{"jobs":[{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/5807853004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5053946004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":5807853004,"updated_at":"2026-10-23T17:24:35-04:00","requisition_id":"51","title":"Lab Operations Manager","company_name":"General Proximity","first_published":"2026-02-18T18:18:34-05:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; Lab Operations Manager to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking an experienced Lab Operations Manager to support our Biology, Chemistry, and Platform teams. In this position, you will work at the intersection of lab management, operations, and biological research. \u0026lt;strong\u0026gt;This job requires strong skills and demonstrable experience in all three areas: lab management, operations, and cell/molecular biology\u0026lt;/strong\u0026gt;.\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Your responsibilities will include 1) general lab management: maintaining lab stocks, inventories and ordering, registering and preparing compound stocks, preparing buffers/media, and receiving supplies; 2) operations: procurement, vendor and service relationships, equipment acquisition and maintenance, and EHS compliance and lab safety; and 3) biological research: maintaining cell lines and performing cell-based assays alongside our scientists. You will also train new team members on our assays and lab systems, or coordinate that training.\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;This is a full-time, onsite role in San Francisco.\u0026amp;nbsp;\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Systems-Minded.\u0026lt;/strong\u0026gt; You build processes that keep running when you\u0026#39;re not in the room and can scale with company growth.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;BS in Biology or related life sciences field, with a minimum of 2 years of experience maintaining laboratory operations, ideally supporting a group of 10+ scientists.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Excellent attention to detail, strong organizational and problem-solving skills, and clear written and interpersonal communication.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Track record of building lab systems and processes that run reliably and scale as the company grows.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience managing sample inventories, vendors, EHS compliance, and lab safety.\u0026lt;/span\u0026gt;\u0026lt;br\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Proficiency in:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Lab inventory management, ordering, and receiving for reagents and consumables across multiple teams\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Procurement and vendor management, including quotes, purchase orders, and pricing negotiations\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Equipment maintenance and troubleshooting (biosafety cabinets, incubators, LN2 storage), including service contracts and preventive maintenance\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;EHS programs, including chemical and biological waste, hazardous materials tracking, and safety training\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Registration of inventory and compound stock preparation\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Mammalian cell culture, including passaging, seeding, and cryopreserving cell lines\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Nice to have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience with Quartzy, Benchling, Science Exchange, Ramp, and Happilabs is a bonus\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience setting up or administering LIMS/inventory database systems\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience leading or coordinating a lab move or new lab build-out\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience operating liquid handlers or other lab automation\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience with compound management\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience running cell-based assays in multi-well plate formats\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Plasmid design/cloning and PCR\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Transient/stable protein expression and characterization, and immunoprecipitation assays\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Any computational or programming skills (e.g., Python or R) would also be a bonus\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;em\u0026gt;\u0026lt;strong\u0026gt;You don\u0026#39;t need to check every box. If this role excites you, we\u0026#39;d like to hear from you.\u0026lt;/strong\u0026gt;\u0026lt;/em\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045438004,"name":"Operations","child_ids":[],"parent_id":null}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/5332718004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4817237004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":5332718004,"updated_at":"2025-12-17T16:41:30-05:00","requisition_id":"39","title":"Other Positions","company_name":"General Proximity","first_published":"2024-09-17T16:52:45-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Other Position(s)\u0026lt;br\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Interested in working with us but don\u0026#39;t see a position that fits? Send us your resume/CV by applying here, and we will add you to our talent pool and reach out once we find a good fit!\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; scientists to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://prox.bio/benefits\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/6009199004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5160212004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":6009199004,"updated_at":"2026-05-29T15:27:15-04:00","requisition_id":"55","title":"Scientist, Mechanistic Biology","company_name":"General Proximity","first_published":"2026-05-29T15:20:56-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; mechanistic\u0026lt;span style=\u0026quot;color: rgb(0, 0, 0);\u0026quot;\u0026gt; biologist\u0026amp;nbsp;\u0026lt;/span\u0026gt;to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking an experienced mechanistic biologist to join our Discovery Biology Team. In this position, you will work closely with our Platform and Chemistry Teams to drive mechanistic understanding of our lead compounds and support core drug discovery efforts. This is an opportunity to help elucidate novel pharmacological mechanisms of our next-gen IPMs.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Your responsibilities will include designing and executing mechanistic studies on hit compounds, dissecting signaling pathways to map compound mechanism of action, interrogating protein-protein interactions, preparing and analyzing NGS libraries, and developing and deploying functional cell-based assays to characterize novel pharmacology.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;BS, MS or PhD in Cell Biology, Biochemistry, or related field.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Candidates without a PhD should have 5-7+ years of relevant industry experience.\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Previous experience elucidating novel biology underlying small-molecule mechanism of action in a drug discovery context.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top-notch written and oral communication skills.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong experience with\u0026lt;/strong\u0026gt;:\u0026lt;/span\u0026gt;\u0026lt;br\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Cellular and molecular biology, including extensive experience with mammalian cell line work and associated assays, stable cell line generation (lentiviral and CRISPR-based systems), co-IP/pull-down assays, RNA-seq, global proteomics, flow cytometry, plasmid design/cloning, etc.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Small molecule drug development campaigns (hit discovery, hit validation, dose-response studies, SAR and MOA studies)\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Mechanistic studies of cell signaling, pathway analysis, and PTM analysis\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Protein-protein interaction techniques (e.g., BRET, APEX/BioID, AlphaScreen, etc.)\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;NGS library prep, sequencing, and analysis\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Nice to have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience with PROTAC/next-gen IPM technologies\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience working at the interface of mechanistic biology and chemistry\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience working on teams that have successfully advanced research to the clinic\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience managing CROs\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045442004,"name":"Discovery Biology","child_ids":[],"parent_id":4045441004}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/6009487004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5160352004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":6009487004,"updated_at":"2026-05-29T18:22:03-04:00","requisition_id":"56","title":"Scientist, Medicinal Chemistry","company_name":"General Proximity","first_published":"2026-05-29T18:15:44-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt;\u0026amp;nbsp;\u0026lt;span style=\u0026quot;color: #e03e2d;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;color: rgb(0, 0, 0);\u0026quot;\u0026gt;medicinal chemist\u0026lt;/span\u0026gt; \u0026lt;/span\u0026gt;to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a medicinal chemist to be a member of our Chemistry/Drug Discovery Team. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Your responsibilities will include designing and optimizing first-in-class bifunctional molecules, assessing SAR to inform iterative medicinal chemistry optimization, supervising synthetic efforts with CRO partners, performing and analyzing in cellulo assays, collaborating with our Drug Discovery and IP teams on patent applications, and contributing mechanistic insight on lead drug molecules.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;PhD in Medicinal Chemistry, Chemical Biology, Pharmacology, or related field.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Industry experience is desirable, but the ability to work hard and learn fast is more important to us.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Deep understanding of small-molecule drug discovery and its relationship to human disease.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Able to work fluently at the interface of chemistry and biology.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top-notch written and oral communication skills.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong experience in:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Design, synthesis, and optimization of induced proximity medicines (e.g. PROTACs or other IPMs)\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Hit-to-lead and lead optimization campaigns\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Multi-step organic synthesis, with a proven ability to design and execute complex synthetic routes toward drug-like small molecules\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Medicinal chemistry optimization: SAR, PK/PD, and strong working knowledge of DMPK principles\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Chemical biology techniques including mammalian cell culture, cell-based assays (e.g., cytotoxicity, transfections, stable cell line generation, co-IP), and PPI assays (e.g., BRET, APEX/BioID, AlphaScreen); computational chemistry experience also welcomed\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Nice to have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;HTS and phenotypic assay development\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc.\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Computational or molecular dynamics drug discovery experience\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;DEL experience\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience managing synthetic chemistry CRO teams\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Prior experience on teams that have successfully advanced research to the clinic\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045440004,"name":"Chemistry Team","child_ids":[],"parent_id":4013330004}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/5660301004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4985104004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":5660301004,"updated_at":"2026-05-19T15:16:46-04:00","requisition_id":"48","title":"Scientist/Sr. Scientist, Chemical Biology","company_name":"General Proximity","first_published":"2025-09-26T15:27:14-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; \u0026lt;span style=\u0026quot;color: rgb(0, 0, 0);\u0026quot;\u0026gt;chemical biologist\u0026lt;/span\u0026gt;\u0026amp;nbsp;to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking an \u0026lt;strong\u0026gt;experienced chemical biologist with medicinal chemistry training to be a founding member of our Chemistry/Drug Discovery Team\u0026lt;/strong\u0026gt;. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Your responsibilities will include: supervising synthetic efforts with our CROs, designing, performing, and analyzing \u0026lt;em\u0026gt;in cellulo\u0026lt;/em\u0026gt; assays, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, providing input for mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;PhD in Chemical Biology, Medicinal Chemistry, Pharmacology, or related field.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt; font-weight: bold;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Chemical Biology with Medicinal Chemistry experience required.\u0026lt;/span\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Industry experience is desirable, but the ability to work hard and learn fast is more important to us.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Deep understanding of small-molecule drug discovery and its relationship to human disease.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Able to work fluently at the interface of chemistry and biology.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top-notch written and oral communication skills.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong experience with:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Designing, synthesizing, and optimizing induced proximity medicines (e.g. PROTACs or other IPMs)\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Contributing to hit-to-lead and lead optimization studies\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Med-chem optimizations: SAR, PK/PD, strong understanding of DMPK\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), and PPI assays (e.g., BRET, APEX/BioID, AlphaScreen)\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Nice to have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Proficiency in HTS and phenotypic assay development\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Computational or molecular dynamics drug discovery experience\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;DEL experience\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience managing others, especially synthetic chemistry CRO teams\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Prior experience on teams that have successfully advanced research to the clinic\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045440004,"name":"Chemistry Team","child_ids":[],"parent_id":4013330004}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/6130243004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5193498004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":6130243004,"updated_at":"2026-07-29T18:37:25-04:00","requisition_id":"58","title":"Scientist/Sr. Scientist, Computational Chemistry ","company_name":"General Proximity","first_published":"2026-07-29T17:25:33-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; \u0026lt;span style=\u0026quot;color: rgb(0, 0, 0);\u0026quot;\u0026gt;computational chemist\u0026lt;/span\u0026gt; to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking an exceptional computational chemist to support our computational chemistry, cheminformatics, and molecular design efforts. This role will help drive small-molecule drug discovery programs by providing practical modeling support, applying modern computational workflows, and using the cheminformatics and AI-enabled tools that empower medicinal chemists and project teams.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;The successful candidate will be a hands-on drug designer: someone who can partner closely with medicinal chemists, structural biologists, biologists, and DMPK scientists to guide compound design from hit identification through lead optimization and candidate selection. They will also apply practical tools that improve decision-making, accelerate design-make-test-analyze\u0026amp;nbsp;cycles, and make computational and AI-driven methods accessible to bench chemists.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;The ideal candidate is a computational drug hunter who combines strong technical expertise with practical medicinal chemistry judgment. This person should not be an isolated modeler, but a true project partner who sits with chemistry teams, understands the design problem, proposes molecules, helps interpret data, and contributes tools that make the broader organization faster and smarter.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;This role is ideal for someone who has worked in a pharma or biotech computational chemistry group and wants to work with modern, AI-enabled computational methods while remaining directly involved in molecule design.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;What You\u0026#39;ll Do\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Computational Chemistry and Molecular Design\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Provide hands-on computational chemistry support to small-molecule discovery programs from target evaluation, hit identification, hit-to-lead, and lead optimization through candidate nomination.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Apply structure-based and ligand-based design approaches to guide compound design, including docking, molecular dynamics, pharmacophore\u0026amp;nbsp;modeling, QSAR, scaffold hopping, virtual screening, FEP/free-energy methods, and multi-parameter optimization.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Use structural biology data, including X-ray structures, cryo-EM structures, homology models, and AlphaFold-derived models, to generate actionable design hypotheses.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Partner with\u0026amp;nbsp;the\u0026amp;nbsp;medicinal chemistry team to interpret SAR,\u0026amp;nbsp;optimize\u0026amp;nbsp;potency, selectivity, physicochemical properties, ADME/PK, developability, and synthetic feasibility.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Contribute to computational design discussions with project teams and translate complex modeling results into clear, practical medicinal chemistry recommendations.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Support portfolio prioritization by evaluating target tractability,\u0026amp;nbsp;ligandability, binding-site quality, chemical matter, and developability risks.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Cheminformatics and Data Infrastructure\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Use and help improve chem and bioinformatics tools that support compound registration, structure-searching, SAR analysis, property visualization, compound triage, library design, and project decision-making.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Apply tools for chemical data handling, including similarity and substructure searching, R-group analysis, matched molecular pairs, reaction enumeration, compound clustering, property prediction, and visualization.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Work with internal or external engineering and data science teams to integrate chemical, biological, DMPK, structural, and assay data into usable project dashboards and design tools.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Follow best practices for chemical data quality, assay data curation, compound annotation, metadata standards, and reproducible computational workflows.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Use commercial and open-source computational tools, including platforms such as Schrödinger, MOE, CCDC tools, ChemAxon, KNIME, Pipeline Pilot, RDKit, DataWarrior, Spotfire, and related systems.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;AI/ML and Digital Chemistry Tools\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Apply\u0026amp;nbsp;\u0026lt;u\u0026gt;user-friendly\u0026lt;/u\u0026gt;\u0026amp;nbsp;AI/ML-enabled molecular design tools, including generative chemistry, predictive ADME/Tox models, property prediction, active learning, virtual screening, and decision-support systems.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Help incorporate AI tools into the DMTA cycle, including compound prioritization, library design, synthetic route ideation, molecular-property prediction, and design hypothesis generation.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Support AI literacy across chemistry and project teams by helping colleagues understand appropriate use, limitations, and interpretation of predictive models.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Help develop workflows that allow medicinal chemists to use modeling and AI tools without requiring deep computational expertise.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Collaboration and Continuous Improvement\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Contribute to the computational chemistry approach for projects and align it with discovery program needs.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Serve as a subject-matter resource for computational chemistry, cheminformatics, AI-enabled design, and molecular modeling.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Support collaborations with CROs, software vendors, academic groups, and computational chemistry consultants where appropriate.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Represent computational chemistry in project team meetings and program discussions.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Maintain awareness of emerging computational, AI, and cheminformatics technologies and recommend adoption where scientifically and operationally justified.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;color: rgb(0, 0, 0); font-size: 10pt;\u0026quot;\u0026gt;PhD in Computational Chemistry, Medicinal Chemistry, Chemical Physics, Biophysics, Cheminformatics, Physical Organic Chemistry, or a related discipline.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A minimum of 3 years of relevant experience in pharma, biotech, or a drug discovery-focused research environment.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Track record of using computational chemistry to impact small-molecule drug discovery programs, ideally through hit-to-lead or lead optimization.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Hands-on expertise in structure-based drug design, ligand-based design, docking, molecular dynamics, virtual screening, QSAR, FEP/free-energy methods, pharmacophore modeling, and multi-parameter optimization.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong working knowledge of medicinal chemistry principles, SAR interpretation, physicochemical property optimization, ADME/PK concepts, and developability considerations.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Practical experience with cheminformatics platforms, chemical databases, chemical data curation, compound registration systems, and project-facing visualization tools.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience with AI/ML applications in molecular design, including predictive modeling, generative chemistry, active learning, or AI-enabled compound prioritization.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong programming or scripting ability, preferably Python, with experience using cheminformatics toolkits such as RDKit and modern data science workflows.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Ability to communicate complex computational concepts clearly to medicinal chemists, biologists, and non-specialist stakeholders.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Ability to collaborate within cross-functional teams and influence project decisions through strong scientific input.\u0026lt;/span\u0026gt;\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Nice to have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience working in a biotech or fast-moving discovery organization\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience implementing user-friendly modeling tools for medicinal chemists\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Familiarity with cloud-based or high-performance computing environments\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience with automated DMTA workflows, electronic lab notebooks, compound management systems, assay-data systems, and integrated discovery platforms\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience supporting discovery across multiple modalities, such as covalent inhibitors, bifunctional molecules, and molecular glues\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Familiarity with synthetic accessibility prediction, retrosynthesis tools, reaction enumeration, and library design\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Scientific contributions through publications, presentations, patents, open-source contributions, or demonstrated project impact\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045440004,"name":"Chemistry Team","child_ids":[],"parent_id":4013330004}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/6130200004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5193475004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":6130200004,"updated_at":"2026-07-29T18:38:14-04:00","requisition_id":"57","title":"Scientist/Sr. Scientist, DMPK","company_name":"General Proximity","first_published":"2026-07-29T17:32:43-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; DMPK expert to help us pioneer this uncharted frontier of drug discovery.\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(206, 212, 217);\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp; \u0026amp;nbsp;\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;Our Story\u0026lt;/span\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;The Position\u0026lt;/span\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking an exceptional DMPK expert to join and lead our drug metabolism and pharmacokinetics function. This is a hands-on, high-impact role in which you will design and execute DMPK studies across our small molecule portfolio, interpret and communicate data to project teams, and serve as a key DMPK contributor in cross-functional settings.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;You will help shape scientific approaches, support regulatory activities, and play an important role in advancing programs from lead optimization through IND. You will work closely with our medicinal chemistry, structural biology, pharmacology, and toxicology teams to translate DMPK science into actionable program decisions.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;The ideal candidate is a hands-on scientist who combines solid technical expertise in ADME, in vivo PK, and PK/PD modeling with the ability to work independently and collaborate effectively across teams. This role is well suited for someone with a few years of DMPK experience at a pharma or biotech who now wants to take on greater ownership and grow at a mission-driven company working at the frontier of induced proximity medicine.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;This role benefits from familiarity with the unique DMPK challenges of induced proximity medicines and bifunctional molecules. These include non-linear and dose-dependent pharmacokinetics arising from ternary complex formation, linker and warhead metabolic soft spots, high molecular weight and physicochemical complexity affecting permeability and oral bioavailability, tissue distribution considerations for proteasome-engaging degraders, and the interpretation of hook-effect phenomena in in vitro and in vivo settings. Exposure to TPD, molecular glue, PROTAC, or other bifunctional modality DMPK is a plus for this role.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;What You\u0026#39;ll Do\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;In Vitro ADME\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Design, execute, and interpret in vitro ADME studies, including metabolic stability, CYP inhibition/induction, plasma protein binding, permeability (Caco-2/MDCK), solubility, and transporter assays.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Contribute to in vitro–in vivo correlation (IVIVC) analyses to inform candidate selection and advance structure–activity/property relationships.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Interpret metabolic soft spot and MetID data, translating findings into actionable guidance for medicinal chemistry teams.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Support CRO relationships for outsourced ADME studies, including scientific oversight of study execution and data quality review.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Bioanalytical Sciences\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Support bioanalytical activities for the portfolio, including CRO-performed LC-MS/MS method development for small molecules and their metabolites across biological matrices.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Help ensure GLP-compliant bioanalytical practices for IND-enabling studies and monitor regulated bioanalysis timelines and data quality through CRO partners.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Contribute to fit-for-purpose bioanalytical approaches for induced proximity molecules, including strategies for quantifying bifunctional compounds and target engagement biomarkers.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;In Vivo Pharmacokinetics\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Design and support in vivo PK studies across rodent and non-rodent species, including study design, data interpretation, and cross-program learnings.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Perform high-quality PK data analysis (NCA and compartmental) using Phoenix WinNonlin or equivalent, ensuring accurate reporting and data integrity.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Integrate PK data with pharmacology and toxicology readouts to inform candidate progression criteria and target product profiles.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Coordinate with CROs for in vivo studies, tracking scope, timelines, and scientific deliverables.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;PK/PD Modeling \u0026amp;amp; Simulation\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Perform PK/PD modeling and simulation, including PBPK modeling (Simcyp, GastroPlus) and allometric scaling to support human PK prediction.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Apply quantitative pharmacology approaches to support translational decision-making, FIH dose selection, and clinical dose range prediction.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Use modeling and simulation to inform go/no-go decisions and communicate DMPK findings to project teams.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Present DMPK modeling results in cross-functional project team meetings.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Regulatory \u0026amp;amp; IND-Enabling Work\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Support DMPK execution for IND-enabling programs, including study design, drafting of study reports, and data package delivery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Contribute to DMPK sections of IND and CTA submissions; author and review relevant study reports and document sections.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Support preparation of DMPK materials for interactions with regulatory agencies, including briefing documents.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Maintain working knowledge of current regulatory guidance (DDI, MIST, bioanalytical method validation, ICH M9/M10) and apply evolving standards.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Collaboration \u0026amp;amp; Cross-Functional Contribution\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Contribute to DMPK team goals and priorities in alignment with company objectives and pipeline evolution.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Serve as an active member of cross-functional project teams, contributing DMPK input to program planning and decision-making.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Support DMPK input for scientific evaluations and collaborations as needed.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Support clinical pharmacology activities as programs advance toward IND, including FIH dose projections, DDI risk assessment, and exposure–response analysis; contribute to clinical pharmacology sections of regulatory documents.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Help track CRO spend and study timelines in alignment with program milestones.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Author and present scientific findings through peer-reviewed publications, conference abstracts, and posters; contribute to General Proximity’s scientific credibility and platform visibility in the induced proximity field.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;PhD in pharmacokinetics, pharmaceutical sciences, or a related discipline.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A minimum of 3 years of industry experience in DMPK, spanning drug discovery and development, with a track record of contributing to small molecule programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Demonstrated ability to work independently and collaborate effectively within cross-functional project teams.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Hands-on expertise in in vitro ADME and in vivo PK, with the ability to translate data into actionable drug discovery insights.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Proficiency in PK data analysis (Phoenix WinNonlin or equivalent) and familiarity with PBPK/PK-PD modeling platforms (Simcyp, GastroPlus, or equivalent).\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience contributing to IND-enabling DMPK studies and authoring study reports.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Working knowledge of FDA, EMA, and ICH guidance relevant to DMPK (DDI, MIST, M9/M10, bioanalytical validation).\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong communication and presentation skills, with the ability to clearly convey DMPK science to cross-functional teams.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Hands-on experience with bioanalytical activities, including LC-MS/MS method development in support of DMPK studies.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Working knowledge of clinical pharmacology principles, including FIH dose projection, DDI risk assessment, and exposure–response analysis, sufficient to support drug development through early clinical stages.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Nice to have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience working in a startup or early-stage biotech environment\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience contributing to a small molecule program advancing toward or through IND\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience with novel modalities such as TPD, molecular glues, or PROTACs\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Familiarity with AI/ML-based ADME prediction tools and an interest in integrating computational approaches (e.g., ML-driven metabolic stability or permeability models, digital twins for PK simulation) into the DMPK workflow alongside established platforms such as Simcyp and GastroPlus\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045440004,"name":"Chemistry Team","child_ids":[],"parent_id":4013330004}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/5980552004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5146575004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":5980552004,"updated_at":"2026-07-29T18:36:25-04:00","requisition_id":"52","title":"Sr. Scientist/Principal Scientist, Medicinal Chemistry","company_name":"General Proximity","first_published":"2026-04-23T18:08:17-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; \u0026lt;span style=\u0026quot;color: rgb(0, 0, 0);\u0026quot;\u0026gt;medicinal chemist\u0026lt;/span\u0026gt;\u0026amp;nbsp;to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking an exceptional medicinal chemist to join our Chemistry and Drug Discovery team. This is a rare opportunity to help build a next-generation drug discovery company from the ground up and contribute directly to the creation of a novel class of therapeutics.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;In this role, you will work at the intersection of chemistry, biology, and platform innovation, partnering closely with cross-functional teams to advance our core discovery capabilities and drive programs from concept through lead optimization. You will play a central role in molecular design of next-generation IPMs, external execution, planning compound screening in routine biophysical or cellular assays and driving data interpretation, and scientific strategy, with the chance to make an outsized impact in a fast-moving startup environment.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are looking for a scientist who combines deep medicinal chemistry expertise with creativity, urgency, and a rigorous builder’s mindset.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;What You’ll Do\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Design and advance medicinal chemistry strategies for next-generation induced proximity medicines, including bifunctional and molecular glue-related modalities.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Lead compound design and SAR campaigns from hit finding and HTS follow-ups through hit-to-lead and lead optimization.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Manage external chemistry CROs, including compound design prioritization, synthetic execution, timelines, and data review.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Direct external DMPK studies and interpret in vitro and in vivo data to guide compound progression.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Partner closely with Biology and Platform teams to design screening strategies and support compound evaluation in biochemical, biophysical, and cellular assays.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Contribute to mechanistic studies that strengthen understanding of lead molecules and inform program direction.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Support intellectual property strategy through invention generation and contributions to patent filings.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Help evaluate and expand opportunities into new disease areas and therapeutic applications.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;PhD in Chemistry, Medicinal Chemistry, or a related field.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A minimum of 5 years of industry experience in small-molecule drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong foundation in medicinal chemistry and its application to disease-focused drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience designing, synthesizing, and optimizing induced proximity medicines, including PROTACs or related approaches.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience across hit finding, hit-to-lead, and lead optimization, including experience building follow-up strategy for HTS, DNA-encoded or phenotypic screening follow-up.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Demonstrated success optimizing compounds for oral exposure and interpreting pharmacokinetic data across multiple species.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Deep understanding of physicochemical properties and in vitro DMPK parameters, including solubility, permeability, metabolic stability, and plasma protein binding, and how to apply them to lead optimization.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience managing external chemistry CROs and driving synthetic programs efficiently.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Excellent written and verbal communication skills.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Nice to have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Experience contributing to programs that advanced from discovery into clinical development\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Background in computational chemistry, molecular modeling, or molecular dynamics\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Familiarity with chemical biology or structural biology techniques, including assay development, compound profiling, pulldown experiments, protein purification, or crystallography\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with HTS or phenotypic screening\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in proteomics, including PTM analysis or chemoproteomic target deconvolution\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045440004,"name":"Chemistry Team","child_ids":[],"parent_id":4013330004}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null}],"meta":{"total":8}}