{"jobs":[{"absolute_url":"https://job-boards.greenhouse.io/seaporttherapeutics/jobs/5230032008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4479532008,"location":{"name":"Boston, MA"},"metadata":null,"id":5230032008,"updated_at":"2026-05-28T12:06:11-04:00","requisition_id":null,"title":"Clinical Trial Manager","company_name":"Seaport Therapeutics","first_published":"2026-05-24T11:42:11-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;Seaport Therapeutics is a clinical-stage biopharmaceutical company advancing the development of novel neuropsychiatric medicines in areas of high unmet patient needs. The Company has a proven strategy of advancing clinically validated mechanisms previously held back by limitations that are overcome with its proprietary Glyph\u0026lt;sup\u0026gt;TM\u0026lt;/sup\u0026gt;\u0026amp;nbsp;technology platform. All the therapeutic candidates in its pipeline of first and best-in-class medicines are based on the Glyph platform, which is uniquely designed to enable oral bioavailability, bypass first-pass metabolism and reduce hepatotoxicity and other side effects. Seaport is led by an experienced team that invented and advanced important neuropsychiatric medicines and are guided by an extensive network of renowned scientists, clinicians and key opinion leaders. For more information, please visit\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://www.seaporttx.com/\u0026quot;\u0026gt;www.seaporttx.com\u0026lt;/a\u0026gt;.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Seaport Therapeutics is seeking a Clinical Trial Manager to join our Development team. The Clinical Trials Manager (CTM) is responsible for leading the execution of clinical studies on schedule and on budget.The ideal candidate will embrace a collaborative, innovative culture that embodies our values of\u0026amp;nbsp;\u0026lt;em\u0026gt;service \u0026lt;/em\u0026gt;to patients impacted by mental health conditions, with a \u0026lt;em\u0026gt;“we own it”\u0026lt;/em\u0026gt; mentality, demonstrating entrepreneurial spirit and technical excellence while fostering teamwork and continuous improvement. This position is based in Boston’s Seaport area, with a strong preference for being onsite 4 days per week.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Accountable for project related efforts for the delivery of studies that are critical to a product’s clinical development, ensuring that they are completed on time, within budget and in compliance with SOPs, regulations and ICH/GCP guidelines.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Supports external vendor selection and management process and assists in the development of RFP’s and vendor oversight plans.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Responsible for management of CROs and other vendors\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide input for the design of the Informed Consent Form(s), eCRFs, monitoring conventions, edit checks, etc.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop timelines and budgets for assigned studies and is responsible for delivery to both quality and agreed timelines.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Project leadership of the cross-functional study team, including external team members, CROs and vendors.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Plan, negotiate, and manage site budgets as well as facilitate site contracting process.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop and implement robust contingency and issue management plans to solve complex issues that impact study milestones.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Disseminate clinical trial communications to all functional groups and leads study and team meetings.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Interact with clinical research investigators, Key Opinion Leaders and sites.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;May interact with Senior Management to report on progress of milestones.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversight of study team and site training\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Facilitation of Quality processes and Quality Assurance interactions for assigned project(s)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Management of study drug distribution and accountability processes and documentation\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversight of study start-up, study management, data cleaning, and study closeout activities\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Responsible for final study files and documentation, including TMF, final TLFs, and final study data archival\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provides review, assistance or leadership for the development and writing of study protocols, study plans, CRFs, informed consent forms.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;BA/BS degree in Health or Life Sciences required\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Minimum 4+ years of experience or demonstration of equivalent capability in a Clinical Trials Manager role\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Exceptional communication and interpersonal skills\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Positive team orientated attitude\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Reliable, self-motivated, team player\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Detail oriented with excellent organizational skills\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to effectively manage multiple tasks and competing priorities\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Creative problem solver\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to travel is required\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;CNS therapeutic experience strongly preferred\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;At Seaport, we believe transparency and fairness are key to building a culture of trust, respect, and collaboration. We care deeply about the happiness of our team and strive to ensure our total rewards (monetary and non-monetary) program reflects the value each person brings. The expected salary range for this role is ($133,000 - $157,000) with the final offer based on experience, market data, and internal equity.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We encourage open conversations with our talent acquisition team about compensation early in the process to ensure alignment from the start.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4050482008,"name":"Clinical Operations","child_ids":[],"parent_id":null}],"offices":[{"id":4007133008,"name":"Boston","location":"Boston, Massachusetts, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/seaporttherapeutics/jobs/5073947008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4405339008,"location":{"name":"Boston, MA"},"metadata":null,"id":5073947008,"updated_at":"2026-01-16T10:22:45-05:00","requisition_id":"22","title":"Director, Statistical Programming","company_name":"Seaport Therapeutics","first_published":"2026-01-16T10:22:45-05:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;Seaport Therapeutics is a clinical-stage therapeutics company advancing the development of novel neuropsychiatric medicines in areas of high unmet patient needs. The Company has a proven strategy of advancing clinically validated mechanisms previously held back by limitations that are overcome with its proprietary GlyphTM\u0026amp;nbsp;technology platform. All the therapeutic candidates in its pipeline of first and best-in-class medicines are based on the Glyph platform, which is uniquely designed to enable oral bioavailability, bypass first-pass metabolism and reduce hepatotoxicity and other side effects. Seaport is led by an experienced team that invented and advanced important neuropsychiatric medicines and are guided by an extensive network of renowned scientists, clinicians and key opinion leaders. For more information, please visit\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://www.seaporttx.com/\u0026quot;\u0026gt;www.seaporttx.com\u0026lt;/a\u0026gt;.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Seaport Therapeutics is hiring our first in-house Statistical Programming leader to build and lead the Statistical Programming function within the Biometrics department. Reporting to the VP, Head of Biometrics, this Director will provide strategic oversight of CRO/vendor programming activities, perform hands-on programming in SAS and R, and ensure high-quality, submission-ready deliverables that meet CDISC and global regulatory standards. In the near term, the role will focus on vendor governance, thorough review/QC of datasets and TLFs, and support for regulatory interactions, publications, and ongoing medical/safety monitoring. Longer term, this leader will establish processes and SOPs, recruit and develop a high-performing team, and serve as a key member of the Biometrics leadership team driving continuous improvement.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The ideal candidate will embrace a collaborative, innovative culture that embodies our values of \u0026lt;em\u0026gt;service \u0026lt;/em\u0026gt;to patients impacted by mental health conditions, with a \u0026lt;em\u0026gt;“we own it”\u0026lt;/em\u0026gt; mentality, demonstrating entrepreneurial spirit and technical excellence while fostering teamwork and continuous improvement. This position is based in Boston’s Seaport area, with a strong preference for being onsite 4 days per week.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Lead the Statistical Programming function for Seaport Therapeutics; serve as programming representative on study and program teams and within the Biometrics leadership group.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide strategic oversight and day-to-day governance of CROs and external programmers, including scope planning, timelines, quality metrics, and issue escalation.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Perform hands-on programming in SAS or R to review/QC vendor deliverables, develop analysis datasets (SDTM/ADaM), and generate tables, listings, and figures (TLFs).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ensure compliance with CDISC standards (SDTM, ADaM), FDA/EMA/ICH guidance, and submission requirements (e.g., define.xml, reviewer’s guides, eCTD packages).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support regulatory interactions (IND, NDA/BLA/MAA), including ad hoc analyses, briefing package outputs, and responses to information requests.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partner with Biostatistics, Data Management, Clinical, and Safety to enable medical and safety monitoring, signal detection, and data-driven decision-making across ongoing trials.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Establish and maintain programming processes, SOPs, work instructions, and reusable libraries/macros; champion automation, reproducibility, and audit readiness.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Recruit, manage, mentor, and develop a team of statistical programmers as the portfolio grows; manage contractors/FSPs and oversee performance and career development.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Drive continuous improvement across standards, tools, and infrastructure (SAS/R environments, version control, code review practices) in collaboration with IT and QA.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Plan and manage resources and budgets for programming activities; contribute to vendor selection, governance frameworks, and performance/quality measures for delivery quality and timeliness.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Represent Statistical Programming in inspections and audits; ensure documentation completeness and compliance with 21 CFR Part 11, GCP, data privacy, and company SOPs.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Advanced degree (MS/PhD) in Statistics, Biostatistics, Computer Science, Mathematics, or related discipline; BS with strong relevant experience considered.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;10+ years of statistical programming experience in biotech/pharma/CRO settings, with 5+ years of people management.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Expert hands-on proficiency in SAS (Base, Macro, STAT, GRAPH, SQL) and strong working knowledge of R; experience with Python is a plus.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated experience overseeing CROs/vendors and validating programming deliverables to CDISC standards (SDTM, ADaM).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven contribution to global submissions (e.g., NDA/BLA/MAA), including submission-ready datasets, TLFs, define.xml, reviewer’s guides, and CSR appendices.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong understanding of clinical development processes, ICH/GCP, FDA/EMA guidelines, and 21 CFR Part 11 compliance.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Track record of building teams, establishing SOPs and standards, and implementing automation and best practices for efficiency and quality.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent communication, collaboration, and leadership skills; ability to translate technical concepts for non-technical stakeholders.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Therapeutic area experience in CNS/neuropsychiatry is a plus; passion for Seaport’s patient-centric mission is essential.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;At Seaport, we believe transparency and fairness are key to building a culture of trust, respect, and collaboration. We care deeply about the happiness of our team and strive to ensure our total rewards (monetary and non-monetary) program reflects the value each person brings. The expected salary range for this role is $198,000-233,000 with the final offer based on experience, market data, and internal equity. We encourage open conversations with our talent acquisition team about compensation early in the process to ensure alignment from the start.\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h1\u0026gt;\u0026amp;nbsp;\u0026lt;/h1\u0026gt;","departments":[{"id":4050479008,"name":"Biometrics","child_ids":[],"parent_id":null}],"offices":[{"id":4007133008,"name":"Boston","location":"Boston, Massachusetts, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/seaporttherapeutics/jobs/5062990008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4400522008,"location":{"name":"Boston, MA"},"metadata":null,"id":5062990008,"updated_at":"2026-02-27T10:52:20-05:00","requisition_id":"18","title":"Executive Director/Vice President, Clinical Development","company_name":"Seaport Therapeutics","first_published":"2026-01-09T16:03:45-05:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Seaport Therapeutics is a clinical-stage therapeutics company advancing the development of novel neuropsychiatric medicines in areas of high unmet patient needs. The Company has a proven strategy of advancing clinically validated mechanisms previously held back by limitations that are overcome with its proprietary GlyphTM technology platform. All the therapeutic candidates in its pipeline of first and best-in-class medicines are based on the Glyph platform, which is uniquely designed to enable oral bioavailability, bypass first-pass metabolism and reduce hepatotoxicity and other side effects. Seaport is led by an experienced team that invented and advanced important neuropsychiatric medicines and are guided by an extensive network of renowned scientists, clinicians and key opinion leaders. For more information, please visit www.seaporttx.com.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Seaport Therapeutics is seeking a hands-on clinical development leader to drive the strategic and operational execution of our global clinical programs across current and future pipeline assets. This role will report to the Chief Medical Officer and oversee clinical trial design and execution, partner with regulatory strategy, biostatistics, program management and other cross-functional stakeholders and external partners including regulatory agencies, KOLs, and investigators. The ideal candidate will bring deep expertise in neuroscience or neurology, a proven track record of successful IND/NDA submissions, experience with Ph III clinical development, and a passion for partnering with high-performing teams and advancing innovative therapies in neurological and neuropsychiatric diseases.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The ideal candidate will embrace a collaborative, innovative culture that embodies our values of service to patients impacted by mental health conditions, with a “we own it” mentality, demonstrating entrepreneurial spirit and technical excellence while fostering teamwork and continuous improvement. This position is based in Boston’s Seaport area, with a strong preference for being onsite 4 days per week.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Primary Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Establish and drive the clinical development strategy and hands-on tactical execution plans on programs against the current and future development portfolio.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Manage effective internal and external relationships, internally with members of the executive leadership team, regulatory affairs, clinical operations and medical affairs, and externally including regulatory agencies, partners, KOLs, and investigators.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Medical oversight of ongoing clinical trials in the neuropsychiatric therapeutic area.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Lead clinical sections of regulatory documents (IND, BLA/NDA).\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Work with Regulatory Affairs to prepare for meetings with FDA and healthcare authorities.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Work with Scientific Communications/ Medical Affairs team members to organize and prepare for advisory board meetings.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Work with other members of the Program team through all phases of development through commercialization.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Prioritize and develop the company’s current drug candidates as well as future pipeline compounds and contribute to go / no-go decisions.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Literature review, KOL interactions, attending scientific meetings, and presenting the clinical development plan to the relevant internal stakeholders to help shape the new indication selection process.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Ensure that standard operating procedures (SOP) for Clinical Development facilitate the development of effective clinical research protocols and are compliant with clinical/medical and industry standards.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Actively participate in strategic planning for the clinical development organization and provide support to business development / licensing activities.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Maintain an understanding of competitors and clinical developments in relevant therapeutic areas.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Build and maintain medical advisory boards based on solid working relationships with KOLs and lead clinical investigators.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Requirements\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· MD training in psychiatry and/or neuroscience required.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· 8+ (ED) 10+(VP) years of clinical development experience within a biotech/pharmaceutical setting with a strong track record of successful clinical program execution in the field of neuropsychiatric drug development. Prior clinical/academic experience required as well.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Experience with mood/anxiety disorders preferred.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Experience with GCP/ICH/FDA requirements, clinical trial design and strategies, interpretation of clinical data and generation of supporting regulatory submissions of clinical study documents.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Demonstrated track record and experience working cross-functionally in a collaborative and productive manner across R\u0026amp;amp;D functions and beyond.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Exceptional interpersonal, influencing, presentation, and written and verbal communication skills.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Experience with successful NDA submissions and approvals and interactions with regulatory agencies are highly desired.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Experience with Phases I-III clinical development required.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Understanding of the general healthcare environment in the US and elsewhere-including laws, regulations, and evolving market access trends and issues.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Knowledge and experience of building clinical development infrastructure aligned with the needs of a growing organization.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;· Occasional work travel as required.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;At Seaport, we believe transparency and fairness are key to building a culture of trust, respect, and collaboration. We care deeply about the happiness of our team and strive to ensure our total rewards (monetary and non-monetary) program reflects the value each person brings. The expected salary range for this role at the Executive Director Level is $297,000-$340,000 $the expected salary range for the role at the Vice President Level is $324,000-370,000 with the final title and offer based on experience, market data, and internal equity.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We encourage open conversations with our talent acquisition team about compensation early in the process to ensure alignment from the start.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4050481008,"name":"Clinical Development","child_ids":[],"parent_id":null}],"offices":[{"id":4007133008,"name":"Boston","location":"Boston, Massachusetts, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/seaporttherapeutics/jobs/5181453008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4456533008,"location":{"name":"Boston, MA"},"metadata":null,"id":5181453008,"updated_at":"2026-04-08T16:04:15-04:00","requisition_id":"30","title":"Senior Director, Analytical Research \u0026 Development","company_name":"Seaport Therapeutics","first_published":"2026-04-08T16:04:15-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;Seaport Therapeutics is a clinical-stage therapeutics company advancing the development of novel neuropsychiatric medicines in areas of high unmet patient needs. The Company has a proven strategy of advancing clinically validated mechanisms previously held back by limitations that are overcome with its proprietary Glyph™ technology platform. All the therapeutic candidates in its pipeline of first and best-in-class medicines are based on the Glyph platform, which is uniquely designed to enable oral bioavailability, bypass first-pass metabolism and reduce hepatotoxicity and other side effects. Seaport is led by an experienced team that invented and advanced important neuropsychiatric medicines and are guided by an extensive network of renowned scientists, clinicians and key opinion leaders. For more information, please visit www.seaporttx.com.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Seaport Therapeutics is seeking someone to lead analytical research and development for its portfolio of small molecule programs targeting neuropsychiatric disorders.\u0026amp;nbsp; The Senior Director, Analytical R\u0026amp;amp;D, reports to the Vice President, CMC and is responsible for providing strategic and technical leadership for analytical development of small molecules within Seaport’s portfolio, from pre-clinical development to late-stage clinical development. This includes oversight of analytical method development, validation, method transfer to CMO’s, and support of regulatory filings, including investigational new drugs (INDs)/investigational medicinal product dossier (IMPDs) and new drug applications (NDAs). The role also includes strategic partnering with Quality, Development \u0026amp;amp; Manufacturing, and Regulatory to deliver uninterrupted clinical supplies to enable Seaport’s current and future clinical studies.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The role will be accountable for delivering analytical methods that are phase-appropriate and adhere to the highest scientific standards. The successful candidate must be able to collaborate in a fast-paced, integrated, multidisciplinary team environment. Research and industry experience should demonstrate successful application and management of state-of-the-art analytical techniques to solve problems, in addition to several years’ experience overseeing analytical development at CMO’s.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The position is responsible for ensuring that all method development, validation and testing (release, stability, and other) performed on behalf of Seaport is conducted in accordance with the appropriate compendial standards, when available, and is compliant to all regulations and industry phase-appropriate testing standards and standard operating procedures.\u0026amp;nbsp; The Senior Director will also ensure that all testing and testing services coordinate with all other product development activities so that testing does not fall on the critical path and causes product development delays.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The ideal candidate will embrace a collaborative, innovative culture that embodies our values of service to patients impacted by mental health conditions, with a \u0026#39;we own it\u0026#39; mentality, demonstrating entrepreneurial spirit and technical excellence while fostering teamwork and continuous improvement.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Serve as the functional head of Analytical Research \u0026amp;amp; Development, accountable for analytical strategy across Seaport’s small‑molecule portfolio from preclinical through late‑stage clinical development.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Define and implement phase‑appropriate analytical development strategies for drug substance (DS) and drug product (DP), aligned with overall CMC and regulatory objectives.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead and develop the Analytical function within CMC, including direct management of analytical staff and thoughtful planning for future capability needs as the portfolio advances.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Establish best practices for analytical lifecycle management, data integrity, documentation, and knowledge transfer.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Define and execute Seaport’s outsourced analytical strategy, including selection, onboarding, governance, and performance management of CDMOs and contract testing laboratories.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide strategic oversight and day‑to‑day governance of CDMO’s, ensuring adherence to scope, timelines, quality standards, and data integrity expectations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide technical leadership for analytical method development, validation, and transfer for DS and DP, utilizing techniques including (but not limited to) HPLC-CAD, HPLC-UV, GC, LC-MS, LC‑MS/MS, HPLC-FLR, LC-qToF, GC (Residual Solvents), Elemental impurity analysis, IR, qNMR, thermal analysis, droplet size, PSD, lipolysis, and dissolution/ drug release.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ensure analytical methods and specifications are scientifically justified, phase‑appropriate, and compliant with applicable compendial standards and regulatory guidelines.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Review and approve analytical methods, validation protocols, analytical reports, stability protocols, and stability test reports.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversee stability programs, including trending and proactive identification of potential quality or stability issues.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborate closely with QA, Regulatory Affairs, Development \u0026amp;amp; Manufacturing, Clinical Supply, and Research to ensure alignment across development activities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ensure analytical activities are integrated into overall project plans and do not become a critical path for development timelines.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide analytical CMC leadership for regulatory filings, including INDs, IMPDs, NDAs, and MAAs, with direct responsibility for authoring and reviewing analytical sections.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partner with Quality Assurance to support audits of external testing facilities and contribute to Quality and Service Agreements.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Professional Experience/Qualifications:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;MS or Ph.D. in Analytical Chemistry, Physical Chemistry, or a related scientific discipline.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;12–15+ years of progressive industry experience in small‑molecule analytical development within pharmaceutical or biotechnology organizations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated experience leading analytical development across multiple development stages, including late‑stage clinical development and registration‑enabling activities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven experience serving as a functional or sub‑functional leader, including people leadership and accountability for analytical strategy execution.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Extensive hands‑on expertise in chromatographic and spectroscopic techniques, including GC, LC, IC, chiral separations, and detection methods such as UV/Vis, CAD, MS (SIM/MRM), fluorescence, FID, and ECD.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience managing analytical development and testing activities through CDMOs and contract laboratories in a virtual or highly outsourced operating model.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong knowledge of global regulatory requirements and ICH guidelines applicable to analytical development and control strategies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with complex lipophilic drug substances and formulations, including enabling formulation approaches (e.g., SEDDS, soft‑gel dosage forms).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated ability to lead and influence cross‑functional teams in a fast‑paced, resource‑constrained biotech environment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent communication, collaboration, and scientific judgment skills, with the ability to make sound decisions balancing speed, quality, and regulatory expectations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Willingness to travel internationally approximately 25% of the time.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;At Seaport, we believe transparency and fairness are key to building a culture of trust, respect, and collaboration. We care deeply about the happiness of our team and strive to ensure our total rewards (monetary and non-monetary) program reflects the value each person brings. The expected salary range for this role is \u0026lt;strong\u0026gt;$230,000–$270,000\u0026lt;/strong\u0026gt;, with the final offer based on experience, market data, and internal equity. We encourage open conversations with our talent acquisition team about compensation early in the process to ensure alignment from the start.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4050484008,"name":"CMC","child_ids":[],"parent_id":null}],"offices":[{"id":4007133008,"name":"Boston","location":"Boston, Massachusetts, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/seaporttherapeutics/jobs/5230035008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4479533008,"location":{"name":"Boston, MA"},"metadata":null,"id":5230035008,"updated_at":"2026-05-24T11:47:26-04:00","requisition_id":"32","title":"Senior/Executive Director, Corporate Counsel","company_name":"Seaport Therapeutics","first_published":"2026-05-24T11:47:26-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;Seaport Therapeutics is a clinical-stage therapeutics company advancing the development of novel neuropsychiatric medicines in areas of high unmet patient needs. The Company has a proven strategy of advancing clinically validated mechanisms previously held back by limitations that are overcome with its proprietary Glyph\u0026lt;sup\u0026gt;TM\u0026lt;/sup\u0026gt;\u0026amp;nbsp;technology platform. All the therapeutic candidates in its pipeline of first and best-in-class medicines are based on the Glyph platform, which is uniquely designed to enable oral bioavailability, bypass first-pass metabolism and reduce hepatotoxicity and other side effects. Seaport is led by an experienced team that invented and advanced important neuropsychiatric medicines and are guided by an extensive network of renowned scientists, clinician\u0026amp;nbsp; s and key opinion leaders. For more information, please visit\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://www.seaporttx.com/\u0026quot;\u0026gt;www.seaporttx.com\u0026lt;/a\u0026gt;.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Seaport Therapeutics is seeking a talented and experienced \u0026lt;strong\u0026gt;Senior/Executive Director, Corporate Counsel \u0026lt;/strong\u0026gt;to provide legal support across securities law compliance, corporate governance, and transactional matters. This role reports to the General Counsel and works closely with cross-functional teams, including Finance, Investor Relations, and Communications, and R\u0026amp;amp;D, as well as supporting Board-related activities, in a collaborative, science-driven organization. This is an opportunity to take on a broad, impactful role at a growing public therapeutics company, with exposure to executive leadership and Board-level processes and involvement in financings, strategic transactions, and governance initiatives. This role will be the lead securities counsel role supporting all core SEC reporting and public company disclosure activities. This role will have direct exposure to executive leadership and Board processes, including preparation of Board and committee materials. This role will have broad scope across governance, compliance, and disclosure, with the opportunity to help shape evolving public company practices.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;This position requires a presence in the Seaport area of Boston, with a strong preference for being onsite 4 days per week. The role will report to the General Counsel.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Draft and provide counsel in support of SEC filings, including Forms 10-K, 10-Q, and 8-K, proxy statements, and Section 16 filings (Forms 3, 4, and 5), and related public company disclosures\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead corporate disclosure processes and controls, working with internal stakeholders to ensure consistency, accuracy, and timeliness\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Assist in the preparation and review of earnings materials, press releases, and other external communications to ensure compliance with public company disclosure requirements\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Assist with coordination of Board of Directors and committee materials and related governance processes\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead the Company’s public company compliance efforts related to securities law, disclosure practices, and corporate governance, in partnership with the General Counsel\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Maintain and administer insider trading compliance programs, including Rule 10b5-1 plans and trading window processes\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead the development and maintenance of corporate governance documents, policies, and procedures\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide legal support for equity compensation programs and related documentation\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partner with cross-functional stakeholders (including Legal, Finance, Investor Relations, and R\u0026amp;amp;D) to provide practical guidance on regulatory requirements and help operationalize disclosure and governance practices\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Contribute to governance, compliance, and ESG-related initiatives, including evolving disclosure and policy development\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support corporate transactions, including financings, strategic collaborations, and M\u0026amp;amp;A activity, as needed\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Assist with due diligence processes and management of data rooms\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Manage and coordinate external legal counsel where appropriate\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Juris Doctor (J.D.) from an accredited U.S.\u0026amp;nbsp; law school\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;10-15 years of relevant experience, including SEC reporting and public company matters at a large law firm and/or as in-house\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in biotechnology or pharmaceutical companies preferred\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Familiarity with clinical-stage or emerging growth companies is advantageous\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience supporting senior leadership and Board-related processes is a plus\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Candidates with a blend of law firm and in-house experience are particularly encouraged to apply.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong knowledge of U.S. securities laws, SEC and Nasdaq reporting requirements, and corporate governance practices, particularly in the life sciences sector\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to manage multiple priorities in a deadline-driven environment\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong written and verbal communication skills, with the ability to work effectively across functions\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Sound judgment and attention to detail in handling sensitive and confidential matters\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborative approach, with the ability to operate both independently and as part of a team\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong sense of ownership and the ability to operate effectively in a lean, high-performing environment\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to handle confidential and proprietary information with discretion\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;br\u0026gt;At Seaport, we believe transparency and fairness are key to building a culture of trust, respect, and collaboration. We care deeply about the happiness of our team and strive to ensure our total rewards (monetary and non-monetary) program reflects the value each person brings. The expected salary range for this role at the Senior Director level is $270,000 - $300,000. The expected salary range for this role at the Executive Director level is $295,000-$330,000 with the final offer based on experience, market data, and internal equity.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We encourage open conversations with our talent acquisition team about compensation early in the process to ensure alignment from the start.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4050472008,"name":"Legal","child_ids":[],"parent_id":null}],"offices":[{"id":4007133008,"name":"Boston","location":"Boston, Massachusetts, United States","child_ids":[],"parent_id":null}]}],"meta":{"total":5}}