{"jobs":[{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/5997425004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5155598004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":5997425004,"updated_at":"2026-05-27T13:45:10-04:00","requisition_id":"54","title":"Head of Computational Chemistry","company_name":"General Proximity","first_published":"2026-05-15T18:06:30-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; computational chemist to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are\u0026amp;nbsp;seeking\u0026amp;nbsp;an experienced Head of Computational Chemistry to build and lead our computational chemistry, cheminformatics, and molecular design capabilities. This role will drive small-molecule drug discovery programs by providing strategic and practical\u0026amp;nbsp;modeling\u0026amp;nbsp;support, implementing modern computational workflows, and building the cheminformatics and AI-enabled infrastructure needed to empower medicinal chemists and project teams.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;The successful candidate will be both a scientific leader and a hands-on drug designer: someone who can partner closely with medicinal chemists, structural biologists,\u0026amp;nbsp;biologists,\u0026amp;nbsp;and DMPK scientists to guide compound design from hit identification through lead optimization and candidate\u0026amp;nbsp;selection. They will also\u0026amp;nbsp;deploy practical tools that improve decision-making, accelerate design-make-test-analyze\u0026amp;nbsp;cycles, and make computational and AI-driven methods accessible to bench chemists.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;The ideal candidate is a computational drug hunter who combines deep technical\u0026amp;nbsp;expertise\u0026amp;nbsp;with practical medicinal chemistry judgment. This person should not be an isolated modeler, but a true project partner who sits with chemistry teams, understands the design problem, proposes molecules, helps interpret data, and builds tools that make the broader organization faster and smarter.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;This role is ideal for someone who has worked in a pharma or biotech computational chemistry group and wants to build a modern, AI-enabled computational platform from the ground up while\u0026amp;nbsp;remaining\u0026amp;nbsp;directly involved in molecule design.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;This is an on-site position with flexible working hours.\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;What\u0026amp;nbsp;You’ll\u0026amp;nbsp;Do\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Computational Chemistry and Molecular Design\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Provide hands-on computational chemistry support to small-molecule discovery programs from target evaluation, hit identification, hit-to-lead, and lead optimization through candidate nomination.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Apply structure-based and ligand-based design approaches to guide compound design, including docking, molecular dynamics, pharmacophore\u0026amp;nbsp;modeling, QSAR, scaffold hopping, virtual screening, FEP/free-energy methods, and multi-parameter optimization.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Use structural biology data, including X-ray structures, cryo-EM structures, homology models, and AlphaFold-derived models, to generate actionable design hypotheses.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Partner with\u0026amp;nbsp;the\u0026amp;nbsp;medicinal chemistry team to interpret SAR,\u0026amp;nbsp;optimize\u0026amp;nbsp;potency, selectivity, physicochemical properties, ADME/PK, developability, and synthetic feasibility.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Lead computational design discussions with project teams and translate complex\u0026amp;nbsp;modeling\u0026amp;nbsp;results into clear, practical medicinal chemistry recommendations.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Support portfolio prioritization by evaluating target tractability,\u0026amp;nbsp;ligandability, binding-site quality, chemical matter, and developability risks.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Cheminformatics and Data Infrastructure\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Build and maintain a scalable chem and bioinformatics infrastructure to support compound registration, structure-searching, SAR analysis, property visualization, compound triage, library design, and project decision-making.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Implement tools for chemical data handling, including similarity and substructure searching, R-group analysis, matched molecular pairs, reaction enumeration, compound clustering, property prediction, and visualization.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Work with internal or external engineering and data science teams to integrate chemical, biological, DMPK, structural, and assay data into usable project dashboards and design tools.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Establish best practices for chemical data quality, assay-data curation, compound annotation, metadata standards, and reproducible computational workflows.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Evaluate, implement, and\u0026amp;nbsp;maintain\u0026amp;nbsp;commercial and open-source computational tools, including platforms such as Schrodinger, MOE, CCDC tools,\u0026amp;nbsp;ChemAxon, KNIME, Pipeline Pilot,\u0026amp;nbsp;RDKit,\u0026amp;nbsp;DataWarrior, Spotfire, and related systems.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;AI/ML and Digital Chemistry Tools\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Lead the practical implementation of\u0026amp;nbsp;\u0026lt;u\u0026gt;user-friendly\u0026lt;/u\u0026gt;\u0026amp;nbsp;AI/ML-enabled molecular design tools, including generative chemistry, predictive ADME/Tox models, property prediction, active learning, virtual screening, and decision-support systems.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Identify\u0026amp;nbsp;opportunities to incorporate AI tools into the DMTA cycle, including compound prioritization, library design, synthetic route ideation, molecular-property prediction, and design hypothesis generation.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Promote AI literacy across chemistry and project teams by training scientists on\u0026amp;nbsp;appropriate use, limitations, and interpretation of predictive models.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Build workflows that allow medicinal chemists to use\u0026amp;nbsp;modeling and AI tools without requiring deep computational\u0026amp;nbsp;expertise.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Leadership and Strategy\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Define the computational chemistry strategy for the company and align it with discovery portfolio needs.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Serve as the internal subject-matter expert for computational chemistry, cheminformatics, AI-enabled design, and molecular\u0026amp;nbsp;modeling.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Establish external collaborations with CROs, software vendors, academic groups, AI drug discovery companies, and computational chemistry consultants where\u0026amp;nbsp;appropriate.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Represent computational chemistry in portfolio reviews, program strategy discussions, investor diligence, scientific advisory board meetings, and external collaborations.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Maintain awareness of emerging computational, AI, and cheminformatics technologies and recommend adoption where scientifically and operationally justified.\u0026lt;/span\u0026gt;\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt; color: rgb(0, 0, 0);\u0026quot;\u0026gt;PhD in Computational Chemistry, Medicinal Chemistry, Chemical Physics, Biophysics, Cheminformatics, Physical Organic Chemistry, or a related discipline\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt; color: rgb(0, 0, 0);\u0026quot;\u0026gt;\u0026lt;u\u0026gt;A minimum of 15 years\u0026lt;/u\u0026gt; of relevant experience in pharma, biotech, or a drug discovery-focused research environment\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt; color: rgb(0, 0, 0);\u0026quot;\u0026gt;Demonstrated track record of using computational chemistry to impact small-molecule drug discovery programs, ideally through lead optimization, candidate selection, IND-enabling studies, or clinical development\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt; color: rgb(0, 0, 0);\u0026quot;\u0026gt;Deep expertise in structure-based drug design, ligand-based design, docking, molecular dynamics, virtual screening, QSAR, FEP/free-energy methods, pharmacophore modeling, and multi-parameter optimization\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt; color: rgb(0, 0, 0);\u0026quot;\u0026gt;Strong working knowledge of medicinal chemistry principles, SAR interpretation, physicochemical property optimization, ADME/PK concepts, and developability considerations\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt; color: rgb(0, 0, 0);\u0026quot;\u0026gt;Practical experience with cheminformatics platforms, chemical databases, chemical data curation, compound registration systems, and project-facing visualization tools\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt; color: rgb(0, 0, 0);\u0026quot;\u0026gt;Experience with AI/ML applications in molecular design, including predictive modeling, generative chemistry, active learning, or AI-enabled compound prioritization\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt; color: rgb(0, 0, 0);\u0026quot;\u0026gt;Strong programming or scripting ability, preferably Python, with experience using cheminformatics toolkits such as RDKit and modern data science workflows\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt; color: rgb(0, 0, 0);\u0026quot;\u0026gt;Ability to communicate complex computational concepts clearly to medicinal chemists, biologists, executives, and non-specialist stakeholders\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt; color: rgb(0, 0, 0);\u0026quot;\u0026gt;Demonstrated ability to lead cross-functional teams, mentor scientists, and influence project strategy without relying solely on formal authority\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Nice to have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience building computational chemistry or cheminformatics capabilities in a biotech or fast-moving discovery organization\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience implementing user-friendly modeling tools for medicinal chemists\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Familiarity with cloud-based or high-performance computing environments\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience with automated DMTA workflows, electronic lab notebooks, compound management systems, assay-data systems, and integrated discovery platforms\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience supporting discovery across multiple modalities, such as covalent inhibitors, molecular glues, degraders, etc.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Familiarity with synthetic accessibility prediction, retrosynthesis tools, reaction enumeration, and library design\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong external scientific reputation through publications, presentations, patents, open-source contributions, or demonstrated project impact\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045440004,"name":"Chemistry Team","child_ids":[],"parent_id":4013330004}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/5997363004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5155561004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":5997363004,"updated_at":"2026-05-27T13:43:25-04:00","requisition_id":"53","title":"Head of DMPK","company_name":"General Proximity","first_published":"2026-05-15T17:26:27-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt;\u0026amp;nbsp;\u0026lt;span style=\u0026quot;color: rgb(0, 0, 0);\u0026quot;\u0026gt;DMPK\u0026lt;/span\u0026gt; expert to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking an experienced Head of DMPK to lead and shape our drug metabolism and pharmacokinetics function. This is a high-impact leadership role in which you will own the DMPK strategy across our small molecule portfolio, build and mentor a growing team, and serve as the primary DMPK voice in cross-functional and external settings.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;You will set scientific direction, drive regulatory strategy, and play a pivotal role in advancing programs from lead optimization through IND and into clinical development. You will work closely with our medicinal chemistry, structural biology, pharmacology, and toxicology teams to translate DMPK science into actionable program decisions.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;The ideal candidate is a hands-on scientific leader who combines deep technical expertise in ADME, in vivo PK, and PK/PD modeling with the ability to build and inspire a high-performing team. This role is ideal for someone who has led DMPK at a pharma or biotech and now wants to build the function from the ground up at a mission-driven company working at the frontier of induced proximity medicine.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Critically, this role demands familiarity with the unique DMPK challenges of induced proximity medicines and bifunctional molecules. These include non-linear and dose-dependent pharmacokinetics arising from ternary complex formation, linker and warhead metabolic soft spots, high molecular weight and physicochemical complexity affecting permeability and oral bioavailability, tissue distribution considerations for proteasome-engaging degraders, and the interpretation of hook-effect phenomena in in vitro and in vivo settings. Experience in TPD, molecular glue, PROTAC, or other bifunctional modality DMPK is a meaningful differentiator for this role.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;This is an on-site position with flexible working hours.\u0026lt;/span\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;h1\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;What You’ll Do\u0026lt;/span\u0026gt;\u0026lt;/h1\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;In Vitro ADME\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Provide strategic oversight of in vitro ADME activities including metabolic stability, CYP inhibition/induction, plasma protein binding, permeability (Caco-2/MDCK), solubility, and transporter assays.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Define and champion in vitro–in vivo correlation (IVIVC) strategies across programs to inform candidate selection and advance structure–activity/property relationships.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Lead interpretation of metabolic soft spot and MetID data, integrating findings into actionable guidance for medicinal chemistry teams.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Establish and manage CRO partnerships for outsourced ADME studies, including vendor qualification, scientific oversight, and data quality assurance.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Bioanalytical Sciences\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Own or oversee bioanalytical strategy for the portfolio, including LC-MS/MS method development and validation for small molecules and their metabolites across biological matrices.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Ensure GLP-compliant bioanalytical practices for IND-enabling studies; manage regulated bioanalysis timelines and data quality through CRO partners.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Evaluate and deploy fit-for-purpose bioanalytical approaches for induced proximity molecules, including strategies for quantifying bifunctional compounds and target engagement biomarkers.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;In Vivo Pharmacokinetics\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Oversee and provide strategic direction for in vivo PK studies across rodent and non-rodent species, including study design, data interpretation, and cross-program learnings.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Ensure high-quality PK data analysis (NCA and compartmental) using Phoenix WinNonlin or equivalent, setting standards for reporting and data integrity.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Integrate PK data with pharmacology and toxicology readouts at a program level to shape candidate progression criteria and target product profiles.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Manage and develop CRO relationships for in vivo studies, negotiating scope, timelines, and scientific deliverables.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;PK/PD Modeling \u0026amp;amp; Simulation\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Lead PK/PD modeling and simulation strategy across the portfolio, including PBPK modeling (Simcyp, GastroPlus) and allometric scaling for robust human PK prediction.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Drive quantitative pharmacology frameworks to support translational decision-making, FIH dose selection, and clinical dose range prediction.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Champion the use of modeling and simulation internally to influence go/no-go decisions and communicate DMPK risk to leadership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Represent DMPK modeling expertise in cross-functional project teams, governance reviews, and external partnerships.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Regulatory \u0026amp;amp; IND-Enabling Work\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Own DMPK strategy and execution for IND-enabling programs, including study design, authoring of regulatory documents, and end-to-end data package delivery.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Lead DMPK contributions to IND, CTA, and NDA/BLA submissions; serve as primary author and internal reviewer for relevant sections.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Represent the company in interactions with FDA, EMA, and other regulatory agencies on DMPK matters, including briefing documents and agency meetings.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Maintain expert-level knowledge of current regulatory guidance (DDI, MIST, bioanalytical method validation, ICH M9/M10) and proactively apply evolving standards.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Leadership \u0026amp;amp; Team Building\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Define and execute the long-term DMPK organizational strategy in alignment with company goals and pipeline evolution.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Serve as a key member of the R\u0026amp;amp;D leadership team, contributing to portfolio prioritization, resourcing decisions, and cross-functional planning.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Represent DMPK in business development evaluations, partnering activities, and due diligence assessments.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Support clinical pharmacology activities as programs advance through IND into Phase 1 and beyond, including FIH dose projections, DDI clinical risk assessment, and exposure–response analysis; serve as the primary DMPK liaison to clinical teams and contribute to clinical pharmacology sections of regulatory documents and eventual product labeling.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Own the DMPK functional budget, including CRO spend planning, vendor contract negotiations, and resource forecasting in alignment with program milestones and company-wide R\u0026amp;amp;D priorities.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Author and present scientific findings externally through peer-reviewed publications, conference abstracts, and posters; contribute to General Proximity’s scientific credibility and platform visibility in the induced proximity field.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;PhD in Pharmacokinetics, Pharmaceutical sciences, or a related discipline\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;text-decoration: underline;\u0026quot;\u0026gt;A minimum of 10 years of industry experience in DMPK\u0026lt;/span\u0026gt;, preferably in large pharma, spanning drug discovery and development, with a track record of advancing small molecule programs\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Demonstrated leadership experience, including managing scientists, building teams, and influencing cross-functional strategy\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Deep expertise in in vitro ADME and in vivo PK, with the ability to translate data into actionable drug discovery insights at a program level\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Expert-level proficiency in PK data analysis (Phoenix WinNonlin or equivalent) and PBPK/PK-PD modeling platforms (Simcyp, GastroPlus, or equivalent)\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Proven track record of leading IND-enabling DMPK programs and authoring regulatory submissions\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Extensive experience with FDA, EMA, and ICH guidance relevant to DMPK (DDI, MIST, M9/M10, bioanalytical validation)\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Exceptional communication and presentation skills, with the ability to distill complex DMPK science for diverse audiences including senior leadership and investors\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Demonstrated oversight of regulated bioanalytical activities, including LC-MS/MS method development and validation and GLP bioanalysis in support of IND-enabling programs\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Working knowledge of clinical pharmacology principles, including FIH dose projection, DDI risk assessment, and exposure–response analysis, sufficient to support drug development through early clinical stages\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Nice to have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience building a DMPK function from the ground up at a startup or early-stage biotech\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Track record of advancing at least one small molecule program through IND and into Phase 1/2 clinical trials\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Prior experience in business development, due diligence, or partnering activities involving DMPK assessment\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Familiarity with AI/ML-based ADME prediction tools and an interest in integrating computational approaches (e.g., ML-driven metabolic stability or permeability models, digital twins for PK simulation) into the DMPK workflow alongside established platforms such as Simcyp and GastroPlus\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045440004,"name":"Chemistry Team","child_ids":[],"parent_id":4013330004}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/5807853004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5053946004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":5807853004,"updated_at":"2026-06-04T16:25:15-04:00","requisition_id":"51","title":"Lab Technician/Operations Manager","company_name":"General Proximity","first_published":"2026-02-18T18:18:34-05:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; Lab Technician / Operations Manager to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking an experienced Laboratory Technician / Operations Manager to support our Biology and Platform teams. In this position, you will work at the intersection of lab operations, infrastructure management, and research and development. \u0026lt;span data-contrast=\u0026quot;auto\u0026quot;\u0026gt;This job requires strong skills and\u0026amp;nbsp;demonstra\u0026lt;/span\u0026gt;ble\u0026amp;nbsp;experience in \u0026lt;strong\u0026gt;\u0026lt;span data-contrast=\u0026quot;auto\u0026quot;\u0026gt;all\u0026lt;/span\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;span data-contrast=\u0026quot;auto\u0026quot;\u0026gt; \u0026lt;/span\u0026gt;\u0026lt;strong\u0026gt;three\u0026lt;/strong\u0026gt; \u0026lt;strong\u0026gt;areas\u0026lt;/strong\u0026gt;: lab operations, management, and cell/molecular biology.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Your responsibilities will include 1) general lab management\u0026amp;nbsp;and technician\u0026amp;nbsp;duties: maintaining lab stocks, inventories and ordering, \u0026lt;span data-contrast=\u0026quot;auto\u0026quot;\u0026gt;registering and preparing compounds stocks,\u0026lt;/span\u0026gt;\u0026lt;span data-contrast=\u0026quot;auto\u0026quot;\u0026gt;\u0026amp;nbsp;preparing buffers/media\u0026lt;/span\u0026gt;\u0026lt;span data-contrast=\u0026quot;auto\u0026quot;\u0026gt;, and receiving supplies; 2) operations: organizational and operational tasks, procurement, and equipment acquisition; and 3) biological research: assisting teams with maintaining cell lines and performing cell-based assays\u0026lt;/span\u0026gt;\u0026lt;span data-contrast=\u0026quot;auto\u0026quot;\u0026gt;. You will either train or coordinate the training of new members on the different assays we use in our company.\u0026lt;/span\u0026gt;\u0026lt;span data-ccp-props=\u0026quot;{}\u0026quot;\u0026gt;\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;color: rgb(0, 0, 0); font-size: 10pt;\u0026quot;\u0026gt;BS\u0026amp;nbsp;in Biology or related life sciences field,\u0026amp;nbsp;with a minimum of\u0026amp;nbsp;2\u0026amp;nbsp;years\u0026amp;nbsp;of experience\u0026amp;nbsp;in\u0026amp;nbsp;maintaining\u0026amp;nbsp;laboratory operations for a group of 10+ scientists.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Excellent attention to detail, exceptional organizational and problem-solving skills, top-notch written and interpersonal communication skills.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Proactive mindset towards identifying and solving potential issues to ensure seamless operations.\u0026lt;span data-ccp-props=\u0026quot;{}\u0026quot;\u0026gt;\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience managing sample inventories, vendors, EHS compliance, and lab safety.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Proficiency in:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Mammalian cell culture and passaging/seeding cells\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Cell-based assays\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Registration of inventory and compound stock preparation\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience with HTS and phenotypic assay development\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Plasmid design/cloning and PCR\u0026lt;/span\u0026gt;\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Nice to have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Working knowledge of LIMS/database systems is highly desirable\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Transient/stable protein expression and characterization, immunoprecipitation assays\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience with flow cytometry/cell sorting\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Any computational or programming skills would also be a bonus\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045438004,"name":"Operations","child_ids":[],"parent_id":null}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/5332718004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4817237004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":5332718004,"updated_at":"2025-12-17T16:41:30-05:00","requisition_id":"39","title":"Other Positions","company_name":"General Proximity","first_published":"2024-09-17T16:52:45-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Other Position(s)\u0026lt;br\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Interested in working with us but don\u0026#39;t see a position that fits? Send us your resume/CV by applying here, and we will add you to our talent pool and reach out once we find a good fit!\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; scientists to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://prox.bio/benefits\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/5199733004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4708848004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":5199733004,"updated_at":"2026-01-23T12:46:59-05:00","requisition_id":"36","title":"Principal Scientist, Cancer Biology","company_name":"General Proximity","first_published":"2024-06-07T18:34:19-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; cancer biologist to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span data-contrast=\u0026quot;auto\u0026quot;\u0026gt;We are seeking an experienced cancer biologist to help lead our Biology Team. 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data-aria-posinset=\u0026quot;5\u0026quot; data-aria-level=\u0026quot;1\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Managing a team of exceptional scientists and research associates\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-leveltext=\u0026quot;\u0026quot; data-font=\u0026quot;Symbol\u0026quot; data-listid=\u0026quot;1\u0026quot; data-list-defn-props=\u0026quot;{\u0026amp;quot;335552541\u0026amp;quot;:1,\u0026amp;quot;335559683\u0026amp;quot;:0,\u0026amp;quot;335559684\u0026amp;quot;:-2,\u0026amp;quot;335559685\u0026amp;quot;:720,\u0026amp;quot;335559991\u0026amp;quot;:360,\u0026amp;quot;469769226\u0026amp;quot;:\u0026amp;quot;Symbol\u0026amp;quot;,\u0026amp;quot;469769242\u0026amp;quot;:[8226],\u0026amp;quot;469777803\u0026amp;quot;:\u0026amp;quot;left\u0026amp;quot;,\u0026amp;quot;469777804\u0026amp;quot;:\u0026amp;quot;\u0026amp;quot;,\u0026amp;quot;469777815\u0026amp;quot;:\u0026amp;quot;hybridMultilevel\u0026amp;quot;}\u0026quot; data-aria-posinset=\u0026quot;5\u0026quot; data-aria-level=\u0026quot;1\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Target/indication selection\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-leveltext=\u0026quot;\u0026quot; data-font=\u0026quot;Symbol\u0026quot; data-listid=\u0026quot;1\u0026quot; data-list-defn-props=\u0026quot;{\u0026amp;quot;335552541\u0026amp;quot;:1,\u0026amp;quot;335559683\u0026amp;quot;:0,\u0026amp;quot;335559684\u0026amp;quot;:-2,\u0026amp;quot;335559685\u0026amp;quot;:720,\u0026amp;quot;335559991\u0026amp;quot;:360,\u0026amp;quot;469769226\u0026amp;quot;:\u0026amp;quot;Symbol\u0026amp;quot;,\u0026amp;quot;469769242\u0026amp;quot;:[8226],\u0026amp;quot;469777803\u0026amp;quot;:\u0026amp;quot;left\u0026amp;quot;,\u0026amp;quot;469777804\u0026amp;quot;:\u0026amp;quot;\u0026amp;quot;,\u0026amp;quot;469777815\u0026amp;quot;:\u0026amp;quot;hybridMultilevel\u0026amp;quot;}\u0026quot; data-aria-posinset=\u0026quot;5\u0026quot; data-aria-level=\u0026quot;1\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Animal models of cancer (GEMM, orthotopic, xenograft models), \u0026lt;em\u0026gt;in vivo\u0026lt;/em\u0026gt; study design, and PK/PD interpretation\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-leveltext=\u0026quot;\u0026quot; data-font=\u0026quot;Symbol\u0026quot; data-listid=\u0026quot;1\u0026quot; data-list-defn-props=\u0026quot;{\u0026amp;quot;335552541\u0026amp;quot;:1,\u0026amp;quot;335559683\u0026amp;quot;:0,\u0026amp;quot;335559684\u0026amp;quot;:-2,\u0026amp;quot;335559685\u0026amp;quot;:720,\u0026amp;quot;335559991\u0026amp;quot;:360,\u0026amp;quot;469769226\u0026amp;quot;:\u0026amp;quot;Symbol\u0026amp;quot;,\u0026amp;quot;469769242\u0026amp;quot;:[8226],\u0026amp;quot;469777803\u0026amp;quot;:\u0026amp;quot;left\u0026amp;quot;,\u0026amp;quot;469777804\u0026amp;quot;:\u0026amp;quot;\u0026amp;quot;,\u0026amp;quot;469777815\u0026amp;quot;:\u0026amp;quot;hybridMultilevel\u0026amp;quot;}\u0026quot; data-aria-posinset=\u0026quot;5\u0026quot; data-aria-level=\u0026quot;1\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Managing CROs for \u0026lt;em\u0026gt;in vitro\u0026lt;/em\u0026gt; and \u0026lt;em\u0026gt;\u0026lt;span data-contrast=\u0026quot;auto\u0026quot;\u0026gt;in vivo\u0026lt;/span\u0026gt;\u0026lt;/em\u0026gt;\u0026lt;span data-contrast=\u0026quot;auto\u0026quot;\u0026gt; studies\u0026lt;/span\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-leveltext=\u0026quot;\u0026quot; data-font=\u0026quot;Symbol\u0026quot; data-listid=\u0026quot;1\u0026quot; data-list-defn-props=\u0026quot;{\u0026amp;quot;335552541\u0026amp;quot;:1,\u0026amp;quot;335559683\u0026amp;quot;:0,\u0026amp;quot;335559684\u0026amp;quot;:-2,\u0026amp;quot;335559685\u0026amp;quot;:720,\u0026amp;quot;335559991\u0026amp;quot;:360,\u0026amp;quot;469769226\u0026amp;quot;:\u0026amp;quot;Symbol\u0026amp;quot;,\u0026amp;quot;469769242\u0026amp;quot;:[8226],\u0026amp;quot;469777803\u0026amp;quot;:\u0026amp;quot;left\u0026amp;quot;,\u0026amp;quot;469777804\u0026amp;quot;:\u0026amp;quot;\u0026amp;quot;,\u0026amp;quot;469777815\u0026amp;quot;:\u0026amp;quot;hybridMultilevel\u0026amp;quot;}\u0026quot; data-aria-posinset=\u0026quot;5\u0026quot; data-aria-level=\u0026quot;1\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot; data-ccp-props=\u0026quot;{\u0026amp;quot;201341983\u0026amp;quot;:0,\u0026amp;quot;335559739\u0026amp;quot;:160,\u0026amp;quot;335559740\u0026amp;quot;:279}\u0026quot;\u0026gt;Grant writing\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-leveltext=\u0026quot;\u0026quot; data-font=\u0026quot;Symbol\u0026quot; data-listid=\u0026quot;1\u0026quot; data-list-defn-props=\u0026quot;{\u0026amp;quot;335552541\u0026amp;quot;:1,\u0026amp;quot;335559683\u0026amp;quot;:0,\u0026amp;quot;335559684\u0026amp;quot;:-2,\u0026amp;quot;335559685\u0026amp;quot;:720,\u0026amp;quot;335559991\u0026amp;quot;:360,\u0026amp;quot;469769226\u0026amp;quot;:\u0026amp;quot;Symbol\u0026amp;quot;,\u0026amp;quot;469769242\u0026amp;quot;:[8226],\u0026amp;quot;469777803\u0026amp;quot;:\u0026amp;quot;left\u0026amp;quot;,\u0026amp;quot;469777804\u0026amp;quot;:\u0026amp;quot;\u0026amp;quot;,\u0026amp;quot;469777815\u0026amp;quot;:\u0026amp;quot;hybridMultilevel\u0026amp;quot;}\u0026quot; data-aria-posinset=\u0026quot;6\u0026quot; data-aria-level=\u0026quot;1\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;span data-contrast=\u0026quot;auto\u0026quot;\u0026gt;Nice to have:\u0026lt;/span\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience navigating IND-enabling studies and working on teams that have successfully advanced research to the clinic\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience working at the interface of cancer biology and chemistry \u0026lt;span data-ccp-props=\u0026quot;{\u0026amp;quot;134233117\u0026amp;quot;:false,\u0026amp;quot;134233118\u0026amp;quot;:false,\u0026amp;quot;201341983\u0026amp;quot;:0,\u0026amp;quot;335551550\u0026amp;quot;:0,\u0026amp;quot;335551620\u0026amp;quot;:0,\u0026amp;quot;335559738\u0026amp;quot;:0,\u0026amp;quot;335559739\u0026amp;quot;:0,\u0026amp;quot;335559740\u0026amp;quot;:279}\u0026quot;\u0026gt;\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-leveltext=\u0026quot;\u0026quot; data-font=\u0026quot;Symbol\u0026quot; data-listid=\u0026quot;1\u0026quot; data-list-defn-props=\u0026quot;{\u0026amp;quot;335552541\u0026amp;quot;:1,\u0026amp;quot;335559683\u0026amp;quot;:0,\u0026amp;quot;335559684\u0026amp;quot;:-2,\u0026amp;quot;335559685\u0026amp;quot;:720,\u0026amp;quot;335559991\u0026amp;quot;:360,\u0026amp;quot;469769226\u0026amp;quot;:\u0026amp;quot;Symbol\u0026amp;quot;,\u0026amp;quot;469769242\u0026amp;quot;:[8226],\u0026amp;quot;469777803\u0026amp;quot;:\u0026amp;quot;left\u0026amp;quot;,\u0026amp;quot;469777804\u0026amp;quot;:\u0026amp;quot;\u0026amp;quot;,\u0026amp;quot;469777815\u0026amp;quot;:\u0026amp;quot;hybridMultilevel\u0026amp;quot;}\u0026quot; data-aria-posinset=\u0026quot;6\u0026quot; data-aria-level=\u0026quot;1\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Familiarity or experience with PROTAC/next-gen IPM technologies\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-leveltext=\u0026quot;\u0026quot; data-font=\u0026quot;Symbol\u0026quot; data-listid=\u0026quot;1\u0026quot; data-list-defn-props=\u0026quot;{\u0026amp;quot;335552541\u0026amp;quot;:1,\u0026amp;quot;335559683\u0026amp;quot;:0,\u0026amp;quot;335559684\u0026amp;quot;:-2,\u0026amp;quot;335559685\u0026amp;quot;:720,\u0026amp;quot;335559991\u0026amp;quot;:360,\u0026amp;quot;469769226\u0026amp;quot;:\u0026amp;quot;Symbol\u0026amp;quot;,\u0026amp;quot;469769242\u0026amp;quot;:[8226],\u0026amp;quot;469777803\u0026amp;quot;:\u0026amp;quot;left\u0026amp;quot;,\u0026amp;quot;469777804\u0026amp;quot;:\u0026amp;quot;\u0026amp;quot;,\u0026amp;quot;469777815\u0026amp;quot;:\u0026amp;quot;hybridMultilevel\u0026amp;quot;}\u0026quot; data-aria-posinset=\u0026quot;6\u0026quot; data-aria-level=\u0026quot;1\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience with PPI techniques (e.g., BRET, APEX/BioID, AlphaScreen etc.)\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://prox.bio/benefits\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045441004,"name":"Biology Team","child_ids":[4045442004,4045443004],"parent_id":4013330004}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/5660523004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4985228004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":5660523004,"updated_at":"2025-12-17T16:45:33-05:00","requisition_id":"49","title":"Research Associate, Drug Discovery","company_name":"General Proximity","first_published":"2025-09-26T17:42:08-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; \u0026lt;span style=\u0026quot;color: rgb(0, 0, 0);\u0026quot;\u0026gt;research associate\u0026lt;/span\u0026gt;\u0026amp;nbsp;to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking an experienced\u0026lt;span style=\u0026quot;color: rgb(0, 0, 0);\u0026quot;\u0026gt; Research Associate to be a key member of our Platform/Drug Discovery Team. In this position, you will work in close conjunction with our Biology Team in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.\u0026lt;/span\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;color: rgb(0, 0, 0); font-size: 10pt;\u0026quot;\u0026gt;Your responsibilities will include: designing and executing experiments independently or in collaboration with senior researchers, contributing to the development and optimization of experimental protocols and assays, preparation and handling of biological samples including mammalian cell cultures, performing advanced laboratory techniques and methodologies, data analysis and interpretation under the guidance of senior researchers, and recording and organizing experimental data accurately and efficiently.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;BS or MS in Biology, Biochemistry, Molecular Biology, or a related field.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Industry experience is desirable, but the ability to work hard and learn fast is more important to us.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Deep understanding of small-molecule drug discovery and its relationship to human disease.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top-notch written and oral communication skills.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong data-stringify-type=\u0026quot;bold\u0026quot;\u0026gt;Proficiency in:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul class=\u0026quot;p-rich_text_list p-rich_text_list__bullet\u0026quot; data-stringify-type=\u0026quot;unordered-list\u0026quot; data-indent=\u0026quot;0\u0026quot; data-border=\u0026quot;0\u0026quot;\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-stringify-indent=\u0026quot;0\u0026quot; data-stringify-border=\u0026quot;0\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Mammalian cell culture, passaging/seeding cells, aseptic technique\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-stringify-indent=\u0026quot;0\u0026quot; data-stringify-border=\u0026quot;0\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Molecular biology/cloning, PCR, and other common biology techniques like western blotting, flow cytometry, microscopy, and biochemical assays\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-stringify-indent=\u0026quot;0\u0026quot; data-stringify-border=\u0026quot;0\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Assay development and optimization\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-stringify-indent=\u0026quot;0\u0026quot; data-stringify-border=\u0026quot;0\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong understanding of basic biological principles and laboratory techniques\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-stringify-indent=\u0026quot;0\u0026quot; data-stringify-border=\u0026quot;0\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong problem-solving skills and the ability to work independently as well as part of a team\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong data-stringify-type=\u0026quot;bold\u0026quot;\u0026gt;\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;strong data-stringify-type=\u0026quot;bold\u0026quot;\u0026gt;Nice To Have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-stringify-indent=\u0026quot;0\u0026quot; data-stringify-border=\u0026quot;0\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;2+ years of post-degree experience\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-stringify-indent=\u0026quot;0\u0026quot; data-stringify-border=\u0026quot;0\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience with HTS and phenotypic cell-based assay development\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-stringify-indent=\u0026quot;0\u0026quot; data-stringify-border=\u0026quot;0\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Transient/stable protein expression and purification, immunoprecipitation assays\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-stringify-indent=\u0026quot;0\u0026quot; data-stringify-border=\u0026quot;0\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience working with CRISPR-Cas systems\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-stringify-indent=\u0026quot;0\u0026quot; data-stringify-border=\u0026quot;0\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Familiarity with data analysis software (e.g., Prism) and statistical tools\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-stringify-indent=\u0026quot;0\u0026quot; data-stringify-border=\u0026quot;0\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Familiarity with automatic, robotic dispensers, liquid handlers\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot; data-stringify-indent=\u0026quot;0\u0026quot; data-stringify-border=\u0026quot;0\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Prior experience on teams that have successfully advanced research to the clinic\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045439004,"name":"Platform Team","child_ids":[],"parent_id":4013330004}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/5980552004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5146575004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":5980552004,"updated_at":"2026-05-15T07:00:40-04:00","requisition_id":"52","title":"Scientist II/Senior Scientist, Medicinal Chemistry","company_name":"General Proximity","first_published":"2026-04-23T18:08:17-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; \u0026lt;span style=\u0026quot;color: rgb(0, 0, 0);\u0026quot;\u0026gt;medicinal chemist\u0026lt;/span\u0026gt;\u0026amp;nbsp;to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking an\u0026amp;nbsp;exceptional medicinal chemist to join our Chemistry and Drug Discovery team. This is a rare opportunity to help build a next-generation drug discovery company from the ground up and contribute directly to the creation of a novel class of therapeutics.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;In this role, you will work at the intersection of chemistry, biology, and platform innovation, partnering closely with cross-functional teams to advance our core discovery capabilities and drive programs from concept through lead optimization. You will play a central role in molecular design of next generation IPMs, external execution, planning compound screening in routine biophysical or cellular assays and driving data interpretation, and scientific strategy, with the chance to make an outsized impact in a fast-moving startup environment.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are looking for a scientist who combines deep medicinal chemistry expertise with creativity, urgency, and a rigorous builder’s mindset.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;What You’ll Do\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Design and advance medicinal chemistry strategies for next-generation induced proximity medicines, including PROTACs and related modalities\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Lead compound design and SAR campaigns from hit finding through hit-to-lead and lead optimization\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Manage external chemistry CROs, including compound design prioritization, synthetic execution, timelines, and data review\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Direct external DMPK studies and interpret in vitro and in vivo data to guide compound progression\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Partner closely with Biology and Platform teams to design screening strategies and support compound evaluation in biochemical, biophysical, and cellular assays\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Contribute to mechanistic studies that strengthen understanding of lead molecules and inform program direction\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Support intellectual property strategy through invention generation and contributions to patent filings\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Help evaluate and expand opportunities into new disease areas and therapeutic applications\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;PhD in Chemistry, Medicinal Chemistry, or a related field\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A minimum of 3+ years of industry experience in small-molecule drug discovery\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong foundation in medicinal chemistry and its application to disease-focused drug discovery\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience designing, synthesizing, and optimizing induced proximity medicines, including PROTACs or related approaches\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience across hit finding, hit-to-lead, and lead optimization\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Demonstrated success optimizing compounds for oral exposure and interpreting pharmacokinetic data across multiple species\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Deep understanding of physicochemical properties and in vitro DMPK parameters, including solubility, permeability, metabolic stability, and plasma protein binding, and how to apply them to lead optimization\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience managing external chemistry CROs and driving synthetic programs efficiently\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Nice to have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Experience contributing to programs that advanced from discovery into clinical development\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Background in computational chemistry, molecular modeling, or molecular dynamics\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Familiarity with chemical biology or structural biology techniques, including assay development, compound profiling, pulldown experiments, protein purification, or crystallography\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with HTS or phenotypic screening\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in proteomics, including PTM analysis or chemoproteomic target deconvolution\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;Why Join Us\u0026lt;/span\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Core-team opportunity with meaningful scientific ownership and visibility\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;The chance to help shape a new therapeutic modality and discovery platform\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Close collaboration with a highly ambitious, interdisciplinary team\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A dynamic startup environment where strong ideas and decisive execution matter\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;The opportunity to make a direct impact on the future direction of the company and its pipeline\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045440004,"name":"Chemistry Team","child_ids":[],"parent_id":4013330004}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/6009199004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5160212004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":6009199004,"updated_at":"2026-05-29T15:27:15-04:00","requisition_id":"55","title":"Scientist, Mechanistic Biology","company_name":"General Proximity","first_published":"2026-05-29T15:20:56-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; mechanistic\u0026lt;span style=\u0026quot;color: rgb(0, 0, 0);\u0026quot;\u0026gt; biologist\u0026amp;nbsp;\u0026lt;/span\u0026gt;to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking an experienced mechanistic biologist to join our Discovery Biology Team. In this position, you will work closely with our Platform and Chemistry Teams to drive mechanistic understanding of our lead compounds and support core drug discovery efforts. This is an opportunity to help elucidate novel pharmacological mechanisms of our next-gen IPMs.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Your responsibilities will include designing and executing mechanistic studies on hit compounds, dissecting signaling pathways to map compound mechanism of action, interrogating protein-protein interactions, preparing and analyzing NGS libraries, and developing and deploying functional cell-based assays to characterize novel pharmacology.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;BS, MS or PhD in Cell Biology, Biochemistry, or related field.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Candidates without a PhD should have 5-7+ years of relevant industry experience.\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Previous experience elucidating novel biology underlying small-molecule mechanism of action in a drug discovery context.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top-notch written and oral communication skills.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong experience with\u0026lt;/strong\u0026gt;:\u0026lt;/span\u0026gt;\u0026lt;br\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Cellular and molecular biology, including extensive experience with mammalian cell line work and associated assays, stable cell line generation (lentiviral and CRISPR-based systems), co-IP/pull-down assays, RNA-seq, global proteomics, flow cytometry, plasmid design/cloning, etc.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Small molecule drug development campaigns (hit discovery, hit validation, dose-response studies, SAR and MOA studies)\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Mechanistic studies of cell signaling, pathway analysis, and PTM analysis\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Protein-protein interaction techniques (e.g., BRET, APEX/BioID, AlphaScreen, etc.)\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;NGS library prep, sequencing, and analysis\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Nice to have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience with PROTAC/next-gen IPM technologies\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience working at the interface of mechanistic biology and chemistry\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience working on teams that have successfully advanced research to the clinic\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience managing CROs\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045442004,"name":"Discovery Biology","child_ids":[],"parent_id":4045441004}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/6009487004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":5160352004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":6009487004,"updated_at":"2026-05-29T18:22:03-04:00","requisition_id":"56","title":"Scientist, Medicinal Chemistry","company_name":"General Proximity","first_published":"2026-05-29T18:15:44-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt;\u0026amp;nbsp;\u0026lt;span style=\u0026quot;color: #e03e2d;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;color: rgb(0, 0, 0);\u0026quot;\u0026gt;medicinal chemist\u0026lt;/span\u0026gt; \u0026lt;/span\u0026gt;to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a medicinal chemist to be a member of our Chemistry/Drug Discovery Team. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Your responsibilities will include designing and optimizing first-in-class bifunctional molecules, assessing SAR to inform iterative medicinal chemistry optimization, supervising synthetic efforts with CRO partners, performing and analyzing in cellulo assays, collaborating with our Drug Discovery and IP teams on patent applications, and contributing mechanistic insight on lead drug molecules.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;PhD in Medicinal Chemistry, Chemical Biology, Pharmacology, or related field.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Industry experience is desirable, but the ability to work hard and learn fast is more important to us.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Deep understanding of small-molecule drug discovery and its relationship to human disease.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Able to work fluently at the interface of chemistry and biology.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top-notch written and oral communication skills.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong experience in:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Design, synthesis, and optimization of induced proximity medicines (e.g. PROTACs or other IPMs)\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Hit-to-lead and lead optimization campaigns\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Multi-step organic synthesis, with a proven ability to design and execute complex synthetic routes toward drug-like small molecules\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Medicinal chemistry optimization: SAR, PK/PD, and strong working knowledge of DMPK principles\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Chemical biology techniques including mammalian cell culture, cell-based assays (e.g., cytotoxicity, transfections, stable cell line generation, co-IP), and PPI assays (e.g., BRET, APEX/BioID, AlphaScreen); computational chemistry experience also welcomed\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Nice to have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;HTS and phenotypic assay development\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc.\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Computational or molecular dynamics drug discovery experience\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;DEL experience\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience managing synthetic chemistry CRO teams\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Prior experience on teams that have successfully advanced research to the clinic\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045440004,"name":"Chemistry Team","child_ids":[],"parent_id":4013330004}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}]},{"absolute_url":"https://job-boards.greenhouse.io/generalproximity/jobs/5660301004","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4985104004,"location":{"name":"San Francisco, CA"},"metadata":null,"id":5660301004,"updated_at":"2026-05-19T15:16:46-04:00","requisition_id":"48","title":"Scientist/Sr. Scientist, Chemical Biology","company_name":"General Proximity","first_published":"2025-09-26T15:27:14-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;tl;dr\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking a \u0026lt;a href=\u0026quot;https://www.youtube.com/watch?v=Uyzqmn8Azuo\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;first-rate\u0026lt;/a\u0026gt; \u0026lt;span style=\u0026quot;color: rgb(0, 0, 0);\u0026quot;\u0026gt;chemical biologist\u0026lt;/span\u0026gt;\u0026amp;nbsp;to help us pioneer this uncharted frontier of drug discovery.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Our Story\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or \u0026quot;undruggable\u0026quot; targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.230\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;[1]\u0026lt;/a\u0026gt;, but there are many other possible perturbation types whose potential remains unrealized.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[\u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd3410\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;2\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.213\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;3\u0026lt;/a\u0026gt;, \u0026lt;a href=\u0026quot;https://www.nature.com/articles/nrd.2016.211\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;4\u0026lt;/a\u0026gt;], and our technology holds the same promise.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;The Position\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;We are seeking an \u0026lt;strong\u0026gt;experienced chemical biologist with medicinal chemistry training to be a founding member of our Chemistry/Drug Discovery Team\u0026lt;/strong\u0026gt;. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Your responsibilities will include: supervising synthetic efforts with our CROs, designing, performing, and analyzing \u0026lt;em\u0026gt;in cellulo\u0026lt;/em\u0026gt; assays, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, providing input for mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About You\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;High Agency.\u0026lt;/strong\u0026gt; Initiative, independence, and self-accountability are some of our most valued traits.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Enthusiastic.\u0026lt;/strong\u0026gt; We love people who are excited about what they are doing and are generally attempting to build a high-energy team.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Intensity and Grit.\u0026lt;/strong\u0026gt; Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Prosocial.\u0026lt;/strong\u0026gt; We are here to create life-saving medicines for the patients who need it most. You should be, too.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Qualifications \u0026amp;amp; Nice-To-Haves\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;PhD in Chemical Biology, Medicinal Chemistry, Pharmacology, or related field.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt; font-weight: bold;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Chemical Biology with Medicinal Chemistry experience required.\u0026lt;/span\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Industry experience is desirable, but the ability to work hard and learn fast is more important to us.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Deep understanding of small-molecule drug discovery and its relationship to human disease.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Able to work fluently at the interface of chemistry and biology.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top-notch written and oral communication skills.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong experience with:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Designing, synthesizing, and optimizing induced proximity medicines (e.g. PROTACs or other IPMs)\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Contributing to hit-to-lead and lead optimization studies\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Med-chem optimizations: SAR, PK/PD, strong understanding of DMPK\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), and PPI assays (e.g., BRET, APEX/BioID, AlphaScreen)\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Nice to have:\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Proficiency in HTS and phenotypic assay development\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Computational or molecular dynamics drug discovery experience\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;DEL experience\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Experience managing others, especially synthetic chemistry CRO teams\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Prior experience on teams that have successfully advanced research to the clinic\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;a href=\u0026quot;https://www.generalproximity.bio/benefits\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Benefits\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/a\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Top tier medical, dental, and vision coverage + One Medical membership.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;401(k) retirement plans.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Education and health/fitness incentive programs.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.\u0026amp;nbsp;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Reading budget! We will buy you books. 📚\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026amp;nbsp;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;span style=\u0026quot;font-size: 14pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;About Us\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Work Hard/Play Hard.\u0026lt;/strong\u0026gt; We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we\u0026#39;re at work, we\u0026#39;re there to get things done, and when we\u0026#39;re off, we\u0026#39;re really off. 🌴\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Strong Communication.\u0026lt;/strong\u0026gt; We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Writing First.\u0026lt;/strong\u0026gt; We have a \u0026quot;writing-first\u0026quot; culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Growth.\u0026lt;/strong\u0026gt; As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;hr\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;span style=\u0026quot;font-size: 10pt;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;More info at\u0026amp;nbsp;\u0026lt;a href=\u0026quot;https://jobs.generalproximity.bio/\u0026quot;\u0026gt;jobs.generalproximity.bio\u0026lt;/a\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4045440004,"name":"Chemistry Team","child_ids":[],"parent_id":4013330004}],"offices":[{"id":4006216004,"name":"San Francisco, MBC Biolabs","location":"San Francisco, California, United States","child_ids":[],"parent_id":null}]}],"meta":{"total":10}}