{"jobs":[{"absolute_url":"https://job-boards.greenhouse.io/spyretherapeutics/jobs/5231284008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"education":"education_required","internal_job_id":4480090008,"location":{"name":"US- Remote"},"metadata":null,"id":5231284008,"updated_at":"2026-05-27T11:41:06-04:00","requisition_id":"Tech-27-3","title":"Associate Director, Analytical Sciences and Attribute Characterization","company_name":"Spyre Therapeutics","first_published":"2026-05-27T11:41:06-04:00","language":"en","application_deadline":null,"content":"\u0026lt;div class=\u0026quot;content-intro\u0026quot;\u0026gt;\u0026lt;p\u0026gt;Spyre Therapeutics is a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients. Spyre\u0026#39;s pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Role Summary:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Associate Director, Analytical Sciences and Attribute Characterization, oversees structural and functional characterization and comparability studies across Spyre’s clinical and late-stage mAb and mAb-mAb combination programs. This role is a key leader within the Analytical Development and Quality Control (ADQC) organization and reports directly to the Vice President.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The position provides both strategic and operational leadership for analytical characterization and comparability, in close collaboration with internal process, analytical, and regulatory teams, as well as global CDMO partners. The Associate Director defines phase-appropriate characterization and comparability strategies that support formulation, process, and analytical development, quality control, and regulatory submissions, aligned with regulatory expectations and industry best practices. This role drives proactive planning to ensure efficient advancement of drug candidates through clinical development stages.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Provide strategic and technical leadership for multidimensional biologics characterization to support product understanding and comparability in a phase-appropriate manner, enabling regulatory submissions for clinical development through BLA \u0026amp;amp; MAA, primarily executed through global CDMO partners.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Serve as subject matter expert (SME) in mAb and mAb-mAb combination product molecular characterization and comparability, applying a fit-for-purpose suite of biochemical, biophysical, physicochemical, and functional assays (e.g., advanced mass spectrometry, capillary and chromatographic methods, deterministic biophysical and particle analyses, Fc function assays including SPR, cell-based assays, and surfactant analysis).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Contribute to analytical control strategies and regulatory content development, ensuring scientific rigor, comprehensive product understanding, and assessment of process impacts on product quality attributes across DS, DP, placebo, and device manufacturing.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead comparability and characterization activities at CDMOs, including review and approval of protocols, reports, and data packages, and verification of analytical results to support regulatory submissions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ensure analytical activities, both internal and external, meet scientific, regulatory (FDA, EMA, ICH), and industry standards.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop characterization strategies in collaboration with analytical SMEs, ensuring alignment and complementarity with QC methods for release, stability, and in-process controls.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partner with process (DS, DP, device) and regulatory teams to establish product-appropriate characterization and comparability plans.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support ADQC activities, including method development, investigations, and review of QC release and stability data, as needed.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Establish best practices and protocols for structure–function relationships, post-translational modification (PTM) analysis, biophysical characterization, and critical quality attribute (CQA) assessment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Other duties as assigned.\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Ideal Candidate:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Advanced degree in Mass spectrometry, Biophysical chemistry, Analytical Chemistry, Pharmaceutical Sciences, Biochemistry or a related discipline, with 8+ years of biopharma industry experience in biologics analytical, formulation or process development.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated experience and success supporting regulatory submissions (IND, CTA, BLA), with strong expertise in phase-appropriate characterization and comparability studies and associated analytical methods.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven leadership and effective communication skills, with the ability to manage biologics program deliverables in a fast-paced environment; experience with mAb combination products is preferred, and device testing is an advantage.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience leveraging artificial intelligence (AI) and machine learning (ML) to enhance analytical efficiency, automate attribute trending, and support knowledge generation and decision-making.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;What We Offer:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare \u0026amp;amp; retirement benefits.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Unlimited PTO\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Two, one-week company-wide shutdowns each\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Commitment to provide professional development opportunities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Remote working environment with frequent in-person meetings to address complex problems and build relationships.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The expected salary range offer for this role is $175,000 to $190,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;p\u0026gt;As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Please also be aware that all job postings will be listed on our website at spyre.com/careers/.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4000558008,"name":"TechOps","child_ids":[],"parent_id":4000569008}],"offices":[{"id":4000238008,"name":"U.S. Remote","location":"United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/spyretherapeutics/jobs/5234283008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"education":"education_required","internal_job_id":4481500008,"location":{"name":"US- Remote"},"metadata":null,"id":5234283008,"updated_at":"2026-05-28T19:54:47-04:00","requisition_id":"ClinOps-26-3","title":"Clinical Trial Manager, Clinical Operations","company_name":"Spyre Therapeutics","first_published":"2026-05-28T19:54:47-04:00","language":"en","application_deadline":null,"content":"\u0026lt;div class=\u0026quot;content-intro\u0026quot;\u0026gt;\u0026lt;p\u0026gt;Spyre Therapeutics is a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients. Spyre\u0026#39;s pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Role Summary:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Clinical Trial Manager (CTM) is a pivotal role responsible for the management of Clinical Trials from vendor selection through Clinical Study Report (CSR) completion. The CTM will organize and supervise clinical trials, ensuring they meet all company and regulatory requirements. The CTM will collaborate closely with internal R\u0026amp;amp;D team members in addition to external CRO partners to drive successful trial execution to advance the development of our cutting-edge antibody conjugate portfolio ensuring efficacy, safety, and regulatory success.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Responsible for the management of Clinical Trials from vendor selection through Clinical Study Report (CSR) completion.\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ensure clinical trial activities are completed on time, within budget and in a highly dynamic and complex environment in accordance with appropriate quality standards including ICH/GCP requirements.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Create and implement study-specific clinical monitoring tools and documents,\u0026amp;nbsp;including informed consent development and EU CTR.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead the identification, evaluation, selection, and oversight of clinical trial sites.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Author and implement operational plans to ensure efficient study enrollment and high-quality monitoring activities at clinical sites.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Review/approve vendor and site invoices and track study budget to forecast, working closely with finance and clinical business operations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Responsible for implementation and oversight of Trial Master File for inspection readiness.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Drive overall process and provide support to cross-functional teams in the development of study documents including study protocols, consent forms and budget templates.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Serve as lead in the creation of project plans, logs, templates, newsletters, and other documents.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Review and approve site specific documents (such as informed consent forms, site budgets, monitoring reports) along with other relevant project team members.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide study updates and reports, inclusive of study risks and issues.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead internal and external meetings for assigned clinical trial(s), including Investigator Meetings, conferences, events and study management meetings.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Responsible for ongoing study data reviews and data cleaning activities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide oversight of CTA and CRA activities such as site identification, qualification, selection, initiation, data quality, sample tracking, interim monitoring and close out activities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Manage trial-level quality risk management.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversee study supplies management.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support the development and complete the delivery of study training to investigators, site staff and internal staff on study processes.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Participate in the preparation and follow up of internal process audits, vendor, and study site quality audits as well as regulatory inspections.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Other duties as assigned.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Ideal Candidate:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;B.A./B.S. in life sciences or equivalent\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;A minimum of 5 years of clinical research experience within the pharmaceutical or biotechnology industry, with at least 2+ years managing early phase clinical trials; managing global clinical trials a plus\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Inflammation and/or Immunology experience is strongly preferred\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong working knowledge of clinical operations and experience with clinical study conduct from start-up through close-out\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Informed consent development and EU CTR experience\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to lead cross functional study teams in a matrix organization\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Working knowledge of FDA/ICH guidelines and industry/technology standard practices including Good Clinical Practices; trial initiation and management practices and procedures\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent communication and interpersonal skills, with the ability to lead and motivate teams and collaborate effectively across functions.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;What We Offer:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare \u0026amp;amp; retirement benefits.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Unlimited PTO\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Two, one-week company-wide shutdowns each\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Commitment to provide professional development opportunities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Remote working environment with frequent in-person meetings to address complex problems and build relationships.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The expected salary range offer for this role is $135,000 to $155,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;p\u0026gt;As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Please also be aware that all job postings will be listed on our website at spyre.com/careers/.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4005315008,"name":"Clinical Operations","child_ids":[],"parent_id":4000569008}],"offices":[{"id":4000238008,"name":"U.S. Remote","location":"United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/spyretherapeutics/jobs/5171515008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"education":"education_required","internal_job_id":4452103008,"location":{"name":"US- Remote"},"metadata":null,"id":5171515008,"updated_at":"2026-04-08T19:08:32-04:00","requisition_id":"Biostat-26-2","title":"Senior Director, Biostatistics","company_name":"Spyre Therapeutics","first_published":"2026-03-31T17:52:42-04:00","language":"en","application_deadline":null,"content":"\u0026lt;div class=\u0026quot;content-intro\u0026quot;\u0026gt;\u0026lt;p\u0026gt;Spyre Therapeutics is a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients. Spyre\u0026#39;s pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Role Summary:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Sr. Director of Biostatistics will provide leadership and strategic input for clinical development programs assigned. The selected individual will be responsible for statistical activities supporting clinical trials, including contributing to trial designs, authoring statistical sections of protocols, preparing statistical analysis plans, and reviewing and interpreting the analysis of clinical trial data. This is a hands-on role where you will interact with internal and external cross-functional study teams, support interactions with Health Authorities globally, conduct ad-hoc analyses, and manage biometrics vendors in preparing analysis files, performing statistical analyses, and delivering analysis results and data files.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Lead the biometrics team including statistician, data manager, and statistical programmer at a program level.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide statistical input to strategic planning, study design, protocol development, sample size calculation, CRF, Results Interpretation, clinical study report, and address questions from regulatory agencies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Promote research of advanced and innovative statistical methods to increase probability of success of clinical studies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Author and develop SAPs, and work with extended team or vendor in developing specification for derived variables, templates of statistical tables, figures, and listings.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide guidance to study team on all aspects of statistical activities; collaborate closely with data manager to ensure high-quality data.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Participate in cross-functional study-related activities; Work collaboratively with Clinical Development, Clinical Operations, Clinical Data Managers, Pharmacovigilance ＆ Epidemiology, Regulatory, Project Management, Translational Medicine, and other staff and vendors to meet project deliverables and timelines.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;CRO / Vendor Oversight: Establish procedures through regular interaction, setting expectations on deliverables and timelines. Ensure deliverables are accurate and delivered according to timelines.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Global Health Authority Interaction: Contribute to documents submitted to Health Authorities globally by providing input for the interaction or by writing the interaction document. May participate in meetings or teleconferences with Health Authorities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Coordinate with internal and external team members to prepare the statistical analyses for IB, DSUR updates, periodic safety updates, and other ad hoc analyses.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Build and develop efficient biostatistical processes and standards.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Other duties as assigned.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Ideal Candidate:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;PhD Degree in Biostatistics, Statistics, or a related field with at least 10-12 years of experience in biostatistics within the pharmaceutical, biotech, or CRO industry.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong knowledge of statistical methodologies and their application in clinical trials and health research. Working knowledge of Bayesian methodology and causal inference is preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with regulatory submissions and interactions with regulatory agencies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proficiency in statistical software (e.g., SAS, R) and data management systems.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with CDSIC including SDTM, ADaM, CDASH.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Successful track record of working independently in a matrixed organization and providing solutions to emerging problems.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent communication and interpersonal skills, along with organizational skills.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to work collaboratively in a multidisciplinary team environment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in people management is preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;What We Offer:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare \u0026amp;amp; retirement benefits.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Unlimited PTO\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Two, one-week company-wide shutdowns each\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Commitment to provide professional development opportunities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Remote working environment with frequent in-person meetings to address complex problems and build relationships.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The expected salary range offer for this role is $275,000 to $290,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;p\u0026gt;As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Please also be aware that all job postings will be listed on our website at spyre.com/careers/.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4025404008,"name":"Biometrics","child_ids":[],"parent_id":4000569008}],"offices":[{"id":4000238008,"name":"U.S. Remote","location":"United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/spyretherapeutics/jobs/5209031008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"education":"education_required","internal_job_id":4469148008,"location":{"name":"US- Remote"},"metadata":null,"id":5209031008,"updated_at":"2026-05-05T12:19:18-04:00","requisition_id":"Reg-26-3","title":"Senior Manager, Regulatory Affairs CMC","company_name":"Spyre Therapeutics","first_published":"2026-05-05T12:12:37-04:00","language":"en","application_deadline":null,"content":"\u0026lt;div class=\u0026quot;content-intro\u0026quot;\u0026gt;\u0026lt;p\u0026gt;Spyre Therapeutics is a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients. Spyre\u0026#39;s pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Role Summary:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;As the Senior Manager, Regulatory Affairs CMC), you will operate as the Regulatory CMC lead for multiple programs, owning strategy and execution from early development through clinical milestones. This is a high-impact, high-ownership role for someone who thrives in a fast-moving biotech environment.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;You will be expected to lead from the front—writing, project-managing, problem-solving, and delivering—not just coordinating. This role requires technical CMC expertise, strong communication skills, and the ability to manage multiple priorities.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Act as the Reg CMC lead for assigned programs, driving strategy, execution, and timelines.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Personally author sections of Module 2 and 3 (QOS, drug substance, drug product, comparability, stability, etc.).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Own CMC regulatory deliverables end-to-end with minimal oversight.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead and deliver global submissions (INDs, IMPDs, CTAs, amendments, annual reports) with a focus on timeliness, quality, and completeness.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Identify risks early and lead teams to resolution to keep programs on track.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Translate complex technical data into clear and concise narratives.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead preparation of CMC-related responses to HA questions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Act as a connector and leader in discussions, not a passive participant.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Manage multiple programs, while prioritizing effectively.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Other duties as assigned.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Ideal Candidate:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Bachelor’s degree with a minimum of 5+ years of experience in CMC regulatory affairs, supporting clinical-stage biologics programs (or equivalent combination of education and experience).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience as the primary CMC regulatory lead for clinical stage programs (EU CTR and ROW experience is a plus).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Hands-on authoring experience for IND and IMPD submissions and amendments, including direct responsibility for authoring CMC sections.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Exceptional technical writing skills, with the ability to clearly communicate complex technical information in regulatory documents and health authority responses.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven experience preparing responses to CMC health authority questions during clinical development.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong understanding of global CMC regulatory requirements and guidelines including FDA, EMA, and ICH.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong attention to detail, organizational skills, and the ability to manage multiple concurrent submissions and timelines in a fast-paced environment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent written and verbal communication skills, with the ability to collaborate effectively across technical and cross-functional teams.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proficiency with regulatory submission and document management systems (e.g., Veeva RIM, eCTD publishing platforms, document repositories).\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;What We Offer:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare \u0026amp;amp; retirement benefits.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Unlimited PTO\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Two, one-week company-wide shutdowns each\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Commitment to provide professional development opportunities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Remote working environment with frequent in-person meetings to address complex problems and build relationships.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The expected salary range offer for this role is $150,000 to $176,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;p\u0026gt;As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Please also be aware that all job postings will be listed on our website at spyre.com/careers/.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4000567008,"name":"Regulatory","child_ids":[],"parent_id":4000569008}],"offices":[{"id":4000238008,"name":"U.S. Remote","location":"United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/spyretherapeutics/jobs/5233333008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"education":"education_required","internal_job_id":4481060008,"location":{"name":"US- Remote"},"metadata":null,"id":5233333008,"updated_at":"2026-05-29T14:06:17-04:00","requisition_id":"FIN-26-2","title":"Senior Payroll and Accounting Specialist","company_name":"Spyre Therapeutics","first_published":"2026-05-29T13:01:08-04:00","language":"en","application_deadline":null,"content":"\u0026lt;div class=\u0026quot;content-intro\u0026quot;\u0026gt;\u0026lt;p\u0026gt;Spyre Therapeutics is a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients. Spyre\u0026#39;s pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Role Summary:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Spyre Therapeutics, Inc., is actively recruiting an experienced Senior Payroll and Accounting Specialist to join our accounting team. The Payroll and Accounting Specialist will be a key member of the accounting department, responsible for the integrity of the Company’s compensation cycles and equity administration. Responsibilities include full-cycle general ledger accounting, end-to-end payroll administration, equity platform management, and ensuring strict adherence to Sarbanes-Oxley (SOX) requirements. This position will support our increased operational needs as our company grows, playing a vital role in reconciling stock-based compensation, managing payroll tax compliance, and other accounting tasks as needed. Attention to detail and the ability to maintain precise account balances and general ledger accuracy are all essential skills for this position. The ideal candidate should be comfortable working collaboratively with cross-functional teams and independently and excel when faced with the unique challenges of a scaling organization.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Manage the full-cycle payroll process, including data entry, tax withholdings, and benefits deductions, etc.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ensure all payroll activities align with federal, state, and local tax regulations, including the proper handling of withholdings and filings.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Perform regular audits of payroll data and reconcile payroll bank accounts to ensure accuracy and identify discrepancies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Coordinate with HR to ensure accurate deductions for health insurance, retirement plans (401k), and other voluntary benefits.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Act as the primary point of contact for staff regarding pay-related inquiries, resolving issues related to paychecks or tax forms with high confidentiality.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Identify opportunities to streamline payroll workflows and improve the efficiency of the payroll software or HRIS.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Prepare and post monthly journal entries for payroll accruals, benefits, taxes, and other standard corporate expenses.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Maintain T\u0026amp;amp;E system including syncing to the Company’s ERP and reviewing expense transactions for compliance with Company policies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Assist in the preparation of monthly and quarterly financial statements by ensuring all payroll-related expenses are accurately categorized.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Maintain and document internal controls (such as SOX compliance procedures) to ensure the integrity of financial reporting and prevent fraud.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Facilitate the issuance of new equity awards (RSUs, Stock Options, or ESPP) by ensuring all grant agreements are properly executed and recorded in the equity platform.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Monitor vesting schedules and process stock option exercises, ensuring the accurate flow of data between the equity platform and payroll for tax withholding.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Other duties as assigned.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Ideal Candidate:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Bachelor’s degree in Accounting or related field\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;5+ years of payroll and accounting experience\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience managing payroll and tax withholdings across multiple states. Experience with international locations is a plus.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proficiency in payroll/HRIS and equity management platforms (i.e. Rippling, Fidelity, E*TRADE)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Solid understanding of the lifecycle of various equity vehicles, including RSUs, NSOs, ISOs, and ESPPs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;A proven track record of handling highly sensitive executive compensation and employee financial data with total discretion.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent organizational, analytical, prioritization and problem-solving skills in an environment of high volume of projects; detail-oriented\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Possesses a professional demeanor, discretion and judgment\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to work effectively and establish and promote positive relationships\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Self-starter who possesses initiative and ability to work alone while capable of driving business results without significant supervision\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must have schedule flexibility to meet the demands of monthly and quarterly close\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent verbal and written communication skills\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to work effectively with all employee levels and external contacts\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;What We Offer:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare \u0026amp;amp; retirement benefits.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Unlimited PTO\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Two, one-week company-wide shutdowns each\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Commitment to provide professional development opportunities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Remote working environment with frequent in-person meetings to address complex problems and build relationships.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The expected salary range offer for this role is $110,000 to $130,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;p\u0026gt;As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Please also be aware that all job postings will be listed on our website at spyre.com/careers/.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4000561008,"name":"Finance","child_ids":[],"parent_id":4000568008}],"offices":[{"id":4000238008,"name":"U.S. Remote","location":"United States","child_ids":[],"parent_id":null}]}],"meta":{"total":5}}