{"jobs":[{"absolute_url":"https://job-boards.greenhouse.io/citytherapeutics/jobs/5240191008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4484318008,"location":{"name":"Remote"},"metadata":null,"id":5240191008,"updated_at":"2026-11-02T15:27:55-05:00","requisition_id":"12","title":"Associate Director, Clinical Pharmacology ","company_name":"City Therapeutics","first_published":"2026-06-03T10:38:12-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p style=\u0026quot;text-align: center;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Associate Director, Clinical Pharmacology\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;City Therapeutics is advancing a next-generation platform for RNAi medicines designed to unlock the full therapeutic potential of gene silencing. By combining innovative delivery technologies with deep expertise in RNA biology, we are building a pipeline of transformative medicines for patients with serious diseases. We are seeking a highly motivated and scientifically rigorous Clinical Pharmacology Scientist to join our dynamic and growing Translational Sciences Team to help shape the clinical development strategy of our growing portfolio.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Associate Director of Clinical Pharmacology will play a critical role in the design, execution, analysis, and interpretation of clinical pharmacology strategies across City Therapeutics\u0026#39; development programs. This individual will report to the Head of Clinical Pharmacology and Pharmacokinetics (CPPK), and provide scientific leadership for pharmacokinetic (PK), pharmacodynamic (PD), exposure-response, and dose selection activities from first-in-human studies through late-stage clinical development.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The successful candidate will work in a highly cross-functional environment, partnering closely with Clinical Development, Regulatory Affairs, Clinical Operations, Biostatistics, Data Science, CMC and external collaborators to drive data-driven decision making and advance clinical development.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Lead development and execution of clinical pharmacology strategies for RNAi therapeutic clinical programs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead and execute model-informed drug development (MIDD) activities, including population PK, exposure-response, PBPK, and mechanistic PK/PD modeling, either independently or in collaboration with quantitative scientists, to support regulatory interactions and development planning.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Contribute to clinical protocol design, statistical analysis plans, clinical study reports, and investigator brochures.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Author and review clinical pharmacology sections of regulatory documents including INDs, briefing packages, meeting requests, and marketing applications.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Participate in interactions with health authorities and contribute to regulatory strategy discussions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop dose selection and dose optimization strategies to support clinical development and regulatory submissions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Integrate nonclinical, translational, biomarker, PK/PD, and clinical data to inform clinical development decisions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Review emerging clinical data and communicate pharmacology insights to project teams and senior leadership.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ensure clinical pharmacology plans align with current regulatory expectations and industry best practices.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;PhD, PharmD, MD, or equivalent advanced degree in Clinical Pharmacology, Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Biomedical Engineering, or a related discipline.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;7+ years of relevant industry experience in clinical pharmacology or pharmacometrics.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated experience supporting early and/or late-stage clinical development programs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience leading clinical pharmacology activities across multiple development programs and regulatory interactions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Hands-on experience with population PK modeling and exposure-response analyses for dose recommendation and optimization.\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience working with external CROs and pharmacometric vendors.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Knowledge of regulatory expectations related to clinical pharmacology and model-informed drug development.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience contributing to CTA, IND, NDA, BLA, or equivalent regulatory submissions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent scientific communication and presentation skills.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to influence cross-functional teams in a fast-paced biotechnology environment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Prior participation in FDA, EMA, or other global regulatory agency interactions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Familiar with translational biomarkers and precision medicine approaches.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in oligonucleotide therapeutics, i.e. siRNA, antisense, gene editing, or other nucleic acid-based modalities.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Compensation\u0026lt;/strong\u0026gt;\u0026lt;br\u0026gt;The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package. Pay range is $174,000 to $196,000\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Why You’ll Love Working Here\u0026lt;/strong\u0026gt;\u0026lt;br\u0026gt;At City, you’ll be part of a team that’s as ambitious as it is collaborative. We’re building an organization that is united by our values:\u0026lt;br\u0026gt;• Courage: We seek out the unknown, challenge boldly, and fight for patients.\u0026lt;br\u0026gt;• Innovation: Curiosity drives us to push the boundaries of what’s possible.\u0026lt;br\u0026gt;• Tempo: We move fast and with purpose. Patients can’t wait, and neither will we.\u0026lt;br\u0026gt;• Yes: We collaborate intensely, with candor and optimism, taking ownership and celebrating the journey together.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;If you’re driven by discovery, pace, and purpose—welcome to City.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Our Working Model:\u0026lt;/strong\u0026gt; \u0026lt;strong\u0026gt;In Person, By Design\u0026lt;/strong\u0026gt;\u0026lt;br\u0026gt;At City, we believe that science and culture thrive together, and that happens best in person. Our working model is clear: we work onsite at our Kendall Square offices five days per week.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;This choice reflects our belief that great science and cultures run on connection, fairness, and growth.\u0026lt;br\u0026gt;• Connection: Face time matters. Building an enduring biotech company is about people, science, and strategy. Working side by side sharpens ideas, accelerates feedback, and fuels innovation for patients.\u0026lt;br\u0026gt;• Fairness: One model for all. Every voice counts, and fairness depends on shared experience. We hold ourselves to one standard across all levels and functions.\u0026lt;br\u0026gt;• Growth: Learning moves faster in person. Growth comes from conversation, observation, and mentorship. We believe in developing talent, and that happens best when we’re together.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We also know that life isn’t always predictable. When individual needs arise, we’re flexible and supportive and work together to balance home life with life at City.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We believe diverse teams drive better science. We welcome applicants from all backgrounds and experiences who share our mission to bring transformative RNAi medicines to patients.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;City Therapeutics is an Equal Opportunity and Affirmative Action employer. All qualified applicants will receive consideration without regard to race, color, religion, national origin, gender, gender identity or expression, sexual orientation, age, disability, veteran status, or any other characteristic protected by law.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;br\u0026gt;City Therapeutics is accepting applications from direct candidates only. Agency inquiries or submissions will not be accepted at this time.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4070882008,"name":"Translational Sciences","child_ids":[],"parent_id":null}],"offices":[{"id":4003011008,"name":"City Therapeutics","location":"Cambridge, Massachusetts, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://job-boards.greenhouse.io/citytherapeutics/jobs/5232666008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4480737008,"location":{"name":"Cambridge, Massachusetts, United States"},"metadata":null,"id":5232666008,"updated_at":"2026-09-08T10:44:40-04:00","requisition_id":"9","title":"Associate Director, Toxicology (Nonclinical Safety Evaluation)","company_name":"City Therapeutics","first_published":"2026-05-27T12:59:06-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;City Therapeutics is a biopharmaceutical company harnessing next-generation engineering to improve and expand the reach of RNAi-based medicines. The company is building a pipeline of innovative RNAi therapeutics to make a significant impact for patients across multiple therapeutic areas. Co-founded by pioneering executives and scientists in RNAi, City Therapeutics is based in Cambridge, MA, and has raised $140 million from leading life sciences investors.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;The Role\u0026lt;/strong\u0026gt;\u0026lt;br\u0026gt;We’re seeking an Associate Director, Nonclinical Safety Evaluation (NSE) who will play a pivotal role in overseeing and critically evaluating nonclinical safety studies across City’s RNAi therapeutic programs. This is a highly visible, hands-on role for someone who brings strong scientific judgment, deep toxicology expertise, and a sharp eye for study design, data quality, and interpretation.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;You will be responsible for providing scientific oversight of outsourced nonclinical safety studies, reviewing and interpreting results, and ensuring that findings are placed in the appropriate biological and development context. Working closely with internal teams and external partners, you will help generate high-quality nonclinical safety packages that support sound decision-making and regulatory advancement.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;How You’ll Contribute\u0026lt;/strong\u0026gt;\u0026lt;br\u0026gt;• Oversee non-GLP and GLP nonclinical safety studies across discovery and development-stage programs, with a focus on quality, execution, interpretation, and fit-for-purpose study design.\u0026lt;br\u0026gt;• Serve as the primary scientific reviewer for outsourced nonclinical safety studies, critically evaluating protocols, amendments, reports, and raw or interpreted data to ensure rigor, clarity, and appropriate conclusions.\u0026lt;strong\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/strong\u0026gt;• Provide expert interpretation of toxicology studies, including general toxicology, safety pharmacology, genetic toxicology, and, where applicable, reproductive toxicology and carcinogenicity findings, highlighting key results, risks, trends, and development implications.\u0026lt;br\u0026gt;• Identify data gaps, inconsistencies, or study conduct issues, and work with internal and external teams to resolve them efficiently and scientifically.\u0026lt;br\u0026gt;• Participate actively in cross-functional team meetings to communicate study progress, interpret findings, and provide nonclinical safety input to broader program discussions.\u0026lt;br\u0026gt;• Partner closely with Chemistry, Biology, Translational Sciences, CMC, Regulatory Affairs, Clinical Development, other relevant functions and program teams to contextualize nonclinical safety findings and support next-step recommendations.\u0026lt;br\u0026gt;• Contribute to the planning and monitoring of nonclinical safety studies required to support candidate progression and regulatory submissions.\u0026lt;br\u0026gt;• Support authoring and review of nonclinical summaries, study interpretation sections, and regulatory documents, including materials supporting IND-enabling packages.\u0026lt;br\u0026gt;• Represent Nonclinical Safety Evaluation in cross-functional discussions, clearly communicating study outcomes, risks, and recommendations.\u0026lt;br\u0026gt;• Help maintain high standards for external study oversight, documentation, data review, and reporting practices across the function.\u0026lt;br\u0026gt;• Stay current on evolving toxicology methods, nonclinical safety expectations, and regulatory guidance relevant to RNAi and oligonucleotide therapeutics.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;The Ideal Candidate\u0026lt;/strong\u0026gt;\u0026lt;br\u0026gt;• PhD or DVM, or equivalent advanced degree in Toxicology, Pharmacology, Pathology, Veterinary Sciences, or a related field, with 5+ years, Masters with 7+ or a Bachelors with 10+ of relevant experience in biotech or pharmaceutical drug development, or direct experience as a Study Director at a GLP-qualified CRO.\u0026lt;br\u0026gt;• Strong experience overseeing outsourced nonclinical safety studies and critically reviewing protocols, data, and final reports.\u0026lt;br\u0026gt;• Deep expertise in the interpretation of toxicology data, including general toxicology, genetic toxicology, reproductive toxicology, carcinogenicity, and related nonclinical safety assessments, with sound scientific judgment and attention to detail.\u0026lt;br\u0026gt;• Strong understanding of GLP and non-GLP study conduct, study design, and reporting standards.\u0026lt;br\u0026gt;• Experience contributing to regulatory packages and supporting nonclinical components of development milestones.\u0026lt;br\u0026gt;• Ability to assess study quality, identify issues early, and communicate risks and recommendations clearly to cross-functional stakeholders.\u0026lt;br\u0026gt;• Experience working with CROs and external collaborators to ensure timely, high-quality study execution and reporting.\u0026lt;br\u0026gt;• Previous siRNA therapeutic development experience is a plus.\u0026lt;br\u0026gt;• Prior small molecule development experience is strongly preferred.\u0026lt;br\u0026gt;• DABT certification is a plus.\u0026lt;br\u0026gt;• Strong communication, collaboration, and organizational skills; highly detail-oriented, self-directed, and able to work independently in a fast-paced, mission-driven environment.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Compensation\u0026lt;/strong\u0026gt;\u0026lt;br\u0026gt;The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package. Pay range is $174,000 to $196,000\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Why You’ll Love Working Here\u0026lt;/strong\u0026gt;\u0026lt;br\u0026gt;At City, you’ll be part of a team that’s as ambitious as it is collaborative. We’re building an organization that is united by our values:\u0026lt;br\u0026gt;• Courage: We seek out the unknown, challenge boldly, and fight for patients.\u0026lt;br\u0026gt;• Innovation: Curiosity drives us to push the boundaries of what’s possible.\u0026lt;br\u0026gt;• Tempo: We move fast and with purpose. Patients can’t wait, and neither will we.\u0026lt;br\u0026gt;• Yes: We collaborate intensely, with candor and optimism, taking ownership and celebrating the journey together.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;If you’re driven by discovery, pace, and purpose—welcome to City.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Our Working Model:\u0026lt;/strong\u0026gt; \u0026lt;strong\u0026gt;In Person, By Design\u0026lt;/strong\u0026gt;\u0026lt;br\u0026gt;At City, we believe that science and culture thrive together, and that happens best in person. Our working model is clear: we work onsite at our Kendall Square offices five days per week.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;This choice reflects our belief that great science and cultures run on connection, fairness, and growth.\u0026lt;br\u0026gt;• Connection: Face time matters. Building an enduring biotech company is about people, science, and strategy. Working side by side sharpens ideas, accelerates feedback, and fuels innovation for patients.\u0026lt;br\u0026gt;• Fairness: One model for all. Every voice counts, and fairness depends on shared experience. We hold ourselves to one standard across all levels and functions.\u0026lt;br\u0026gt;• Growth: Learning moves faster in person. Growth comes from conversation, observation, and mentorship. We believe in developing talent, and that happens best when we’re together.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We also know that life isn’t always predictable. When individual needs arise, we’re flexible and supportive and work together to balance home life with life at City.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We believe diverse teams drive better science. We welcome applicants from all backgrounds and experiences who share our mission to bring transformative RNAi medicines to patients.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;City Therapeutics is an Equal Opportunity and Affirmative Action employer. All qualified applicants will receive consideration without regard to race, color, religion, national origin, gender, gender identity or expression, sexual orientation, age, disability, veteran status, or any other characteristic protected by law.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;br\u0026gt;City Therapeutics is accepting applications from direct candidates only. Agency inquiries or submissions will not be accepted at this time.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;","departments":[{"id":4070882008,"name":"Translational Sciences","child_ids":[],"parent_id":null}],"offices":[{"id":4003011008,"name":"City Therapeutics","location":"Cambridge, Massachusetts, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://job-boards.greenhouse.io/citytherapeutics/jobs/4173305008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4076325008,"location":{"name":"Cambridge, Massachusetts"},"metadata":null,"id":4173305008,"updated_at":"2024-10-16T14:46:19-04:00","requisition_id":"3","title":"Join the RNAi revolution!","company_name":"City Therapeutics","first_published":"2024-10-16T14:46:19-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;Thanks for visiting our Careers Page! We\u0026#39;ll be posting new opportunities soon.\u0026amp;nbsp; If you\u0026#39;d like to express your interest, you can submit your resume or CV here.\u0026amp;nbsp;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We appreciate your interest in career opportunities at City Therapeutics!\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;\u0026lt;span data-olk-copy-source=\u0026quot;MessageBody\u0026quot;\u0026gt;City Therapeutics is accepting resumes/CVs from direct applicants only.\u0026amp;nbsp; Recruitment Agency submissions will not be accepted at this time.\u0026lt;/span\u0026gt;\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4025842008,"name":"General Submissions","child_ids":[],"parent_id":null}],"offices":[{"id":4003011008,"name":"City Therapeutics","location":"Cambridge, Massachusetts, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://job-boards.greenhouse.io/citytherapeutics/jobs/5439610008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4555567008,"location":{"name":"Cambridge, Massachusetts, United States"},"metadata":null,"id":5439610008,"updated_at":"2026-09-30T09:12:11-04:00","requisition_id":"22","title":"Senior Director, Clinical Development (Medical Director)","company_name":"City Therapeutics","first_published":"2026-09-30T09:03:22-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Senior Director, Clinical Development (Medical Director)\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;City Therapeutics is a biotechnology company pioneering next-generation RNA interference (RNAi)-based medicines. We are building a diversified pipeline of innovative therapies through advanced RNAi trigger molecule engineering and novel targeting technologies designed to expand the reach of RNAi beyond the liver. We are seeking passionate, collaborative, and courageous individuals to join our team as we work to transform scientific discoveries into meaningful medicines for patients.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Overview\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Senior Director, Clinical Development (Medical Director) will provide medical and scientific leadership for City Therapeutics’ clinical development programs. This individual will play a central role in shaping clinical development strategy and translating innovative RNAi science into well-designed, executable clinical programs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The successful candidate will serve as the medical lead for one or more programs, with responsibility for clinical strategy, protocol development, study execution, data interpretation, and regulatory interactions. This individual will collaborate closely with Clinical Operations, Biometrics, Pharmacology, Toxicology, Regulatory Affairs, Translational Medicine, and other cross-functional partners.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;This is an opportunity for an experienced physician-scientist to have a meaningful impact within a growing biotechnology company and help advance programs from early clinical development through key milestones, and regulatory approvals.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Provide medical and scientific leadership for one or more clinical development programs.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop and execute clinical development plans aligned with overall program and corporate objectives.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead the design and development of clinical development plans, clinical study protocols, including study objectives, endpoints, eligibility criteria, dose-escalation strategies, and safety-monitoring plans.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Serve as the medical monitor for assigned clinical trials and provide ongoing oversight of participant safety, medical data, and emerging benefit-risk profiles.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partner closely with Clinical Operations to support high-quality and timely study execution.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Review and interpret clinical safety, efficacy, pharmacokinetic, pharmacodynamic, and biomarker data.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead or contribute to clinical study reports, investigator brochures, regulatory submissions, informed consent documents, and other clinical and regulatory materials.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Present clinical strategy and program updates to executive leadership, governance committees, investigators, and external partners.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support interactions with global health authorities, including the FDA and other regulatory agencies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Build strong relationships with investigators, key opinion leaders, clinical research organizations, and other external partners.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborate with Biometrics to develop statistical analysis plans and ensure the quality and integrity of clinical data.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Contribute medical expertise to translational, nonclinical, regulatory, and commercial planning.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Identify clinical risks and recommend thoughtful, practical solutions to keep programs moving forward.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Monitor developments in the therapeutic landscape and incorporate relevant scientific, medical, and competitive insights into clinical strategy.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support due diligence, business development, and external collaboration activities, as needed.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Mentor and develop clinical team members and contribute to the continued growth of the Clinical Development function.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Foster a culture that reflects City Therapeutics’ values of Courage, Innovation, Tempo, and Yes.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;MD or equivalent medical degree required.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Board certification or board eligibility in a relevant medical specialty strongly preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;A minimum of \u0026amp;nbsp;6+ years of relevant clinical development experience within the biotechnology or pharmaceutical industry.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience serving as a medical monitor and providing medical leadership for clinical trials.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated experience designing and executing early-stage clinical studies; experience supporting programs through later-stage development is highly desirable.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong understanding of clinical trial design, drug development, Good Clinical Practice, and global regulatory requirements.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience contributing to regulatory submissions and participating in interactions with health authorities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven ability to analyze and communicate complex clinical and scientific information clearly and effectively.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience working within cross-functional development teams and influencing decisions in a collaborative environment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to operate effectively in a fast-paced, growing biotechnology company and balance strategic thinking with hands-on execution.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent leadership, communication, organizational, and relationship-building skills.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in RNA therapeutics, rare diseases, ophthalmology, immunology, neurology, or another relevant therapeutic area is preferred but not required.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Location: \u0026lt;/strong\u0026gt;This position is based in Cambridge, Massachusetts, and requires an onsite presence five days per week.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Equal Opportunity\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;City Therapeutics is an equal opportunity employer. We are committed to building an inclusive workplace and consider qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, age, disability, veteran status, genetic information, or any other characteristic protected by applicable law.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;City Therapeutics is accepting resumes/CVs from direct applicants only.\u0026amp;nbsp; Recruitment Agency inquiries or submissions will not be accepted at this time.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Compensation:\u0026lt;/strong\u0026gt; The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including relevant skills, experience, internal equity, relevant education or training and market dynamics. In addition, this role is eligible for an annual cash bonus and equity compensation. City Therapeutics offers a comprehensive and competitive benefits package including medical, dental, vision, life insurance, health and dependent care FSA accounts, HSA/HRA accounts with company contributions, in addition to a 401(k) with competitive company match.\u0026amp;nbsp; Per Year Salary Range: $255,000 to $290,000\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4058636008,"name":"Clinical Development","child_ids":[],"parent_id":null}],"offices":[{"id":4003011008,"name":"City Therapeutics","location":"Cambridge, Massachusetts, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://job-boards.greenhouse.io/citytherapeutics/jobs/5460391008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4565855008,"location":{"name":"Cambridge, Massachusetts, United States"},"metadata":null,"id":5460391008,"updated_at":"2026-10-30T15:43:16-04:00","requisition_id":"25","title":"Senior Director, Corporate Development","company_name":"City Therapeutics","first_published":"2026-10-21T16:10:11-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Senior Director, Corporate Development\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;City Therapeutics is a biotechnology company developing the next generation of RNA interference (RNAi) therapeutics to deliver meaningful and durable benefits for patients. Founded by pioneers in the RNAi field, City combines advanced RNAi trigger engineering with novel targeting technologies to expand the therapeutic potential of RNAi in and beyond the liver. Through its proprietary pipeline and strategic collaborations, City is working to bring innovative medicines to patients with significant unmet medical needs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;City Therapeutics is seeking a strategic and execution-oriented Senior Director of Corporate Development to help shape the company’s long-term growth strategy. Reporting to the Chief Operating Officer, this individual will lead the identification, evaluation, and execution of strategic opportunities that strengthen City’s platform, advance its pipeline, and create sustainable value.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;This role will work closely with executive leadership to translate corporate priorities into actionable initiatives, including strategic partnerships, licensing transactions, asset or technology acquisitions, and other growth opportunities. The individual will bring strong scientific and financial judgment, transaction experience, and the ability to build alignment across functions.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The ideal candidate combines strategic perspective with hands-on execution and is comfortable moving between market analysis, financial evaluation, external negotiations, and executive-level recommendations in a growing biotechnology company.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Corporate Strategy and Growth Planning: Partner with the COO and executive leadership to develop and execute City’s corporate development strategy.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Evaluate opportunities that complement City’s internal capabilities, expand its platform or pipeline, and support long-term corporate objectives.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Contribute to strategic planning and portfolio discussions by assessing external opportunities alongside internal investment priorities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Monitor industry trends, competitive developments, and relevant transactions to identify opportunities and inform decision-making.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop clear strategic recommendations supported by scientific, commercial, financial, and operational analysis.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Opportunity Identification and Assessment\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Build and maintain relationships with biotechnology and pharmaceutical companies, academic institutions, investors, advisors, and other potential strategic partners.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Identify and prioritize opportunities for licensing, collaborations, asset or technology acquisitions, and other strategic transactions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Assess opportunities for strategic fit, scientific differentiation, development potential, commercial value, and execution feasibility.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Maintain a disciplined opportunity pipeline with clear evaluation criteria, milestones, and recommendations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Coordinate cross-functional diligence across Research, Clinical Development, Regulatory, Finance, Legal, Intellectual Property, and other relevant functions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partner with Finance to develop valuations, financial models, scenario analyses, and assessments of transaction economics.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Evaluate deal structures, investment requirements, risk allocation, and potential returns.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead or support transactions from initial engagement through diligence, negotiation, definitive agreements, and closing.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborate with the COO, Legal, Finance, and other stakeholders to negotiate terms aligned with City’s strategic and financial objectives.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Prepare decision materials and presentations for executive leadership and the Board of Directors, as appropriate.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Manage transaction timelines, advisors, documentation, and internal communication to support efficient execution.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop compelling materials that communicate City’s scientific differentiation and strategic value to prospective partners.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Represent City in external discussions, partnering meetings, and industry forums.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Establish implementation plans for completed transactions, including governance, ownership, milestones, and measures of success.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support integration planning for acquired assets, technologies, or capabilities, as applicable.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partner with internal leaders to monitor strategic and financial outcomes and identify opportunities to expand the value of existing relationships.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Build alignment across functions and guide complex decisions with clear analysis and sound judgment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Establish scalable processes for opportunity assessment, diligence, transaction approval, and execution.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Build and develop corporate development capabilities as the company grows.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Maintain the highest standards of integrity, discretion, and professionalism in handling confidential information.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Bachelor’s degree in life sciences, business, finance, or a related discipline required; MBA, advanced scientific degree, or equivalent relevant experience preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;10 or more years of relevant experience in biotechnology or pharmaceuticals, with significant experience in corporate development, business development, strategic transactions, or related roles.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated track record of executing licensing agreements, strategic collaborations, acquisitions, or other transactions involving therapeutic assets or platform technologies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong understanding of drug discovery and development and the scientific, regulatory, intellectual property, and commercial factors that influence value.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated ability to evaluate complex opportunities and translate scientific and financial information into actionable recommendations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong financial modeling, valuation, and deal-structuring skills.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience leading cross-functional diligence and managing complex negotiations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent communication and presentation skills, including experience engaging executive leadership and senior external stakeholders.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Established relationships within the biotechnology and pharmaceutical industry.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to work independently, manage competing priorities, and drive execution in a fast-paced environment.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Preferred Experience\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Experience with RNAi, oligonucleotide therapeutics, or other innovative therapeutic platforms.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in an emerging biotechnology company with a hands-on operating environment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Background spanning corporate development and investment banking, consulting, investing, or corporate strategy.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience evaluating both platform-level opportunities and individual therapeutic assets.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with transaction implementation, integration planning, or alliance governance.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;table width=\u0026quot;612\u0026quot;\u0026gt;\n\u0026lt;tbody\u0026gt;\n\u0026lt;tr\u0026gt;\n\u0026lt;td width=\u0026quot;612\u0026quot;\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Compensation\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package. Pay range is $250,000 to $285,000.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Our Working Model: In Person, By Design\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;At City, we believe that science and culture thrive together, and that happens best in person. Our working model is clear: we work onsite at our Kendall Square offices five days per week. This choice reflects our belief that great science and cultures run on connection, fairness, and growth.\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Connection: Face time matters. Building an enduring biotech company is about people, science, and strategy. Working side by side sharpens ideas, accelerates feedback, and fuels innovation for patients.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Fairness: One model for all. Every voice counts, and fairness depends on shared experience. We hold ourselves to one standard across all levels and functions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Growth: Learning moves faster in person. Growth comes from conversation, observation, and mentorship. We believe in developing talent, and that happens best when we are together.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;We also know that life is not always predictable. When individual needs arise, we are flexible and supportive and work together to balance home life with life at City.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;We believe diverse teams drive better science. We welcome applicants from all backgrounds and experiences who share our mission to bring transformative RNAi medicines to patients.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;City Therapeutics is an Equal Opportunity and Affirmative Action employer. All qualified applicants will receive consideration without regard to race, color, religion, national origin, gender, gender identity or expression, sexual orientation, age, disability, veteran status, or any other characteristic protected by law.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;/td\u0026gt;\n\u0026lt;/tr\u0026gt;\n\u0026lt;tr\u0026gt;\n\u0026lt;td width=\u0026quot;612\u0026quot;\u0026gt;\u0026amp;nbsp;\u0026lt;/td\u0026gt;\n\u0026lt;/tr\u0026gt;\n\u0026lt;/tbody\u0026gt;\n\u0026lt;/table\u0026gt;","departments":[{"id":4095732008,"name":"Corporate Development","child_ids":[],"parent_id":null}],"offices":[{"id":4003011008,"name":"City Therapeutics","location":"Cambridge, Massachusetts, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://job-boards.greenhouse.io/citytherapeutics/jobs/5467335008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4569498008,"location":{"name":"Cambridge, Massachusetts, United States"},"metadata":null,"id":5467335008,"updated_at":"2026-10-29T15:03:21-04:00","requisition_id":"26","title":"Sr. Clinical Trial Manager","company_name":"City Therapeutics","first_published":"2026-10-29T14:59:54-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p style=\u0026quot;text-align: center;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Sr. Clinical Trial Manager, Clinical Operations\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;At City Tx, we’re building the next generation of siRNA medicines—and a team bold enough to redefine what RNA therapeutics can do. We are pushing science further and translating breakthrough ideas into meaningful medicines for patients.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We’re looking for curiosity, flexibility and a willingness to roll up your sleeves and contribute wherever you can make an impact. We are looking for people who embrace ambitious challenges, move with purpose, collaborate generously, and are excited to help build both breakthrough medicines and an exceptional company. If\u0026amp;nbsp;you’re energized by ambitious science, meaningful problems, and the opportunity to build something from the ground up, we’d love to hear from you.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are seeking a motivated Senior Clinical Trial Manager (Sr. CTM) to lead the cross-functional Clinical Study Team, plan and manage the operational aspects of assigned clinical trials ensuring their successful delivery. In this role, you will serve as the primary point of contact for study leadership, providing strategic direction and operational oversight from endorsement and start-up through execution, close-out, and reporting.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;You will partner closely with internal stakeholders, CROs, Investigators/clinical sites and external vendors to deliver Phase 1 dose-escalation through later-phase global clinical trials on time and within budget, ensuring quality and compliance with ICH-GCP and regulatory requirements.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;This is a full-time onsite opportunity\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities:\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Accountable for planning and managing the operational aspects of clinical trials throughout the trial’s lifecycle (study start-up, execution and maintenance, close-out, and reporting), ensuring that milestones, objectives, and deliverables are aligned with the Clinical Development Plan and program and company goals.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead cross-functional clinical study teams and\u0026amp;nbsp;serve as the primary point of contact for trial-related activities and updates to internal leadership. Ensuring effective contribution, execution and delivery of clinical study as per quality, plan/timelines, budget.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Contribute to clinical trial strategy, including supporting protocol development, country and site selection, vendor identification, risk management, and development of study timelines and budgets.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Review final drafts and approve key study documents such as informed consent forms, study management plans, submission packages, GDPR compliance materials, and annual reports.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Establish and maintain excellent professional relationships with vendors and CROs, ensuring strong performance through oversight plans, performance tracking, and issue escalation and resolution.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Foster strong partnerships with investigators, site staff, external partners and internal stakeholders to support efficient study execution and achievement of enrollment and delivery targets.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Identify and proactively manage study risks with mitigation strategies and appropriate escalation. Ensure compliance with GCP, SOPs, and regulatory requirements across all operational activities. Champion inspection readiness and support audits and regulatory inspections, including CAPA development.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead the study-level budgeting and site contracting process, in partnership with legal and finance teams. Monitor vendor financial performance and review invoices, change orders, and scopes of work to ensure financial accountability.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversee CRO management of the Trial Master File (TMF), ensuring completeness and quality. Ensure timely and accurate registration and updates in clinical trial registries (e.g., ClinicalTrials.gov).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Identify and implement opportunities to improve clinical operations processes and drive efficiency. Contribute to departmental goals and strategic initiatives.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Bachelor\u0026#39;s degree in a life sciences or healthcare-related discipline (advanced degree a plus).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Minimum of 5+ years of experience in clinical trial management within biotech or pharmaceutical industry.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong project management skills with a proactive, solutions-oriented mindset.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent interpersonal, communication, and organizational skills.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven ability to manage vendors and CROs, driving accountability and high-quality deliverables.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Deep knowledge of clinical trial regulations and guidelines (ICH-GCP, FDA, EMA, etc.).\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to work independently and collaboratively in a dynamic, cross-functional team environment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Willingness to travel up to 15%, including international travel.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026lt;em\u0026gt;City Therapeutics is accepting resumes/CVs from direct applicants only.\u0026amp;nbsp; Recruitment Agency inquiries or submissions will not be accepted at this time.\u0026lt;/em\u0026gt;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Compensation:\u0026lt;/strong\u0026gt;\u0026amp;nbsp;The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including relevant skills, experience, internal equity, relevant education or training and market dynamics. In addition, this role is eligible for an annual cash bonus and equity compensation. City Therapeutics offers a comprehensive and competitive benefits package including medical, dental, vision, life insurance, health and dependent care FSA accounts, HSA/HRA accounts with company contributions, in addition to a 401(k) with competitive company match.\u0026amp;nbsp; Per Year Salary Range: $164,000 to $185,000\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;City Therapeutics is an Equal Opportunity and Affirmative Action employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.\u0026amp;nbsp;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4056889008,"name":"Clinical Operations","child_ids":[],"parent_id":null}],"offices":[{"id":4003011008,"name":"City Therapeutics","location":"Cambridge, Massachusetts, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://job-boards.greenhouse.io/citytherapeutics/jobs/5455149008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4563124008,"location":{"name":"Cambridge, MA"},"metadata":null,"id":5455149008,"updated_at":"2026-10-16T10:51:25-04:00","requisition_id":"23","title":"Vice President, Drug Safety and Pharmacovigilance","company_name":"City Therapeutics","first_published":"2026-10-16T10:51:25-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p style=\u0026quot;text-align: center;\u0026quot;\u0026gt;\u0026lt;strong\u0026gt;Vice President, Drug Safety and Pharmacovigilance\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;City Therapeutics is engineering the future of RNAi-based medicine. Founded by pioneers in RNA interference, we combine next-generation trigger molecule engineering with innovative targeting technologies to expand the reach of RNAi beyond the liver. We are building a diversified research and development pipeline with the goal of creating best-in-class medicines that make a meaningful difference for patients.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Reporting directly to the Chief Medical Officer, the Vice President of Drug Safety and Pharmacovigilance will serve as City Therapeutics’ senior physician safety expert and provide strategic leadership across all pharmacovigilance and drug safety activities.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;This executive will be responsible for establishing and leading the company’s global safety strategy, governance, surveillance, reporting, and risk-management capabilities across its clinical-stage portfolio. The Vice President will provide medical oversight of safety data, lead benefit-risk assessments, and ensure that City maintains scalable, compliant, and inspection-ready pharmacovigilance systems.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The successful candidate will work closely with Clinical Development, Clinical Operations, Regulatory Affairs, Biometrics, Quality, Research, and external partners. This role requires exceptional medical judgment, deep safety-science expertise, and the ability to balance strategic leadership with hands-on execution in a growing biotechnology company.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Develop and lead City Therapeutics’ global pharmacovigilance and drug safety strategy in alignment with the company’s clinical development plans and broader corporate objectives.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Serve as the company’s senior medical authority for safety matters, providing clear, evidence-based benefit-risk assessments and recommendations to executive leadership.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead ongoing safety surveillance and signal detection, including signal validation, evaluation, prioritization, communication, and risk mitigation for development-stage assets.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Establish and lead Safety Review Committees and other safety-governance forums at the study, program, and portfolio levels.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversee the preparation, medical review, and approval of aggregate safety reports, including DSURs, PBRERs/PSURs, risk-management plans, and ad hoc safety assessments.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide expert safety input into clinical protocols, informed consent forms, Investigator’s Brochures, Clinical Study Reports, integrated summaries of safety, development plans, and regulatory submissions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead the strategy and preparation of responses to regulatory authority inquiries involving safety matters, including the development of appropriate MedDRA search and analysis strategies.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide pharmacovigilance leadership for regulatory filings, health authority meetings, inspections, due diligence activities, and other critical company initiatives.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Represent Drug Safety and Pharmacovigilance during interactions with the FDA, EMA, MHRA, and other global regulatory authorities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Build and maintain fit-for-purpose pharmacovigilance policies, procedures, templates, analytics, reporting infrastructure, quality controls, and inspection-readiness capabilities.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversee individual case safety report processing, expedited reporting, reconciliation activities, and safety database operations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partner with Clinical Development and Biometrics on safety data review, database adjudication, statistical analysis, and interpretation.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Select, oversee, and manage pharmacovigilance CROs and other external service providers, including performance, quality, contracts, budgets, invoices, and issue resolution.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Establish and monitor key performance indicators and quality metrics to ensure vendor adherence to regulatory requirements, contractual obligations, timelines, and quality standards.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Monitor changes in global pharmacovigilance regulations and industry standards, lead gap assessments, and implement necessary process improvements.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Build and develop the pharmacovigilance organization as the portfolio advances, including workforce planning, talent development, and succession planning.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Foster a culture of scientific rigor, collaboration, accountability, urgency, and commitment to patient safety.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;MD or equivalent medical degree required.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Board certification or relevant postgraduate clinical training is strongly preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;A minimum of 12 years of progressive experience in pharmacovigilance, drug safety, clinical development, or a closely related function within the biotechnology, pharmaceutical, or CRO industry.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Significant leadership experience, including responsibility for pharmacovigilance strategy, teams, governance, and outsourced operations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated experience building or scaling a pharmacovigilance function within a clinical-stage biotechnology or pharmaceutical company.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Deep knowledge of global pharmacovigilance regulations and guidance, including pre- and post-marketing safety requirements in the United States and European Union.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated expertise in safety surveillance, signal management, aggregate reporting, risk management, and benefit-risk assessment.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong experience supporting clinical development programs and regulatory submissions, including integrated safety analyses and responses to health authority inquiries.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven experience leading regulatory authority interactions and supporting successful pharmacovigilance inspections.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience overseeing CROs, pharmacovigilance service providers, safety databases, and other outsourced operations.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Exceptional medical judgment, analytical thinking, scientific writing, and executive communication skills.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated ability to communicate complex safety information clearly and provide well-supported recommendations to senior leaders and cross-functional teams.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to lead effectively in a fast-paced, growing organization while remaining willing to engage directly in critical deliverables.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in a biotechnology or start-up environment is strongly preferred.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with RNA therapeutics or therapeutic areas relevant to City Therapeutics’ pipeline is a plus.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Our Working Model: In Person, By Design\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;At City, we believe that science and culture thrive together, and that happens best in person. Our working model is clear: we work onsite at our Kendall Square offices five days per week. This choice reflects our belief that great science and cultures run on connection, fairness, and growth.\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Connection: Face time matters. Building an enduring biotech company is about people, science, and strategy. Working side by side sharpens ideas, accelerates feedback, and fuels innovation for patients.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Fairness: One model for all. Every voice counts, and fairness depends on shared experience. We hold ourselves to one standard across all levels and functions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Growth: Learning moves faster in person. Growth comes from conversation, observation, and mentorship. We believe in developing talent, and that happens best when we are together.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;We also know that life is not always predictable. When individual needs arise, we are flexible and supportive and work together to balance home life with life at City.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;We believe diverse teams drive better science. We welcome applicants from all backgrounds and experiences who share our mission to bring transformative RNAi medicines to patients.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Compensation \u0026lt;/strong\u0026gt;The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package. Pay range is $385,000-$405,000\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;City Therapeutics is an Equal Opportunity and Affirmative Action employer. All qualified applicants will receive consideration without regard to race, color, religion, national origin, gender, gender identity or expression, sexual orientation, age, disability, veteran status, or any other characteristic protected by law.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;\u0026lt;strong\u0026gt;City Therapeutics is accepting resumes/CVs from direct applicants only.\u0026amp;nbsp; Recruitment Agency submissions will not be accepted at this time.\u0026lt;/strong\u0026gt;\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4058636008,"name":"Clinical Development","child_ids":[],"parent_id":null}],"offices":[{"id":4003011008,"name":"City Therapeutics","location":"Cambridge, Massachusetts, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://job-boards.greenhouse.io/citytherapeutics/jobs/5457539008","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":4564429008,"location":{"name":"Cambridge, MA"},"metadata":null,"id":5457539008,"updated_at":"2026-10-19T16:23:26-04:00","requisition_id":"24","title":"VP, Quality Assurance","company_name":"City Therapeutics","first_published":"2026-10-19T16:23:26-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Vice President, Quality Assurance\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;City Therapeutics is a clinical-stage biopharmaceutical company dedicated to developing transformative therapies for patients with serious unmet medical needs. As we progress our pipeline through critical regulatory and clinical milestones, we are seeking a seasoned VP of Quality Assurance to lead and own our quality assurance strategy and systems across the organization.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Vice President, Quality Assurance will be the senior quality leader at City Therapeutics, responsible for the design, implementation, and continuous improvement of the company\u0026#39;s Quality Management System (QMS) and all quality assurance functions. This individual will ensure that all development, manufacturing, and clinical activities are conducted in full compliance with cGXP regulations, applicable regulatory guidance, and internal standards. As a key member of the leadership team, the VP of QA will embed a culture of quality across the organization and ensure the company is perpetually inspection-ready.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Quality Strategy \u0026amp;amp; Leadership\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Define and lead the enterprise-wide Quality Assurance strategy, ensuring alignment with regulatory requirements, industry best practices and business objectives.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead quality risk management activities, identifying potential risks and implementing mitigation strategies proactively\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Build, develop, and retain a high-performing QA team, establishing clear roles, accountability structures, and career development pathways\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Champion and embed a proactive quality culture across all departments, serving as the organizational authority on quality matters\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Establish and monitor quality KPIs, metrics, and dashboards; report quality status and trends to executive leadership and the Board as appropriate\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;cGXP Compliance\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Provide executive oversight of all cGXP activities, ensuring compliance with FDA, EMA, ICH, and other applicable international regulations (21 CFR Parts 210/211/312/600, ICH Q7, Q9, Q10, E6, and related guidelines)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Own and continuously improve the Quality Management System, including SOPs, change control, deviation and CAPA management, document control, and training programs\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Regulatory Inspections \u0026amp;amp; Agency Interactions\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Drive and maintain a state of continuous inspection readiness across all sites and functions\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborate with Regulatory Affairs to prepare and review quality sections of IND, BLA, NDA, and other regulatory submissions\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Serve as the primary QA lead during FDA, EMA, and other regulatory agency inspections and audits; manage all aspects of inspection response and commitments\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Supplier, CMO \u0026amp;amp; CRO Oversight\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Establish and maintain a robust vendor qualification and audit program for all CDMOs, CMOs, CROs, and critical suppliers\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Negotiate, review, and execute Quality Technical Agreements with all external partners\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Cross-Functional Partnership\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Partner with Clinical Operations, Regulatory Affairs, CMC, R\u0026amp;amp;D, and Supply Chain to integrate quality requirements into every stage of the product lifecycle\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Support due diligence activities and integration planning for partnerships, in-licensing, and M\u0026amp;amp;A transactions as needed\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Qualifications:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Bachelor\u0026#39;s degree in life sciences, pharmacy, chemistry, or a related field; advanced degree (MS, PhD, PharmD) strongly preferred\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;15+ years of progressive Quality Assurance experience in the biopharmaceutical or pharmaceutical industry, with a minimum of 5 years in a senior or executive leadership role\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated experience building and scaling QA functions in a clinical-stage or growth-phase biopharmaceutical company\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Working knowledge of international regulatory frameworks including EMA, ICH, and PMDA requirements\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong leadership presence with the ability to influence cross-functionally, communicate effectively at the executive level, and drive organizational alignment\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven track record leading successful regulatory inspections (FDA, EMA, or equivalent) and managing health authority interactions and responses\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Extensive experience managing CMO, CDMO, and CRO quality relationships and overseeing multi-site QA systems\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Comprehensive, hands-on expertise in GMP and GCP regulations, including FDA 21 CFR Parts 210/211/312/600 and ICH Q7, Q9, Q10, and E6(R2)\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Preferred\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Experience across multiple modalities including biologics, and/or cell and gene therapies\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Prior experience supporting a product through BLA/NDA approval and commercial launch\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Our Working Model: In Person, By Design\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;At City, we believe that science and culture thrive together, and that happens best in person. Our working model is clear: we work onsite at our Kendall Square offices five days per week. This choice reflects our belief that great science and cultures run on connection, fairness, and growth.\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Connection: Face time matters. Building an enduring biotech company is about people, science, and strategy. Working side by side sharpens ideas, accelerates feedback, and fuels innovation for patients.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Fairness: One model for all. Every voice counts, and fairness depends on shared experience. We hold ourselves to one standard across all levels and functions.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Growth: Learning moves faster in person. Growth comes from conversation, observation, and mentorship. We believe in developing talent, and that happens best when we are together.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;We also know that life is not always predictable. When individual needs arise, we are flexible and supportive and work together to balance home life with life at City.\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;We believe diverse teams drive better science. We welcome applicants from all backgrounds and experiences who share our mission to bring transformative RNAi medicines to patients.\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Compensation\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package. Pay range is $340,000 to $360,000\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;City Therapeutics is an Equal Opportunity and Affirmative Action employer. All qualified applicants will receive consideration without regard to race, color, religion, national origin, gender, gender identity or expression, sexual orientation, age, disability, veteran status, or any other characteristic protected by law.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;em\u0026gt;\u0026lt;strong\u0026gt;City Therapeutics is accepting resumes/CVs from direct applicants only.\u0026amp;nbsp; Recruitment Agency submissions will not be accepted at this time.\u0026lt;/strong\u0026gt;\u0026lt;/em\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4038354008,"name":"CMC","child_ids":[],"parent_id":null}],"offices":[{"id":4003011008,"name":"City Therapeutics","location":"Cambridge, Massachusetts, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null}],"meta":{"total":8}}