{"jobs":[{"absolute_url":"https://job-boards.greenhouse.io/septerna/jobs/5176011008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"education":"education_required","internal_job_id":4454187008,"location":{"name":"South San Francisco, California, United States"},"metadata":null,"id":5176011008,"updated_at":"2026-04-16T13:22:41-04:00","requisition_id":"105","title":"Director, Clinical Operations","company_name":"Septerna","first_published":"2026-04-16T13:21:36-04:00","language":"en","application_deadline":null,"content":"\u0026lt;div class=\u0026quot;content-intro\u0026quot;\u0026gt;\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;For more information see: \u0026lt;a href=\u0026quot;http://www.septerna.com\u0026quot;\u0026gt;www.septerna.com\u0026lt;/a\u0026gt;.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;THE ROLE\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Director, Clinical Operations will lead the strategic planning, execution, and continuous improvement of Septerna’s clinical programs across multiple therapeutic areas. This role is pivotal in a dynamic, fast-growing biotech environment and will ensure our clinical trials are delivered with excellence—on time, within budget, and in compliance with regulatory and quality standards.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;This is an exciting opportunity with significant room for growth and visibility across the organization. The Director will work closely with senior leadership and cross-functional teams, gaining exposure to all levels of the company while helping to shape the future of Septerna’s clinical operations. The ideal candidate combines deep operational expertise with a patient-first mindset, thrives in collaboration, and brings creativity and structure to a scaling organization.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Lead operational planning and execution of clinical programs (Phase I–III, including patient-facing , global studies) in alignment with development goals.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversee end-to-end delivery of clinical trials: define timelines, budgets, risk mitigation, resource allocation, and monitoring of results.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Select, contract, and manage CROs and external vendors; build strong vendor relationships, ensure accountability to scope, budget, milestones, and quality.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborate across functions — Clinical Development, Regulatory, Biometrics/Data, QA,\u0026amp;nbsp; — to ensure aligned execution and streamlined decision-making.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Build and mentor a growing clinical operations team; drive team development, foster a culture of learning, accountability, innovation, and high performance.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Drive operational excellence by creating and implementing fit-for-purpose processes, systems and tools that support a scaling organization — standardizing templates, SOPs, dashboards, KPIs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrate ability to quickly adopt new therapeutic areas, adapt to evolving science and growing strategic demands.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Bring creative, out-of-the-box thinking to optimize trial design, site operations, patient engagement, vendor strategies and operational efficiency.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ensure inspection readiness and adherence to ICH-GCP, SOPs and global regulatory standards; partner with QA to maintain operational integrity.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Establish and track meaningful metrics (KPIs) to manage progress, proactively manage risks, and drive continuous improvement in trial efficiency and data quality.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Advanced degree (MS, PharmD, PhD) preferred; or bachelor’s degree in life sciences/clinical research with equivalent robust experience.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Minimum 10 \u0026amp;nbsp;years’ experience in clinical operations in biotech or pharma, with leadership of multiple global clinical programs (including patient-facing studies).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated success in building and mentoring teams; experience in a growing/scaling environment is highly desirable.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven track record managing CROs/external vendors, budgets/timelines, and operational delivery in a complex setting.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Effective cross-functional collaborator; strong communicator able to navigate a matrixed, fast-moving organization.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in or ability to quickly learn new therapeutic areas (endorcrinology, immunology/inflammation, metabolic disease or similar) is strongly preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated process-orientation: able to build, refine and standardize systems, tools, SOPs, dashboards and metrics.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strategic thinker with proactive, solution-driven mindset; able to bring innovative thinking to trial operations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Results-oriented, detail conscious, and adept at managing multiple priorities under deadlines.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The anticipated salary range for candidates who will work in South San Francisco, CA is $225,000 - $250,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna\u0026#39;s compensation package also includes benefits, stock options, and annual target bonus for full-time positions.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;div style=\u0026quot;line-height: 1;\u0026quot;\u0026gt;\u0026amp;nbsp;\u0026lt;/div\u0026gt;\n\u0026lt;div style=\u0026quot;line-height: 1;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;Septerna participates in the E-Verify program.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;em\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;California Consumer Privacy Act Privacy Notice For Job Applicants.\u0026amp;nbsp; If you are a California resident, click \u0026lt;a href=\u0026quot;https://septerna.com/california-consumer-privacy-act-privacy-notice-for-job-applicants/\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;here\u0026lt;/a\u0026gt; for our CCPA Notice.\u0026lt;/span\u0026gt;\u0026lt;/em\u0026gt;\u0026lt;/div\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4020400008,"name":"3200 - Development : Clinical operations","child_ids":[],"parent_id":4020405008}],"offices":[{"id":4007635008,"name":"Septerna Headquarters","location":"South San Francisco, California, United States","child_ids":[4008667008],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/septerna/jobs/5176169008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"education":"education_required","internal_job_id":4454247008,"location":{"name":"South San Francisco, California, United States"},"metadata":null,"id":5176169008,"updated_at":"2026-04-23T09:47:16-04:00","requisition_id":"106","title":"Director/Senior Director, Regulatory Affairs","company_name":"Septerna","first_published":"2026-04-23T09:45:33-04:00","language":"en","application_deadline":null,"content":"\u0026lt;div class=\u0026quot;content-intro\u0026quot;\u0026gt;\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;For more information see: \u0026lt;a href=\u0026quot;http://www.septerna.com\u0026quot;\u0026gt;www.septerna.com\u0026lt;/a\u0026gt;.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;\u0026lt;div\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;About the Role\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Septerna is seeking an experienced and highly motivated Director/Senior Director of Regulatory Affairs to lead regulatory strategy and execution across our discovery and development programs. This individual will be responsible for developing and implementing regulatory plans and submissions to support preclinical and clinical development, IND/CTA submissions, and interactions with global health authorities. The ideal candidate will bring deep regulatory expertise, strong cross-functional leadership, and a proactive, strategic mindset suited to a fast-paced biotech environment. This position reports into the VP, Regulatory Affairs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Develop and implement regulatory strategies for clinical stage programs, ensuring alignment with business and development objectives.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Serve as the primary Regulatory Affairs representative on project teams, providing guidance on regulatory requirements and pathways.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead the preparation, review, and submission of high-quality regulatory documents, including INDs, CTAs, amendments, briefing packages, and responses to health authority inquiries.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Manage interactions with FDA and other global regulatory agencies; coordinate and prepare for regulatory meetings.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partner with CMC, Nonclinical, and Clinical teams to ensure compliance with applicable regulations and consistent messaging across submissions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Identify regulatory risks and proactively work with cross-functional teams to develop mitigation strategies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Monitor the evolving regulatory landscape and communicate implications for Septerna’s programs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support the development of internal regulatory processes, systems, and documentation to enable scalability as the organization grows.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Mentor and develop junior regulatory staff and contribute to a culture of collaboration and excellence.\u0026lt;strong\u0026gt;\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Bachelor’s degree in life sciences or a related field; advanced degree (PhD, PharmD, or MS) preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Prior experience as a Global Regulatory Lead (GRL) preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;10+ years of experience in Regulatory Affairs within the biopharmaceutical industry, including direct experience leading IND and/or CTA submissions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven track record of successful interactions with the FDA and other global regulatory agencies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong understanding of drug development processes, from discovery through clinical stages.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent project management, organizational, and verbal and written communication skills.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;High attention to detail and accuracy.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to thrive in a dynamic, fast-paced environment and work effectively across functions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Hands-on, strategic thinker with a collaborative and solution-oriented mindset.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/div\u0026gt;\n\u0026lt;div\u0026gt;The anticipated salary range for candidates who will work in South San Francisco, CA is $235,000 - $285,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna\u0026#39;s compensation package also includes benefits, stock options, and annual target bonus for full-time positions.\u0026lt;/div\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;div style=\u0026quot;line-height: 1;\u0026quot;\u0026gt;\u0026amp;nbsp;\u0026lt;/div\u0026gt;\n\u0026lt;div style=\u0026quot;line-height: 1;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;Septerna participates in the E-Verify program.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;em\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;California Consumer Privacy Act Privacy Notice For Job Applicants.\u0026amp;nbsp; If you are a California resident, click \u0026lt;a href=\u0026quot;https://septerna.com/california-consumer-privacy-act-privacy-notice-for-job-applicants/\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;here\u0026lt;/a\u0026gt; for our CCPA Notice.\u0026lt;/span\u0026gt;\u0026lt;/em\u0026gt;\u0026lt;/div\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4020401008,"name":"3300 - Development : Regulatory affairs","child_ids":[],"parent_id":4020405008}],"offices":[{"id":4007635008,"name":"Septerna Headquarters","location":"South San Francisco, California, United States","child_ids":[4008667008],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/septerna/jobs/5225259008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"education":"education_required","internal_job_id":4477147008,"location":{"name":"South San Francisco, California, United States"},"metadata":null,"id":5225259008,"updated_at":"2026-05-19T12:47:55-04:00","requisition_id":"112","title":"Senior Director, Technical Accounting","company_name":"Septerna","first_published":"2026-05-19T12:47:44-04:00","language":"en","application_deadline":null,"content":"\u0026lt;div class=\u0026quot;content-intro\u0026quot;\u0026gt;\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;For more information see: \u0026lt;a href=\u0026quot;http://www.septerna.com\u0026quot;\u0026gt;www.septerna.com\u0026lt;/a\u0026gt;.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;THE ROLE\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Septerna is seeking an experienced and highly motivated Senior Director of Technical Accounting to lead and oversee complex accounting matters and ensure compliance with U.S. GAAP across the organization. This individual will play a critical role in supporting financial reporting, evaluating technical accounting issues, and building scalable accounting policies and processes as the company grows.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The ideal candidate will bring deep technical accounting expertise, strong judgment, and the ability to operate effectively in a fast-paced biotech environment. This position will work closely with Finance, FP\u0026amp;amp;A, Legal, Investor Relations, and external auditors, and will report into the Vice President, Finance and Business Operations.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities:\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Lead the assessment and documentation of technical accounting matters, including revenue recognition, stock-based compensation, equity transactions, leases, and collaboration/licensing agreements\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Research, interpret, and implement new accounting standards and ensure ongoing compliance with U.S. GAAP and SEC reporting requirements\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Prepare technical accounting memos and position papers to support conclusions and external audit reviews\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partner with Legal and Finance to review and structure complex contracts and transactions to ensure appropriate accounting treatment\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support the preparation and review of financial statements and disclosures, including 10-Ks, 10-Qs, and other SEC filings (as applicable)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Serve as a key liaison with external auditors, driving efficient and effective audit and review processes\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Establish and maintain accounting policies, procedures, and internal controls to support a growing organization\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support M\u0026amp;amp;A, business development, and financing transactions, including due diligence and accounting integration\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Mentor team members and contribute to building a high-performing accounting function\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Bachelor’s degree in Accounting or related field; active CPA required\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;A minimum of 10+ years of progressive accounting experience, including public accounting (Big 4 or equivalent) and biotechnology, life sciences or pharmaceutical industry experience\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong expertise in U.S. GAAP, revenue recognition, clinical trial accruals, equity, and SEC reporting in public companies\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven ability to research and resolve complex accounting issues and communicate conclusions clearly\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience working cross-functionally and influencing stakeholders across Finance, Legal, and business teams\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong analytical, organizational, and problem-solving skills with high attention to detail\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to thrive in a fast-paced, dynamic environment and manage multiple priorities effectively\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborative, proactive, and solutions-oriented mindset with a focus on continuous improvement\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The anticipated salary range for candidates who will work in South San Francisco, CA is $270,000 - $290,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna\u0026#39;s compensation package also includes benefits, stock options, and annual target bonus for full-time positions.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;div style=\u0026quot;line-height: 1;\u0026quot;\u0026gt;\u0026amp;nbsp;\u0026lt;/div\u0026gt;\n\u0026lt;div style=\u0026quot;line-height: 1;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;Septerna participates in the E-Verify program.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;em\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;California Consumer Privacy Act Privacy Notice For Job Applicants.\u0026amp;nbsp; If you are a California resident, click \u0026lt;a href=\u0026quot;https://septerna.com/california-consumer-privacy-act-privacy-notice-for-job-applicants/\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;here\u0026lt;/a\u0026gt; for our CCPA Notice.\u0026lt;/span\u0026gt;\u0026lt;/em\u0026gt;\u0026lt;/div\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4009890008,"name":"9600 - G\u0026A : Finance and accounting","child_ids":[],"parent_id":4009888008}],"offices":[{"id":4007635008,"name":"Septerna Headquarters","location":"South San Francisco, California, United States","child_ids":[4008667008],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/septerna/jobs/5248949008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"education":"education_required","internal_job_id":4486647008,"location":{"name":"South San Francisco, California, United States"},"metadata":null,"id":5248949008,"updated_at":"2026-06-05T12:14:47-04:00","requisition_id":"114","title":"Senior Manager, Analytical Quality Control","company_name":"Septerna","first_published":"2026-06-05T12:14:05-04:00","language":"en","application_deadline":null,"content":"\u0026lt;div class=\u0026quot;content-intro\u0026quot;\u0026gt;\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;For more information see: \u0026lt;a href=\u0026quot;http://www.septerna.com\u0026quot;\u0026gt;www.septerna.com\u0026lt;/a\u0026gt;.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;THE ROLE\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are seeking an experienced and highly motivated Senior Manager of Analytical Quality Control to manage analytical development and quality control activities on our small molecule programs with manufacturing and testing at Contract Development and Manufacturing Organizations (CDMOs). This individual will leverage expertise in analytical data review and data trending to effectively manage stability studies, reference standards, and technical change controls.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Provide QC oversight of analytical testing and stability studies performed at CDMOs for reference materials, drug substance, drug product, placebo, and finished goods and perform in-depth reviews of raw analytical data to ensure data integrity and compliance with specifications.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Establish and maintain processes for tracking and trending of CDMO testing against release and stability schedules.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Manage reference standards and reference materials including qualification, retest date and requalification, and inventory tracking.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Author and review stability summary reports based on stability data report and including scientific justification of drug substance retest periods and drug product shelf-life in alignment with industry standards and regulatory guidelines.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support development of and maintain compliance with the quality system to ensure product quality and data integrity, including authoring and reviewing standard operating procedures, guidelines, and work instructions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Review analytical method validation protocols and reports, change controls, corrective and preventative actions, deviations, and investigations, including OOS and OOT events.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Author, review and verify data in CMC sections of regulatory documents and submissions (IMPD, IB, IND, NDA, etc.) and the supporting technical documents, while remaining current on Health Authority guidance and expectations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support the evaluation, selection, and management of CDMOs to perform reference standard management, GMP manufacture, release testing, and stability studies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborate cross functionally with teams including Analytical Development Process Chemistry, Pharmaceutical Development, Supply Chain Management, Quality, Regulatory, DMPK, Toxicology, and Clinical Pharmacology to achieve project goals.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;A BS, MS, or PhD degree in analytical chemistry or related field with a minimum of 10 years, 8 years, or 5 years, respectively, of relevant industry experience with demonstrated increasing responsibilities within analytical quality control.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated execution of QC activities supporting programs through clinical development.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated experience performing and managing analytical method development, phase appropriate method qualification/validation, and release and stability testing.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Knowledge of analytical techniques for small molecules and oral solid dose products. Must be proficient in IR, UPLC/HPLC, KF, GC, dissolution, and microbial limit tests.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven proficiency working with quality systems including SOPs, protocols and reports, release and stability data review, OOT and OOS management, Good Documentation Practices, LIMS and cGMP data traceability, Deviations, and Change Management.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience applying compendial standards and regulatory authority guidance and expectations, including ICH, FDA, MHRA, and EMA guidelines and USP-NF, Ph. Eur, BP, and JP compendia.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated experience managing and collaborating with external partners, including CDMOs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Exhibited strong organizational and critical thinking skills with an attention to detail facilitating efficient data, document, and knowledge management across CMC.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent interpersonal and communication skills (written and oral) with the ability to effectively and concisely present data to peers, management, and external groups.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Effective management of multiple priorities in a fast-paced environment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to travel domestically and internationally as needed, up to 10% of the time.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The anticipated salary range for candidates who will work in South San Francisco, CA is $175,000 - $195,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna\u0026#39;s compensation package also includes benefits, stock options, and annual target bonus for full-time positions.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.\u0026lt;/em\u0026gt;\u0026lt;em\u0026gt;\u0026amp;nbsp;\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;div style=\u0026quot;line-height: 1;\u0026quot;\u0026gt;\u0026amp;nbsp;\u0026lt;/div\u0026gt;\n\u0026lt;div style=\u0026quot;line-height: 1;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;Septerna participates in the E-Verify program.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;em\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;California Consumer Privacy Act Privacy Notice For Job Applicants.\u0026amp;nbsp; If you are a California resident, click \u0026lt;a href=\u0026quot;https://septerna.com/california-consumer-privacy-act-privacy-notice-for-job-applicants/\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;here\u0026lt;/a\u0026gt; for our CCPA Notice.\u0026lt;/span\u0026gt;\u0026lt;/em\u0026gt;\u0026lt;/div\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4020407008,"name":"5100 - Manufacturing : Manufacturing","child_ids":[],"parent_id":4020406008}],"offices":[{"id":4007635008,"name":"Septerna Headquarters","location":"South San Francisco, California, United States","child_ids":[4008667008],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/septerna/jobs/5218595008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"education":"education_required","internal_job_id":4474075008,"location":{"name":"South San Francisco, California, United States"},"metadata":null,"id":5218595008,"updated_at":"2026-05-13T08:46:34-04:00","requisition_id":"111","title":"Staff Scientist, Pharmaceutical Development","company_name":"Septerna","first_published":"2026-05-13T08:46:22-04:00","language":"en","application_deadline":null,"content":"\u0026lt;div class=\u0026quot;content-intro\u0026quot;\u0026gt;\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;For more information see: \u0026lt;a href=\u0026quot;http://www.septerna.com\u0026quot;\u0026gt;www.septerna.com\u0026lt;/a\u0026gt;.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;THE ROLE\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are seeking an experienced Staff Scientist with expertise in formulation development to support our small molecule pipeline. They will ensure that fit for purpose formulations are used for nonclinical in vivo studies. They will design, execute, manage, and analyze studies to develop and deliver formulations that support nonclinical DMPK, pharmacology, and toxicology studies. They may also support the development of clinical formulations.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;This position reports to the Director of Pharmaceutical Development is an onsite position requiring in-person collaboration with cross-functional teams.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Develop early formulation strategies and serve as an SME to deliver fit-for-purpose formulations supporting PK, PD, efficacy, and safety preclinical studies through discovery to candidate selection across research programs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Design, manage, and execute early formulation screening studies to enable high-quality in vivo data, including solubility assessments, excipient compatibility, enabling approaches, and stability.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Implement early formulation development and preparation workflows, tools, templates, and best practices internally and in partnership with CDMOs/CROs to support preclinical studies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Represent early formulation on cross-functional research teams, presenting data and recommendations to ensure aligned and timely support.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Author and review technical documents to support early formulation activities and preclinical studies, including development reports and study protocols.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Manage multiple priorities in a fast-paced, dynamic environment and enact quick problem solving to ensure on-time supply of formulations to support preclinical studies across programs.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;A PhD, MS, or BS in Pharmaceutics, Pharmaceutical Sciences, Chemical Engineering, or a related field with a minimum of 6 years, 10 years, or 12 years, respectively, of relevant industry experience in small molecule formulation development.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated success delivering formulation strategies to support preclinical research studies using data-driven, risk‑based strategies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in small molecule formulation development across multiple routes of administration, including powders, solid dosage forms, solutions, suspensions, nanoparticles, and lipid‑based systems.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Hands-on experience with analytical techniques to support small molecule formulation development, including UPLC/HPLC and solid-state characterization techniques (e.g., particle size analysis, DSC, DVS, PLM, and XRPD).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Working knowledge and practical application of current industry and compendial standards and regulatory authority guidance and expectations, including ICH, FDA, MHRA, and EMA guidelines and USP-NF, Ph. Eur, BP, and JP compendia.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to manage and collaborate with external partners, including consultants and CDMOs/CROs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent interpersonal and communication skills (written and oral) with the ability to effectively prepare high-quality technical documentation and concisely present data to peers, management, and external groups.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Exhibited strong organizational and critical thinking skills with an attention to detail and data integrity enabling sound, technically driven decision making.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Able to travel domestically and internationally as needed, up to 20% of the time.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The anticipated salary range for candidates who will work in South San Francisco, CA is $160,000 - $180,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna\u0026#39;s compensation package also includes benefits, stock options, and annual target bonus for full-time positions.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.\u0026lt;/em\u0026gt;\u0026lt;em\u0026gt;\u0026amp;nbsp;\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;div style=\u0026quot;line-height: 1;\u0026quot;\u0026gt;\u0026amp;nbsp;\u0026lt;/div\u0026gt;\n\u0026lt;div style=\u0026quot;line-height: 1;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;Septerna participates in the E-Verify program.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;em\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;California Consumer Privacy Act Privacy Notice For Job Applicants.\u0026amp;nbsp; If you are a California resident, click \u0026lt;a href=\u0026quot;https://septerna.com/california-consumer-privacy-act-privacy-notice-for-job-applicants/\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;here\u0026lt;/a\u0026gt; for our CCPA Notice.\u0026lt;/span\u0026gt;\u0026lt;/em\u0026gt;\u0026lt;/div\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4020408008,"name":"5200 - Manufacturing : Formulation","child_ids":[],"parent_id":4020406008}],"offices":[{"id":4007635008,"name":"Septerna Headquarters","location":"South San Francisco, California, United States","child_ids":[4008667008],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/septerna/jobs/5185908008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"education":"education_required","internal_job_id":4458236008,"location":{"name":"South San Francisco, California, United States"},"metadata":null,"id":5185908008,"updated_at":"2026-04-12T10:55:24-04:00","requisition_id":"109","title":"Vice President, Clinical Development","company_name":"Septerna","first_published":"2026-04-12T10:55:12-04:00","language":"en","application_deadline":null,"content":"\u0026lt;div class=\u0026quot;content-intro\u0026quot;\u0026gt;\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;For more information see: \u0026lt;a href=\u0026quot;http://www.septerna.com\u0026quot;\u0026gt;www.septerna.com\u0026lt;/a\u0026gt;.\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;\u0026lt;div\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;About The Role\u0026lt;/strong\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Septerna has an exciting new opportunity to join the team as a Vice President, Clinical Development, reporting to the Chief Medical Officer. The VP, Clinical Development will join the Senior Leadership Team and provide key strategic leadership for clinical development strategy, planning, and tactical implementation for all clinical development functions. This position will also serve as the Product Development Team Leader (PDTL) for one or more of Septerna’s clinical stage programs. The PDTL is responsible for product strategy and the design and successful cross-functional implementation of the development plan. S/he will also participate in regulatory interactions and contribute to building relationships with KOLs. Ability to bridge clinical, scientific, and business needs with the aptitude to translate and align business and scientific goals and objectives. Must be a dynamic leader with outstanding strategic, communication, and collaboration skills.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;strong\u0026gt;Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Enterprise leader of program strategy, collaborating in a matrixed working environment with clinical operations, regulatory, clinical pharmacology, research, CMC, and other functions to ensure the success of drug development programs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Work with key internal and external stakeholders to lead the design and implementation of robust CDPs and integrated development plans to achieve the desired target product profile.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Guide the development team(s) with aggressive, creative, but realistic approaches to drug development.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Direct and design fit-for-purpose clinical trials across all phases in drug development; design and draft protocol synopses, clinical trial protocols, amendments, and supporting documents.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Contribute to IBs, regulatory documents, CSRs, and publications associated with clinical trials.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide medical oversight of multiple clinical studies and provide medical input and guidance on scientific, clinical and safety monitoring issues.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Be accountable via collaboration across functions and clinical operations for all relevant timelines and deliverables.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborate with regulatory affairs to develop high-quality strategic regulatory strategies and engagement.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Communicate to management and relevant functions any potentially significant issues to the CDP or emerging safety risks in a timely manner.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide strategic consultation and guidance to Research on decision that have significant clinical components and implications.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ensure compliance with SOPs, ICH, GCP, and other national and international regulatory requirements.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;In conjunction with the Chief Medical Officer, ensure organizational growth plans for clinical Development scales with Septerna’s current and future needs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Mentor and develop more junior physicians and other clinical development staff to successfully advance to higher levels of responsibility.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Travel to clinical sites, conferences, and regulatory meetings as needed.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;MD or MD/PhD required and 10+ years of experience in Clinical Development or related pharmaceutical capacity.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Endocrinology/Board Certified Endocrinologist preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven track record of drug development in multiple therapeutic areas.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Rare disease experience is preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent communicator with team building and collaboration skills.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;In depth knowledge of drug development process and oversight of clinical trials; well versed in first-in-human trials as well as late phase development and product filing/ registration.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Has seen and managed significant accelerations and challenges in clinical programs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Outstanding management skills a must, both with respect to managing the development team but also evidence of successful enterprise/matrix leadership.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated ability to lead cross-functional teams to make significant recommendations and persuasively present synthesis of team diligence to gain alignment with senior management.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Expertise in innovative clinical trial design, scientific writing, and the successful implementation of clinical protocols and clinical study reports.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in all phases of regulatory submissions and interactions; international experience also required, along with negotiation experience with the FDA.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Comprehensive knowledge of Good Clinical Practices (GCP), ICH, ICJME Guidelines, FDA and other international regulatory body requirements.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Superb presentation skills.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Thrives in a highly entrepreneurial biotech environment.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/div\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The anticipated salary range for candidates who will work in South San Francisco, CA is $380,000 - $420,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna\u0026#39;s compensation package also includes benefits, stock options, and annual target bonus for full-time positions.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.\u0026lt;/em\u0026gt;\u0026lt;em\u0026gt;\u0026amp;nbsp;\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;div class=\u0026quot;content-conclusion\u0026quot;\u0026gt;\u0026lt;div style=\u0026quot;line-height: 1;\u0026quot;\u0026gt;\u0026amp;nbsp;\u0026lt;/div\u0026gt;\n\u0026lt;div style=\u0026quot;line-height: 1;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;Septerna participates in the E-Verify program.\u0026amp;nbsp; \u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;em\u0026gt;\u0026lt;span style=\u0026quot;font-size: 8pt;\u0026quot;\u0026gt;California Consumer Privacy Act Privacy Notice For Job Applicants.\u0026amp;nbsp; If you are a California resident, click \u0026lt;a href=\u0026quot;https://septerna.com/california-consumer-privacy-act-privacy-notice-for-job-applicants/\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;here\u0026lt;/a\u0026gt; for our CCPA Notice.\u0026lt;/span\u0026gt;\u0026lt;/em\u0026gt;\u0026lt;/div\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\u0026lt;/div\u0026gt;","departments":[{"id":4020399008,"name":"3100 - Development : Clinical science","child_ids":[],"parent_id":4020405008}],"offices":[{"id":4007635008,"name":"Septerna Headquarters","location":"South San Francisco, California, United States","child_ids":[4008667008],"parent_id":null}]}],"meta":{"total":6}}