-functional partnering \u0026amp;nbsp;with Clinical Operations, Technical Operations, Regulatory, and other key stakeholders.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent written and verbal communication skills with strong executive presence and influencing capabilities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to manage competing priorities and timelines in a fast-paced, evolving environment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong problem-solving skills and ability to implement scalable Quality Systems improvements.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated commitment to quality, compliance, patient safety, and data integrity.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Working knowledge of oncology drug development preferred.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown, MA is $285,000 - $350,000. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the job, education, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;\u0026amp;nbsp;\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Recruitment fraud statement\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;We do not conduct interviews through RingCentral, Skype or Telegram.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;You can find more information about job scams at consumer.ftc.gov/articles/job-scams.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;To report job scams, head to ReportFraud.ftc.gov.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;h2\u0026gt;Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)\u0026lt;/h2\u0026gt;\n\u0026lt;p\u0026gt;The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4071382004,"name":"Quality ","child_ids":[],"parent_id":4007732004}],"offices":[{"id":4004152004,"name":"Watertown, MA","location":"Watertown, Massachusetts, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/treelinebiosciences/jobs/5984734004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5148639004,"location":{"name":"Watertown, Massachusetts, United States"},"metadata":null,"id":5984734004,"updated_at":"2026-05-28T13:29:36-04:00","requisition_id":"2026-11","title":"VP, Clinical Operations","company_name":"Treeline Biosciences","first_published":"2026-04-29T16:37:13-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;About the Role\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are seeking a highly motivated, proactive, strategic, and solution-focused Head of Clinical\u0026amp;nbsp;Operations. This hands-on position will lead and support all aspects of clinical trial operations\u0026amp;nbsp;including planning, implementation, execution, and management of clinical studies by overseeing\u0026amp;nbsp;day-to-day operations, including direct management of outside Clinical Research Organizations\u0026amp;nbsp;(CROs) for several clinical stage oncology assets. In this role, the Clinical Operations leader will\u0026amp;nbsp;manage multiple priorities in a fast-paced environment and enact quick problem solving to ensure\u0026amp;nbsp;the successful conduct of clinical trials and the timely delivery of high-quality data. This role will\u0026amp;nbsp;oversee early and late phase trials with an emphasis on proactivity and creative solutions to\u0026amp;nbsp;overcome regulatory and operational hurdles. The successful candidate will have experience, and interest in, working in a small, dynamic environment with broad responsibilities.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Develop and lead a team of clinical operations professionals to ensure high-quality\u0026amp;nbsp;execution of early and late phase clinical trials and the professional development of team\u0026amp;nbsp;members.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Serve as subject matter expert in clinical operations, providing guidance and expertise to\u0026amp;nbsp;cross-functional teams, including clinical development, regulatory affairs, and data\u0026amp;nbsp;management.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide operational expertise and strategic input to Clinical Development Plans and support\u0026amp;nbsp;the overall clinical strategy for clinical programs.\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proactively communicate study plans, progress, risks and mitigations with senior leaders.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop, implement, and modify when needed a successful resource and outsourcing\u0026amp;nbsp;model to meet the evolving demands of an expanding clinical portfolio.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Manage study site selection, qualification, initiation, and monitoring activities to ensure that\u0026amp;nbsp;clinical trials are conducted according to the study protocol and in compliance with\u0026amp;nbsp;regulatory requirements.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Evaluate and negotiate budgets, oversee selection and provide oversight and management\u0026amp;nbsp;of CROs, consultants and vendors to ensure the effective and timely execution of clinical\u0026amp;nbsp;trials, with high quality (including inspection ready) and within agreed budget.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Monitor progress of clinical activity and report on the progress of clinical trials including\u0026amp;nbsp;budget, timelines, enrollment, and data collection / review.\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Participate in the creation, review, and finalization of clinical study-related documents such\u0026amp;nbsp;as protocols, protocol amendments, clinical study reports (CSRs), regulatory submissions\u0026amp;nbsp;and other publications as required.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Coordinate the delivery of clinical trial supplies in collaboration with CRO and other\u0026amp;nbsp;company team members.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop and maintain strong relationships with clinical investigators and study site staff to\u0026amp;nbsp;ensure site performance, patient enrollment, and data quality; perform periodic visits to\u0026amp;nbsp;sites and/or vendors to assess progress and compliance.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ensure clinical trials maintain an inspection readiness state throughout the lifecycle of the\u0026amp;nbsp;trial and provide subject matter expertise for regulatory inspections.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Maintain knowledge across the clinical operations team of program specific therapeutic\u0026amp;nbsp;areas, current medical practice, and pharmaceutical regulations in order to ensure best\u0026amp;nbsp;practice across all activities and appropriate communication to study sites.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proactively implement process improvements and innovative approaches. Support the\u0026amp;nbsp;creation of clinical operations Standard Operating Procedures (SOPs), systems, and\u0026amp;nbsp;processes across the trials; ensures compliance with regulatory and other applicable\u0026amp;nbsp;standards and guidelines.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Bachelor’s degree (BA/BS) in a relevant scientific field (e.g. nursing, biology, biochemistry,\u0026amp;nbsp;or related areas); advanced degree preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;At least 15 years of experience of successfully leading studies within clinical research\u0026amp;nbsp;operations. Experience with both small and large biotechnology companies is favorable.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in Phase I-III oncology clinical studies. Global experience preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated expertise building and managing clinical operations teams.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent verbal and written skills, allowing for an open and effective dialogue throughout\u0026amp;nbsp;the company.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Highly accountable for the results and outcomes of their responsibilities and understands\u0026amp;nbsp;the impact of their efforts, results, and attitudes on others.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with agency submissions and inspections, understands adherence to SOPs,\u0026amp;nbsp;ICH/GCP, and FDA and other health authorities’ regulations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Forward thinking mindset with ability to manage multiple projects, identify and resolve\u0026amp;nbsp;issues.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong analytical, organizational, and time management skills with a track record of\u0026amp;nbsp;identifying and implementing novel solutions and problem-solving.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated agility and ability to navigate and be successful in a fast-paced, dynamic\u0026amp;nbsp;work environment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven hands-on leadership and communication skills (written and verbal).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Team player who collaborates effectively with internal stakeholders as well as external\u0026amp;nbsp;contract organizations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Be a champion of a highly collaborative, transparent, data driven, “make it happen” culture.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown, MA is $319,333 - $375,665. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the job, education, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;\u0026amp;nbsp;\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;Recruitment fraud statement\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;We do not conduct interviews through Skype or Telegram. \u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;You can find more information about job scams at consumer.ftc.gov/articles/job-scams.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;em\u0026gt;To report job scams, head to ReportFraud.ftc.gov.\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;h2\u0026gt;Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)\u0026lt;/h2\u0026gt;\n\u0026lt;p\u0026gt;The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4008713004,"name":"Clinical","child_ids":[],"parent_id":4007732004}],"offices":[{"id":4004152004,"name":"Watertown, MA","location":"Watertown, Massachusetts, United States","child_ids":[],"parent_id":null}]}],"meta":{"total":8}}