{"jobs":[{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8784701002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6514323002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8784701002,"updated_at":"2026-09-04T20:57:07-04:00","requisition_id":"796","title":"Associate Director/Director, Contracts and Alliances ","company_name":"Calico ","first_published":"2026-09-04T20:57:07-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Who We Are:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.\u0026amp;nbsp; Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Description:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Calico is seeking an exceptional and experienced individual to provide business and contractual support for Calico’s external collaborations and internal research activities. This role will be responsible for working closely with Calico scientists and external academic and industry collaborators, to lead and negotiate a wide variety of agreements in support of Calico’s research and development programs, with assistance as needed from Calico’s legal and Intellectual Property (IP) counsel.\u0026amp;nbsp; Agreements include, but are not limited to, sponsored research agreements, licenses, CDAs, material transfer agreements, master services agreements, development and manufacturing service agreements, consulting agreements, software agreements and related amendments.\u0026amp;nbsp; Additionally, this role would also support a number of active research collaborations. Within the Business Development group, this individual will expect to collaborate closely with several internal groups, including Senior Leadership, Senior R\u0026amp;amp;D staff, Alliance Management, Finance, CMC and project teams, in support of Calico’s corporate goals.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Draft, negotiate, and finalize a broad spectrum of agreements, including Sponsored Research Agreements (SRAs), CDAs, MTAs, Licenses (data, software, materials), MSAs, CDMO/manufacturing contracts, and consulting agreements\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Serve as a primary business/contracts liaison for active scientific collaborations, ensuring contractual alignment with program milestones and partner commitments\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborate closely with legal/IP counsel to identify risk, protect Calico\u0026#39;s intellectual property, and ensure regulatory and corporate compliance\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Work seamlessly with Senior Leadership, Senior R\u0026amp;amp;D staff, Alliance Management, Finance, CMC, and scientific project teams to streamline internal approval workflows and facilitate contract lifecycle management\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Drive continuous improvement of contract templates and operational workflows to increase efficiency across the BD group\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Requirements:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Bachelor’s Degree required, Ph.D. or JD is a plus\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Applicants must have extensive industry or academic/institutional experience with a minimum of 5 (Associate Director) or 7 (Director) years of experience in contracts negotiation/management or business development roles that require working closely with current and/or prospective partners\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Direct experience negotiating a variety of R\u0026amp;amp;D agreements within a research-focused healthcare or life sciences environment\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Track record of successfully and efficiently establishing and supporting R\u0026amp;amp;D collaborations\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proficiency in IP terms and material transfer dynamics is essential\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Exceptional communication, independent decision-making and analytical skills, proven ability to deliver on and manage multiple fast-moving priorities, as well as building both internal and external relationships with scientific stakeholders\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must be willing to work onsite at least 4 days a week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary range for this role is $215,000 - $260,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.\u0026lt;/p\u0026gt;","departments":[{"id":4019743002,"name":"BUSINESS DEVELOPMENT","child_ids":[],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8527507002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6405949002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8527507002,"updated_at":"2026-08-20T17:52:23-04:00","requisition_id":"783","title":"Associate Director, External Communications","company_name":"Calico ","first_published":"2026-04-28T18:58:47-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h4\u0026gt;\u0026lt;strong\u0026gt;Who We Are:\u0026lt;/strong\u0026gt;\u0026lt;/h4\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Description:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are seeking an experienced Associate Director, External Communications to join our Corporate Communications team. In this key role, you will develop and execute communication plans that increase awareness of Calico’s scientific advancements, clinical milestones, and partnerships.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Reporting to the Senior Director of Corporate Communications, you will play a key role in maintaining a cohesive brand narrative that reinforces Calico’s overarching mission and translating scientific excellence into compelling external presence as we advance our lead programs toward potential commercialization and patient impact. In addition to subject matter expertise, this position will require strong collaboration and project management skills as you will work with a cross-functional team to shape how our development programs are perceived by the global scientific and medical communities, patients, advocacy groups, media, and our employees.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities:\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Drive communication strategies that develop scientific and medical thought leadership, positioning Calico and its leaders as credible voices through publications, congress presence, executive visibility, and media engagement\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Develop compelling, consistent, and effective messaging for corporate communications materials such as press releases, media materials, Q\u0026amp;amp;A, slide decks, talking points, website content, social media, and videos\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partner with cross-functional team members to drive disease awareness and patient advocacy communications across our clinical programs, particularly our current lead indications\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Effectively collaborate with cross-functional teams, external partners, and agencies to ensure high quality and compliant communications that drive clinical trial recruitment and brand awareness across our clinical portfolio\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Serve as a frontline responder for external/media inquiries and manage communications surrounding clinical data readouts, regulatory milestones, and patient/caregiver inquiries\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Work with partners to develop and execute deal communications\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide ad-hoc support across internal communications as needed\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proactively seek out opportunities to maximize the impact of Corporate Communications\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Requirements:\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Bachelor’s degree in Communications, Journalism, or life sciences field is required, advanced degree a plus\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;10+ years of experience in public relations or communications within the biotech or pharmaceutical industry, including product communications (rare disease experience a plus)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Direct experience managing pre-launch communications for a breakthrough or orphan drug therapy is highly preferred\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong scientific understanding of a how a molecule moves through the discovery and development lifecycle\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Exceptional verbal and written communication skills with a proven track record of translating complex science for diverse audiences\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Expert at managing multiple high-stakes projects simultaneously without compromising accuracy or quality\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to bridge high-level strategic planning with meticulous tactical execution\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated agency and urgency in driving projects forward while remaining thoughtful and inclusive of cross-functional partners\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Confidence to influence and align senior stakeholders to support communication objectives\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must be willing to work onsite at least four days a week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary range for this role is $195,000 - $200,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.\u0026lt;/p\u0026gt;\n\u0026lt;h2 id=\u0026quot;ojxVC\u0026quot; class=\u0026quot;wLzlc\u0026quot;\u0026gt;\u0026lt;/h2\u0026gt;","departments":[{"id":4019739002,"name":"GENERAL \u0026 ADMINISTRATIVE","child_ids":[4019744002,4019736002,4140227002,4140228002],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8438184002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6370659002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8438184002,"updated_at":"2026-08-20T17:52:23-04:00","requisition_id":"769","title":"Associate Director, Medical Writing","company_name":"Calico ","first_published":"2026-02-25T14:05:01-05:00","language":"en","application_deadline":null,"content":"\u0026lt;h4\u0026gt;\u0026lt;strong\u0026gt;Who We Are:\u0026lt;/strong\u0026gt;\u0026lt;/h4\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;strong\u0026gt;Position Description:\u0026lt;/strong\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;Calico is seeking an Associate Director, Medical Writing to provide leadership and functional oversight for writing and leading the review/approval process of high quality clinical and regulatory documents, in compliance with applicable guidelines and regulations. The successful candidate should be able to effectively collaborate with cross-functional representatives, collaboration partners, external vendors, and stakeholders while maintaining a positive team environment. This role will function as a strong project manager and technical leader with demonstrated scientific and stakeholder-focused leadership skills.\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Document Leadership and Authoring:\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Provides medical writing leadership for clinical programs\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Acts as a medical writing subject matter expert and collaborates with the Clinical Science team to deliver on clinical documents including clinical study protocols and protocol-related documents (e.g. informed consent forms), clinical study reports, DSURs, Investigator’s Brochures, IND clinical summaries/overviews, and CTD components (e.g. Module 2 summaries)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partners with the regulatory function to ensure timely completion of high-quality regulatory documents including health authority meeting requests, briefing packages, responses to requests for information, and other documents as required for submissions\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;li\u0026gt;Vendor Management: Provides guidance to external writers on prioritization, content and timeline development, and process management to support clinical development and regulatory activities\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Process Improvement:\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Develops medical writing best practices (e.g. standard timelines, clinical document templates, Calico Style Guide)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partners with the Quality Assurance team to develop new and update existing Standard Operating Procedures for Medical Writing processes and all clinical documents to ensure compliance with ICH requirements\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;strong\u0026gt;Position Requirements:\u0026lt;/strong\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Master’s degree in a life science discipline from an accredited college or university; PharmD or PhD preferred\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Minimum of 8+ years of scientific or medical writing experience at a biotech/ pharmaceutical company or clinical research organization setting\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Expert knowledge of standard clinical regulatory document types and associated regulatory requirements (e.g. ICH guidance, FDA, EMA, Health Canada, Asia-Pacific regulations, etc.)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Prior writing experience in Clinical Study Protocols, Clinical Study Reports, DSUR, Investigator’s Brochures, IND clinical summaries/overviews, CTD clinical summaries, and partnering with external investigators to support Investigator Initiated Study Trials\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Expert ability of Microsoft Office Suite, Adobe Acrobat, collaborative review management systems (e.g. SharePoint) and documents management (e.g. Veeva RIM)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in resource planning and management experience of contractors\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent organization skills with a passion for delivering quality results\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Detail-oriented mindset with excellent verbal and written communication skills\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Self-motivated and able to work collaboratively\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to “roll up sleeves” in a start-up environment and a positive can-do attitude\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must be willing to work onsite at least 4 days a week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary range for this role is $230,000 - $240,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.\u0026lt;/p\u0026gt;","departments":[{"id":4019740002,"name":"DEVELOPMENT","child_ids":[],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8721403002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6486311002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8721403002,"updated_at":"2026-08-20T17:52:23-04:00","requisition_id":"794","title":"Director, Accounting","company_name":"Calico ","first_published":"2026-08-17T13:13:13-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h4\u0026gt;\u0026lt;strong\u0026gt;Who We Are:\u0026lt;/strong\u0026gt;\u0026lt;/h4\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Description:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are seeking a highly conscientious, hands-on Director of Accounting / Assistant Controller who combines technical accounting expertise with a practical drive for data automation and timely/accurate reporting. Operating within a collaborative team, you will play a vital role in our core controllership function.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;In addition to being a high-level oversight role, this position requires someone who genuinely enjoys digging into the details and executing daily accounting operations, tracking clinical trial expenses, and building targeted technology enhancements. Reporting directly to the Controller, you will partner closely with cross-functional teams across Calico, including the Finance Team and Clinical Operations.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Core Financial Close:\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Manage and perform significant portions of the monthly, quarterly, and annual accounting close processes, including the preparation and review of journal entries, reconciliations, and management reports\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversee and perform various account accruals, prepaids, and cash disbursements\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Clinical Trial Accruals:\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Lead the end-to-end clinical trial expense accrual process and partner closely with Clinical Operations to track study expenses and ensure high accuracy and transparency in clinical project accounting\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Operational Accounting:\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Perform 1099 and 1042 reporting and sales/use tax accruals and returns\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Compliance \u0026amp;amp; Technical Accounting:\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Ensure strict compliance with US GAAP, corporate accounting policies, and SOX requirements\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Document and maintain effective internal controls\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Liaise with Alphabet Technical Accounting and Accounting groups as needed\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Team Leadership:\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Manage, mentor, and develop accounting staff, fostering a collaborative and high-performing team environment\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Targeted Process Optimization:\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Analyze existing workflows, design and implement smart automation enhancements (such as Excel-to-NetSuite journal pipelines), and identify opportunities to leverage Gemini-enabled AI tools to improve efficiency and accuracy\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Requirements:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Bachelor’s degree in Accounting or Finance; a minor, secondary degree, or heavy coursework in Computer Science, Data Analytics, or a related field is a strong plus\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;CPA required\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;10+ years of progressive accounting experience, including a strong background in public accounting, corporate accounting, or technical accounting\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Extensive, hands-on experience managing complex clinical trial accruals within the life sciences, biotech, or pharmaceutical industry\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;High integrity with the highest standards of professional ethics, financial integrity, and personal accountability\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Attention to detail\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Superior problem-solving skills and strong desire to go the extra mile to find root causes of and solve problems\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to multi-task and balance multiple requests without losing sight of overall objectives and deadlines\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven track record of managing and developing accounting professionals\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Hands-on proficiency with NetSuite; proficiency with Coupa and Adaptive helpful\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong analytical skills and systems thinking\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to optimize accounting workflows, with specific experience in Excel-to-NetSuite journal automation or similar system integrations\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must be willing to work onsite at least 4 days a week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary range for this role is $240,000 - $245,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.\u0026lt;/p\u0026gt;\n\u0026lt;h2 id=\u0026quot;ojxVC\u0026quot; class=\u0026quot;wLzlc\u0026quot;\u0026gt;\u0026lt;/h2\u0026gt;","departments":[{"id":4019739002,"name":"GENERAL \u0026 ADMINISTRATIVE","child_ids":[4019744002,4019736002,4140227002,4140228002],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8602856002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6436019002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8602856002,"updated_at":"2026-08-20T17:52:23-04:00","requisition_id":"790","title":"Director, Regulatory Affairs ","company_name":"Calico ","first_published":"2026-06-22T12:07:20-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Who We Are:\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and\u0026amp;nbsp; exciting place to catalyze and enable medical breakthroughs.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Description\u0026lt;/strong\u0026gt;:\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Calico is seeking a Regulatory Director that will be responsible for, in collaboration with development partners as applicable, developing and implementing innovative regulatory strategies to support development programs, in compliance with health authority guidelines and regulations. The successful candidate should be able to collaborate effectively with cross-functional representatives, collaboration partners, external vendors, and stakeholders, while maintaining a positive team environment.\u0026amp;nbsp;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Responsibilities:\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Accountable to develop and execute the world-wide regulatory strategy for assigned programs (from IND-enabling to clinical proof-of-concept and beyond), which may include programs that are first-in-class, where no or limited FDA guidance exists, that have an external business partner, and where there are multiple indications\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide high-level regulatory counsel to Executive Leadership, Clinical Development, CMC, and Commercial teams regarding clinical trial designs, surrogate endpoints, accelerated approval strategies, and risk mitigation\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead interactions with global health agencies to inform global regulatory/ registration requirements for assigned programs, developing briefing packages for such engagements\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborate with the executive team to define regulatory strategies consistent with Calico’s mission for both internal and partnership programs\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversee or directly enable the compilation, review, and submission of regulatory applications and submissions to agencies, ensuring accuracy, completeness, and timeliness\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborate with CMC, CMC Regulatory, and other stakeholders to develop effective CMC regulatory strategies\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Represent Regulatory Affairs on development teams and support development teams in interpreting and applying regulations and guidance documents\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Offer strategic and regulatory compliance input to protocols, reports, and other source documents\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Stay updated on global regulatory guidance and regulations, communicating key updates to senior leadership and project teams, anticipating changes in the regulatory landscape, and developing proactive strategies accordingly\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborate with cross-functional teams and support functions, including full-time staff and independent consultants, as required\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Other duties as assigned\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Requirements:\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Master’s degree in a life science discipline from an accredited college or university; PhD preferred\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Minimum of 10 years of regulatory affairs experience in an industry, academia, or clinical research organization setting, with experience with rare disease development and/or novel endpoints preferred\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven track record of developing and executing regulatory submissions in the biotechnology sector, including experience with at least one major application and approval, preferred (NDA, BLA, MAA, etc.)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Direct experience authoring and managing (or oversight of others) substantial regulatory submissions (INDs/CTAs required; experience with successful NDA/BLA/MAA filings is highly desirable)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong knowledge of global regulations, including, but not limited to, FDA and EMA\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with mechanisms to expedite agency interactions\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Advanced skill in creating and assessing proposals to regulatory authorities on regulatory paths and clinical plans, guiding development teams with recommendations for changes/refinements based on ongoing regulatory outcomes throughout development, and in leading productive health authority interactions, including well organized preparation of cross functional teams\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent communication skills with the ability to influence stakeholders internally and externally\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Self-motivated, with the ability to work independently or as part of a team\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strategic thinker with strong problem-solving skills\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Exceptional organizational skills with the ability to prioritize tasks in a fast-paced environment\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Self-motivated and able to work collaboratively\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to “roll up sleeves” in a start-up environment and a positive can-do attitude\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must be willing to work onsite at least four days per week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary range for this role is $275,000 - $280,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.\u0026lt;/p\u0026gt;\n\u0026lt;h4\u0026gt;\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;\u0026lt;/h4\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;h2 id=\u0026quot;ojxVC\u0026quot; class=\u0026quot;wLzlc\u0026quot;\u0026gt;\u0026lt;/h2\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4019740002,"name":"DEVELOPMENT","child_ids":[],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8430246002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6367405002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8430246002,"updated_at":"2026-08-20T17:52:23-04:00","requisition_id":"767","title":"Director, Regulatory CMC","company_name":"Calico ","first_published":"2026-02-19T15:01:20-05:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Who We Are:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Description\u0026lt;/strong\u0026gt;:\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Director of Regulatory CMC will lead the development and execution of global CMC regulatory strategies for our pipeline of small molecules and monoclonal antibodies to accelerate clinical development and ensure seamless commercialization. Acting as a key partner to CMC and Quality, this role is responsible for the CMC content of all investigational and marketing applications, ensuring technical consistency and compliance across all stages of the product lifecycle, from early-stage development through commercialization. This role requires a blend of deep scientific fluency, meticulous attention to detail, and the ability to negotiate effectively with global health authorities. The ideal candidate has a deep understanding of the nuanced differences in regulatory pathways for both small molecules and monoclonal antibodies.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Key Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Regulatory Strategy and Agency Interactions\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Design and implement innovative global CMC regulatory strategies to secure approvals and maintain compliance for clinical and commercial products, identifying potential risks and creating robust mitigation plans\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide expert guidance on CMC requirements for both Small Molecules (NCEs) and Biologics (mAbs), including comparability protocols and stability requirements\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Act as the primary CMC point of contact for the FDA, EMA, and other global health authorities\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead preparations for and represent the company in formal regulatory meetings and in generating responses to Health Authority queries\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Assess the impact of manufacturing changes on global registrations and determine the necessary reporting categories globally\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Define the necessary data packages to support post-approval supplements\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Submissions and Document Leadership\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Author or direct the preparation, authoring, and technical review of CMC sections for global filings:\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;-ND/IMPD: Investigational applications for early-phase trials\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;-NDA/BLA/MAA: Marketing applications for US, EU, and other major markets\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Manage the lifecycle of the Common Technical Document (CTD) specifically focusing on Module 3 (Quality) and Module 2.3 (Quality Overall Summary)\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Cross-Functional Partnership\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Collaborate closely with Process Development, Analytical Development, and Quality Assurance to ensure data integrity and filing readiness\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide regulatory risk assessments for various manufacturing scenarios (e.g., changing CDMO sites or scaling up bioreactors)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Monitor and stay current on the evolving CMC regulations (ICH guidelines, FDA/EMA guidance) and translate complex requirements into actionable internal plans\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Requirements:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;B.S./M.S. in a scientific discipline (Chemistry, Biology, or Pharmacy); A Ph.D. or PharmD is highly preferred\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;10+ years of experience in the biopharmaceutical industry, with at least 7 years focused specifically on CMC Regulatory Affairs\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Successful track record of contributing to least one major marketing application (NDA or BLA) from initial drafting through approval\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong understanding of GMP (Good Manufacturing Practices) and ICH guidelines and deep knowledge of small molecule and mAbs modalities\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to interpret complex technical data (e.g., mass spectrometry, impurity profiles, dissolution data) and effectively present it in a clear, regulatory-compliant narrative\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Deep knowledge of FDA, EMA, ICH regulations, and global regulatory requirements\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Exceptional communication and interpersonal skills, with the ability to effectively interact and influence internally with cross-functional stakeholders and senior leadership and externally with CMOs and regulatory authorities\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must be willing to work onsite at least four days per week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary range for this role is $275,000 - $280,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;h2 id=\u0026quot;ojxVC\u0026quot; class=\u0026quot;wLzlc\u0026quot;\u0026gt;\u0026lt;/h2\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4019740002,"name":"DEVELOPMENT","child_ids":[],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8552878002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6416200002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8552878002,"updated_at":"2026-08-20T17:52:23-04:00","requisition_id":"788","title":"Head of Peptide Drug Discovery","company_name":"Calico ","first_published":"2026-05-15T17:48:17-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h4\u0026gt;\u0026lt;strong\u0026gt;Who We Are:\u0026lt;/strong\u0026gt;\u0026lt;/h4\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Description:\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Calico is seeking an accomplished and motivated individual to lead peptide drug discovery efforts as Head of Peptide Drug Discovery within the Calico Drug Discovery organization. This leader will collaborate with innovative and diverse scientists and play a pivotal role in advancing Calico’s Preclinical pipeline to deliver oral peptide drug candidates to our development portfolio. The ideal candidate will leverage deep and proven expertise in the lead optimization of oral peptide drug candidates, provide leadership for discovery and development stage projects, and be an effective people leader capable of attracting key talent and developing our internal team of peptide drug discovery scientists.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities:\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Act as a peptide drug discovery Subject Matter Expert (SME) to deliver peptide Drug Candidates for the Calico pipeline\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Be a strong and collaborative partner with leaders of the Calico Small Molecule Drug Discovery, Machine Learning Platform, Discovery Technologies, Research, CMC, DMPK, Toxicology and Clinical Development functions\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Bridge Computation \u0026amp;amp; Chemistry: Serve as the primary technical liaison and advisor to the ML team, ensuring chemical intuition effectively informs algorithmic design and vice versa\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide leadership, mentorship, and development of the existing peptide chemistry team to achieve a cutting-edge peptide drug discovery group\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Maintain oversight of external CROs to support chemistry, formulation, and DMPK for peptide drug discovery\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Contribute to global regulatory submissions (e.g., IBs, Briefing Books, INDs, NDAs)\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Represent Calico in external scientific collaborations, committees, and consortia in the field of peptide drug discovery\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Requirements:\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;PhD in organic/peptide/medicinal chemistry with 12+ years of drug discovery experience in biotech or pharma\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven track record of successfully delivering peptide drug candidates that have achieved preclinical candidate nomination and progressed into clinical development\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Effective communication with ML-peptide design team to deliver prioritized design concepts through strong collaboration\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong working knowledge of the synthesis of peptide libraries and the scale-up of peptide lead molecules\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong organic chemistry skills to direct the synthesis of non-canonical amino acids\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Deep knowledge in the use of formulation excipients to enhance oral bioavailability of peptide drug candidates\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Self-motivated, enthusiastic, and highly adaptable with the ability to quickly identify project challenges and pivot strategies in a fast-paced environment\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Exceptional oral communication and writing skills, with record-keeping and data organization skills\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must be willing to work onsite 5 days a week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Nice to Have:\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Experience with evaluation of AI/ML generated peptides in Hit Generation-Lead Optimization\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary range for this role is $320,000 - $350,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.\u0026lt;/p\u0026gt;\n\u0026lt;h2 id=\u0026quot;ojxVC\u0026quot; class=\u0026quot;wLzlc\u0026quot;\u0026gt;\u0026lt;/h2\u0026gt;","departments":[{"id":4126314002,"name":"DRUG DISCOVERY","child_ids":[],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8533254002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6407870002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8533254002,"updated_at":"2026-08-20T17:52:23-04:00","requisition_id":"785","title":"Machine Learning Scientist / Senior Machine Learning Scientist","company_name":"Calico ","first_published":"2026-05-01T14:04:56-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h4\u0026gt;\u0026lt;strong\u0026gt;Who We Are:\u0026lt;/strong\u0026gt;\u0026lt;/h4\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Description\u0026lt;/strong\u0026gt;:\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Calico is seeking a machine learning scientist to join a research group investigating how genome sequence determines regulatory function and how dysregulation of these programs drives aging. We develop sequence-based deep learning models that predict gene expression, chromatin accessibility, and other functional readouts directly from DNA. We use these models to interpret human genetic variation, map causal regulatory mechanisms, and identify promising intervention points.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;This work builds on a sustained research program at the intersection of deep learning and regulatory genomics, including:\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;a href=\u0026quot;https://www.nature.com/articles/s41592-021-01252-x\u0026quot;\u0026gt;Avsec, Ž. \u0026lt;em\u0026gt;et al.\u0026lt;/em\u0026gt; Effective gene expression prediction from sequence by integrating long-range interactions. \u0026lt;em\u0026gt;Nat Methods\u0026lt;/em\u0026gt; \u0026lt;strong\u0026gt;18\u0026lt;/strong\u0026gt;, 1196–1203 (2021).\u0026lt;/a\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;a href=\u0026quot;https://www.nature.com/articles/s41592-022-01562-8\u0026quot;\u0026gt;Yuan, H. \u0026amp;amp; Kelley, D. R. scBasset: sequence-based modeling of single-cell ATAC-seq using convolutional neural networks. \u0026lt;em\u0026gt;Nat Methods\u0026lt;/em\u0026gt; \u0026lt;strong\u0026gt;19\u0026lt;/strong\u0026gt;, 1088–1096 (2022).\u0026lt;/a\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;a href=\u0026quot;https://www.nature.com/articles/s41588-024-02053-6\u0026quot;\u0026gt;Linder, J., Srivastava, D., Yuan, H., Agarwal, V. \u0026amp;amp; Kelley, D. R. Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation. Nature Genetics (2025).\u0026lt;/a\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;Additional research can be found \u0026lt;a href=\u0026quot;https://scholar.google.com/citations?hl=en\u0026amp;amp;user=NYzqnv0AAAAJ\u0026amp;amp;view_op=list_works\u0026amp;amp;sortby=pubdate\u0026quot;\u0026gt;here\u0026lt;/a\u0026gt;.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Design and train deep learning models for biological sequence analysis, with emphasis on gene regulation, single-cell genomics, and variant interpretation\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Partner with experimental scientists to connect model predictions to biological mechanisms — designing validation experiments, analyzing large-scale genomics data, and translating computational findings into actionable biological insights\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Communicate research through publications, open-source software, and public-facing tools\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Requirements:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;PhD in computational biology, bioinformatics, computer science, or a related field, and 0-5 years (for Scientist level) or 5+ years (for Senior Scientist level) of additional training in an industry or academic setting, with a strong publication record\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Deep expertise in machine learning with solid grounding in algorithms, data structures, and statistics\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Substantive knowledge of molecular biology and genetics; familiarity with genomic data types and public data resources\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Hands-on experience analyzing genomics sequencing data, ideally including single-cell assays\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Fluency with modern AI-assisted development and research tools (e.g., LLM-based coding assistants, literature synthesis), with a habit of proactively integrating new tools to accelerate scientific workflows\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;A collaborative disposition, strong follow-through, and comfort working at the interface of computation and experiment\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must be willing to work onsite at least four days per week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary range for this role is $170,000 - $240,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses\u0026lt;/p\u0026gt;\n\u0026lt;h2 id=\u0026quot;ojxVC\u0026quot; class=\u0026quot;wLzlc\u0026quot;\u0026gt;\u0026lt;/h2\u0026gt;","departments":[{"id":4019741002,"name":"RESEARCH","child_ids":[],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8202054002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6250798002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8202054002,"updated_at":"2026-08-20T17:52:23-04:00","requisition_id":"715","title":"Medical Director / Senior Medical Director","company_name":"Calico ","first_published":"2025-10-07T16:00:10-04:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Who We Are:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company\u0026amp;nbsp;whose mission is to harness advanced technologies and model systems to increase our\u0026amp;nbsp;understanding of the biology that controls human aging. Calico will use that knowledge to\u0026amp;nbsp;devise interventions that enable people to lead longer and healthier lives. Calico’s highly\u0026amp;nbsp;innovative technology labs, its commitment to curiosity-driven discovery science and, with\u0026amp;nbsp;academic and industry partners, its vibrant drug-development pipeline, together create an\u0026amp;nbsp;inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Description:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Medical Director/Senior Medical Director at Calico will report to the Head of Clinical Sciences and will be responsible for providing strategic input to the translational and clinical development of projects related to Calico’s mission to improve human health span by understanding aging and age-related diseases. This position is focused on neurologic/neuropsychiatric indications.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Leads cross-functional teams which develop the strategy to translate preclinical mechanistic data to humans and to develop translational biomarkers for novel targets in neurological/neuropsychiatric indications\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Actively interfaces with research and drug development leaders, at Calico and outside of Calico, to inform disease indication strategies for novel targets\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Utilizes clinical expertise to guide the development and utilization of preclinical models in close collaboration with discovery and biomarker scientists at Calico and Calico’s business partners\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Works closely with other drug developmental functional areas to shape new clinical programs at multiple points in their evolution, with an emphasis on translational/early clinical development (Phase 0 through Phase 2)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Designs and executes experimental medicine studies to demonstrate proof-of-mechanism of novel targets in neuropsychiatric diseases\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Designs and executes early clinical development plans to demonstrate proof-of-concept in various neuropsychiatric indications\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provides scientific/medical content and other input as appropriate for protocols, Investigator Brochures, Clinical Study reports, regulatory submissions and responses, and other program documents\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Requirements:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Scientifically minded Physician (M.D.) or Physician-Scientist (M.D./Ph.D.)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;At least 5 years of translational, clinical trial, or drug development experience in the biotech/pharmaceutical industry, academia, or equivalent\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Board-certified/eligible in Neurology and/or Pediatric Neurology highly preferred\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Clinical/translational research and/or drug development experience across various neuropsychiatric disease areas\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Medical knowledge in treating patients across various neuropsychiatric or neurological indications\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Working knowledge or direct experience in early clinical trial methodology (Phase 0, Phase 1, Phase 2)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven leadership skills and ability to bring out the best in others on a cross-functional team\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Able to provide effective leadership through influence in a highly matrixed environment, including various drug development functions within Calico and its development partners\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must possess excellent oral and written English communication skills\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must be willing to work onsite at least 4 days a week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary range for this role is $374,000 - $435,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.\u0026lt;/p\u0026gt;","departments":[{"id":4019740002,"name":"DEVELOPMENT","child_ids":[],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8426342002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6365661002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8426342002,"updated_at":"2026-08-20T17:52:23-04:00","requisition_id":"760","title":"Postdoctoral Fellow, Hahn Lab - Brain Aging","company_name":"Calico ","first_published":"2026-02-17T18:51:19-05:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Who We Are\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;The Calico Postdoctoral Fellowship Program\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are seeking ambitious early career scientists to join us in our mission to increase our understanding of the biology that controls human aging. This is a unique opportunity for individuals to distinguish themselves in aging research, deepen scientific training, and develop research independence.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Postdoctoral Fellowship is a fixed-term educational assignment (three years with a potential fourth year extension) with rolling start dates. Postdoctoral Fellows are fully integrated into Calico\u0026#39;s labs and community.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The program is designed to train individuals to become independent investigators in an academic or industry setting upon successful completion of the assignment. Fellows will receive regular feedback and guidance from their mentor(s) and participate in a formal annual review process to review project progress and individual performance and provide career coaching.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Lead Independent Research:\u0026lt;/strong\u0026gt; Focus on their own project(s), which should pursue new research directions with dedicated resources for innovative and potentially high-risk/high-reward research\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Contribute to Calico’s Core Mission:\u0026lt;/strong\u0026gt; Contribute to furthering an understanding of aging and age-related diseases\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Drive Scientific Progress:\u0026lt;/strong\u0026gt; Execute experiments meticulously, analyze data (including computational analysis if applicable) and troubleshoot procedures as needed\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Publish Work:\u0026lt;/strong\u0026gt; Generate work that is expected to be submitted for publication in a timely fashion upon completion of the assignment\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Collaborate and Communicate:\u0026lt;/strong\u0026gt; Actively collaborate across Calico\u0026#39;s diverse teams and scientific community, including presenting progress and results to diverse audiences of computational scientists, lab scientists, and engineers\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Professional Development:\u0026lt;/strong\u0026gt; Engage with a community of other Postdoctoral Fellows and senior leadership through professional and career development opportunities, such as the annual Postdoc Summit, research-in-progress presentations, senior leader lunch sessions, and skill-building workshops\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Requirements\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The successful candidate will demonstrate characteristics valued across Calico\u0026#39;s programs, including being a self-motivated team player, detail-oriented, extremely organized, and comfortable working on complex problems.\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Education:\u0026lt;/strong\u0026gt; Must have recently completed a PhD degree in a relevant scientific or computational field\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Current PhD student applicants should be within 12 months of completing their PhD\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Applicants who have already graduated must have completed their PhD within the past 3 years and not have been employed as a postdoc at more than one other lab/company since graduation\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Experience:\u0026lt;/strong\u0026gt; Must have made important contributions to science in their area, ideally demonstrated by having had a meaningful first author paper accepted for publication\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Technical Versatility (General):\u0026lt;/strong\u0026gt; While specific technical skills are project-dependent, proficiency in core scientific methodologies, analytical skills, and quantitative problem-solving is essential\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Communication:\u0026lt;/strong\u0026gt; Strong teamwork and communication skills are required\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Adaptability:\u0026lt;/strong\u0026gt; Must be flexible and able to respond quickly to shifting priorities, demonstrating a \u0026quot;can-do\u0026quot; attitude\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Onsite Availability: \u0026lt;/strong\u0026gt;Must be willing to work onsite five days per week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Application Requirements\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Postdoctoral Fellowship has four application components:\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Research proposal (a 1-2 page creative and original research proposal on what you’d like to investigate in the Hahn Lab during your fellowship - note that project goals may evolve during the training period)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Updated CV with a full list of publications\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Cover letter\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;List of 2-3 references that we may contact, including your PhD thesis advisor and any postdoctoral advisors (if applicable)\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary for this role is $95,000.\u0026amp;nbsp;More information on our postdoctoral fellowship program can be found\u0026amp;nbsp;\u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://www.calicolabs.com/postdoctoral-fellowship\u0026quot; target=\u0026quot;_blank\u0026quot; data-saferedirecturl=\u0026quot;https://www.google.com/url?q=https://www.calicolabs.com/postdoctoral-fellowship\u0026amp;amp;source=gmail\u0026amp;amp;ust=1771459299809000\u0026amp;amp;usg=AOvVaw1pDUYdwqZ7ji3QVdiX4eqG\u0026quot;\u0026gt;here\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt;.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;About the Hahn Lab\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We investigate why specific cells in the brain, such as the resident immune cells, microglia, are among the earliest and most vulnerable sites of aging, and how this vulnerability contributes to neurodegeneration. Our central mission is to decode and ultimately reprogram the brain’s immune system to dampen or reverse age‑related neuroinflammation.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The group has established a rich arsenal of novel \u0026lt;em\u0026gt;in vitro\u0026lt;/em\u0026gt; and \u0026lt;em\u0026gt;in vivo\u0026lt;/em\u0026gt; discovery platforms. These include \u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://www.biorxiv.org/content/10.1101/2025.09.02.673859v1\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;scalable heterochronic myeloid cell replacement\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt; paradigms that swap native microglia with CRISPR‑ready donor cells across young and old brains, and a new protocol for generating neuroimmune cells \u0026lt;em\u0026gt;in vitro\u0026lt;/em\u0026gt; at a very large scale. These novel approaches are complemented by world-class CNS research equipment including custom FACS instruments, bespoke electrophysiology setups and 2 Photon \u0026lt;em\u0026gt;in vivo\u0026lt;/em\u0026gt; imaging suites. We welcome proposals that aim to decode altered cell-cell signaling in the CNS through scalable \u0026lt;em\u0026gt;in vitro\u0026lt;/em\u0026gt; or \u0026lt;em\u0026gt;ex vivo\u0026lt;/em\u0026gt; experimentation. The ideal candidate is a highly motivated innovator with a strong collaborative streak and a drive to take discoveries from cellular models to whole organisms.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Publications from the group include:\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Full \u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://scholar.google.com/citations?user=vpa2PmUAAAAJ\u0026amp;amp;hl=en\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;Google Scholar\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Gizowski \u0026amp;amp; Popova \u0026lt;em\u0026gt;et al.\u0026lt;/em\u0026gt;, Heterochronic myeloid cell replacement reveals the local brain environment as key driver of microglia aging (2025) \u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://www.biorxiv.org/content/10.1101/2025.09.02.673859v1\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;BioRxiv\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Hahn \u0026lt;em\u0026gt;et al.\u0026lt;/em\u0026gt;, Atlas of the aging mouse brain reveals white matter as vulnerable foci (2023) \u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://www.cell.com/cell/fulltext/S0092-8674(23)00805-X\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;Cell\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Schaum \u0026amp;amp; Lehallier \u0026amp;amp; Hahn \u0026lt;em\u0026gt;et al.\u0026lt;/em\u0026gt;, Ageing hallmarks exhibit organ-specific temporal signatures (2020) \u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://www.nature.com/articles/s41586-020-2499-y\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;Nature\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;h2 id=\u0026quot;ojxVC\u0026quot; class=\u0026quot;wLzlc\u0026quot;\u0026gt;\u0026lt;/h2\u0026gt;","departments":[{"id":4068847002,"name":"POSTDOCTORAL FELLOWSHIPS","child_ids":[],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8426350002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6365665002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8426350002,"updated_at":"2026-08-20T17:52:23-04:00","requisition_id":"761","title":"Postdoctoral Fellow, Jan Lab - Parkinson's Disease","company_name":"Calico ","first_published":"2026-02-17T19:01:07-05:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Who We Are\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;The Calico Postdoctoral Fellowship Program\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are seeking ambitious early career scientists to join us in our mission to increase our understanding of the biology that controls human aging. This is a unique opportunity for individuals to distinguish themselves in aging research, deepen scientific training, and develop research independence.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Postdoctoral Fellowship is a fixed-term educational assignment (three years with a potential fourth year extension) with rolling start dates. Postdoctoral Fellows are fully integrated into Calico\u0026#39;s labs and community.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The program is designed to train individuals to become independent investigators in an academic or industry setting upon successful completion of the assignment. Fellows will receive regular feedback and guidance from their mentor(s) and participate in a formal annual review process to review project progress and individual performance and provide career coaching.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Lead Independent Research:\u0026lt;/strong\u0026gt; Focus on their own project(s), which should pursue new research directions with dedicated resources for innovative and potentially high-risk/high-reward research\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Contribute to Calico’s Core Mission:\u0026lt;/strong\u0026gt; Contribute to furthering an understanding of aging and age-related diseases\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Drive Scientific Progress:\u0026lt;/strong\u0026gt; Execute experiments meticulously, analyze data (including computational analysis if applicable) and troubleshoot procedures as needed\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Publish Work:\u0026lt;/strong\u0026gt; Generate work that is expected to be submitted for publication in a timely fashion upon completion of the assignment\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Collaborate and Communicate:\u0026lt;/strong\u0026gt; Actively collaborate across Calico\u0026#39;s diverse teams and scientific community, including presenting progress and results to diverse audiences of computational scientists, lab scientists, and engineers\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Professional Development:\u0026lt;/strong\u0026gt; Engage with a community of other Postdoctoral Fellows and senior leadership through professional and career development opportunities, such as the annual Postdoc Summit, research-in-progress presentations, senior leader lunch sessions, and skill-building workshops\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Requirements\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The successful candidate will demonstrate characteristics valued across Calico\u0026#39;s programs, including being a self-motivated team player, detail-oriented, extremely organized, and comfortable working on complex problems.\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Education:\u0026lt;/strong\u0026gt; Must have recently completed a PhD degree in a relevant scientific or computational field\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Current PhD student applicants should be within 12 months of completing their PhD\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Applicants who have already graduated must have completed their PhD within the past 3 years and not have been employed as a postdoc at more than one other lab/company since graduation\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Experience:\u0026lt;/strong\u0026gt; Must have made important contributions to science in their area, ideally demonstrated by having had a meaningful first author paper accepted for publication\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Technical Versatility (General):\u0026lt;/strong\u0026gt; While specific technical skills are project-dependent, proficiency in core scientific methodologies, analytical skills, and quantitative problem-solving is essential\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Communication:\u0026lt;/strong\u0026gt; Strong teamwork and communication skills are required\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Adaptability:\u0026lt;/strong\u0026gt; Must be flexible and able to respond quickly to shifting priorities, demonstrating a \u0026quot;can-do\u0026quot; attitude\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Onsite Availability: \u0026lt;/strong\u0026gt;Must be willing to work onsite five days per week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Application Requirements\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Postdoctoral Fellowship has four application components:\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Research proposal (a 1-2 page creative and original research proposal on what you’d like to investigate in the Jan Lab during your fellowship - note that project goals may evolve during the training period)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Updated CV with a full list of publications\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Cover letter\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;List of 2-3 references that we may contact, including your PhD thesis advisor and any postdoctoral advisors (if applicable)\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary for this role is $95,000.\u0026amp;nbsp;More information on our postdoctoral fellowship program can be found\u0026amp;nbsp;\u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://www.calicolabs.com/postdoctoral-fellowship\u0026quot; target=\u0026quot;_blank\u0026quot; data-saferedirecturl=\u0026quot;https://www.google.com/url?q=https://www.calicolabs.com/postdoctoral-fellowship\u0026amp;amp;source=gmail\u0026amp;amp;ust=1771459299809000\u0026amp;amp;usg=AOvVaw1pDUYdwqZ7ji3QVdiX4eqG\u0026quot;\u0026gt;here\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt;.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;About the Jan Lab\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are interested in understanding the causes of Parkinson’s Disease and seek to use this knowledge to identify disease-modifying targets.\u0026amp;nbsp; We collaborate broadly to integrate genetic, genomic and biomarker data from idiopathic PD patients to develop novel hypotheses and to guide the development of cellular and \u0026lt;em\u0026gt;in vivo\u0026lt;/em\u0026gt; models of PD-related cell states in which we can test these hypotheses.\u0026amp;nbsp; We also develop and deploy a variety of functional genomics tools to interrogate these systems using both biochemically-precise phenotypic screens and holistic cell state screens based on representation learning of morphological and transcriptomic data.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are currently welcoming applicants interested in understanding the cellular mechanisms that drive neurodegenerative processes.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Publications from the group include:\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;David Harris \u0026amp;amp; Calvin Jan, CRISPuRe-seq: pooled screening of barcoded ribonucleoprotein reports reveals regulation of RNA polymerase III transcription by the integrated stress response via mTOR (2025) \u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://pubmed.ncbi.nlm.nih.gov/39921565/\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;Nucleic Acids Research\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Meraj Ramezani \u0026lt;em\u0026gt;et al.\u0026lt;/em\u0026gt;, A genome-wide atlas of cell morphology (2025) \u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://www.nature.com/articles/s41592-024-02537-7\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;Nature Methods\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;John Yong el al., Impairment of lipid homeostasis causes accumulation of protein aggregates in the lysosome (2024) \u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://elifesciences.org/articles/86194\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;eLife\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;","departments":[{"id":4068847002,"name":"POSTDOCTORAL FELLOWSHIPS","child_ids":[],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8426406002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6365672002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8426406002,"updated_at":"2026-08-20T17:52:23-04:00","requisition_id":"764","title":"Postdoctoral Fellow, Nile Lab - Ubiquitin/UBL Chemical Biology","company_name":"Calico ","first_published":"2026-02-17T19:27:02-05:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Who We Are\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;The Calico Postdoctoral Fellowship Program\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are seeking ambitious early career scientists to join us in our mission to increase our understanding of the biology that controls human aging. This is a unique opportunity for individuals to distinguish themselves in aging research, deepen scientific training, and develop research independence.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Postdoctoral Fellowship is a fixed-term educational assignment (three years with a potential fourth year extension) with rolling start dates. Postdoctoral Fellows are fully integrated into Calico\u0026#39;s labs and community.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The program is designed to train individuals to become independent investigators in an academic or industry setting upon successful completion of the assignment. Fellows will receive regular feedback and guidance from their mentor(s) and participate in a formal annual review process to review project progress and individual performance and provide career coaching.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Responsibilities\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Lead Independent Research:\u0026lt;/strong\u0026gt; Focus on their own project(s), which should pursue new research directions with dedicated resources for innovative and potentially high-risk/high-reward research\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Contribute to Calico’s Core Mission:\u0026lt;/strong\u0026gt; Contribute to furthering an understanding of aging and age-related diseases\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Drive Scientific Progress:\u0026lt;/strong\u0026gt; Execute experiments meticulously, analyze data (including computational analysis if applicable) and troubleshoot procedures as needed\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Publish Work:\u0026lt;/strong\u0026gt; Generate work that is expected to be submitted for publication in a timely fashion upon completion of the assignment\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Collaborate and Communicate:\u0026lt;/strong\u0026gt; Actively collaborate across Calico\u0026#39;s diverse teams and scientific community, including presenting progress and results to diverse audiences of computational scientists, lab scientists, and engineers\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Professional Development:\u0026lt;/strong\u0026gt; Engage with a community of other Postdoctoral Fellows and senior leadership through professional and career development opportunities, such as the annual Postdoc Summit, research-in-progress presentations, senior leader lunch sessions, and skill-building workshops\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Requirements\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The successful candidate will demonstrate characteristics valued across Calico\u0026#39;s programs, including being a self-motivated team player, detail-oriented, extremely organized, and comfortable working on complex problems.\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Education:\u0026lt;/strong\u0026gt; Must have recently completed a PhD degree in a relevant scientific or computational field\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Current PhD student applicants should be within 12 months of completing their PhD\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Applicants who have already graduated must have completed their PhD within the past 3 years and not have been employed as a postdoc at more than one other lab/company since graduation\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Experience:\u0026lt;/strong\u0026gt; Must have made important contributions to science in their area, ideally demonstrated by having had a meaningful first author paper accepted for publication\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Technical Versatility (General):\u0026lt;/strong\u0026gt; While specific technical skills are project-dependent, proficiency in core scientific methodologies, analytical skills, and quantitative problem-solving is essential\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Communication:\u0026lt;/strong\u0026gt; Strong teamwork and communication skills are required\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Adaptability:\u0026lt;/strong\u0026gt; Must be flexible and able to respond quickly to shifting priorities, demonstrating a \u0026quot;can-do\u0026quot; attitude\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Onsite Availability: \u0026lt;/strong\u0026gt;Must be willing to work onsite five days per week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Application Requirements\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Postdoctoral Fellowship has four application components:\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Research proposal (a 1-2 page creative and original research proposal on what you’d like to investigate in the Nile Lab during your fellowship - note that project goals may evolve during the training period)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Updated CV with a full list of publications\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Cover letter\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;List of 2-3 references that we may contact, including your PhD thesis advisor and any postdoctoral advisors (if applicable)\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary for this role is $95,000.\u0026amp;nbsp;More information on our postdoctoral fellowship program can be found\u0026amp;nbsp;\u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://www.calicolabs.com/postdoctoral-fellowship\u0026quot; target=\u0026quot;_blank\u0026quot; data-saferedirecturl=\u0026quot;https://www.google.com/url?q=https://www.calicolabs.com/postdoctoral-fellowship\u0026amp;amp;source=gmail\u0026amp;amp;ust=1771459299809000\u0026amp;amp;usg=AOvVaw1pDUYdwqZ7ji3QVdiX4eqG\u0026quot;\u0026gt;here\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt;.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;About the Nile Lab\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;The Nile Lab investigates the fundamental mechanisms by which E3 ubiquitin ligases recognize, modify, and regulate substrates. We aim to understand the biochemical and biophysical principles governing ubiquitin/UBL signaling, how E3s achieve specificity, how their activity is modulated, and how these insights can inform systematic strategies to redirect E3-ligase activity through chemical biology.\u0026lt;br\u0026gt;\u0026lt;br\u0026gt;Our research emphasizes rigorous protein biochemistry, including protein purification, quantitative mechanistic studies, and the reconstitution of multi-component systems \u0026lt;em\u0026gt;in vitro\u0026lt;/em\u0026gt;, while connecting these insights back to cellular context. We use a wide range of approaches such as structural biology, chemical biology, directed-evolution/selection technologies, and advanced imaging or biophysical methods. We welcome proposals that address core questions in ubiquitin signaling through rigorous biochemical experimentation and creative approaches. Ideal candidates will be highly quantitative, intellectually fearless, and collaborative team players who thrive in a multidisciplinary environment.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Publications from the group include:\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Full \u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://scholar.google.com/citations?user=6NjgInYAAAAJ\u0026amp;amp;hl=en\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;Google Scholar\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;John Wang \u0026amp;amp; Hannah Baddock \u0026lt;em\u0026gt;et al\u0026lt;/em\u0026gt;., Structure of the p53 degradation complex from HPV16 (2024) \u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://www.nature.com/articles/s41467-024-45920-w\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;Nature Communications\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;em\u0026gt;\u0026amp;nbsp;\u0026lt;/em\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Peiyuan Zhang \u0026amp;amp; Xiyun Ye \u0026lt;em\u0026gt;et al\u0026lt;/em\u0026gt;., Reversibly reactive affinity selection mass spectrometry enables maturation of covalent peptides (2024) \u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://pubs.acs.org/doi/abs/10.1021/jacs.4c05571\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;JACS\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Xiyun Ye \u0026amp;amp; Peiyuan Zhang \u0026lt;em\u0026gt;et al\u0026lt;/em\u0026gt;., Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6. (2023) \u0026lt;span style=\u0026quot;text-decoration: underline; color: rgb(53, 152, 219);\u0026quot;\u0026gt;\u0026lt;a style=\u0026quot;color: rgb(53, 152, 219); text-decoration: underline;\u0026quot; href=\u0026quot;https://pubs.rsc.org/en/content/articlelanding/2023/sc/d3sc02782a\u0026quot; target=\u0026quot;_blank\u0026quot;\u0026gt;Chemical Sciences\u0026lt;/a\u0026gt;\u0026lt;/span\u0026gt;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;","departments":[{"id":4068847002,"name":"POSTDOCTORAL FELLOWSHIPS","child_ids":[],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8822364002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6530964002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8822364002,"updated_at":"2026-09-18T16:36:44-04:00","requisition_id":"797","title":"Principal Scientist, DMPK","company_name":"Calico ","first_published":"2026-09-18T16:36:44-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h4\u0026gt;\u0026lt;strong\u0026gt;Who We Are:\u0026lt;/strong\u0026gt;\u0026lt;/h4\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Description:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Calico is seeking a Principal Scientist, Drug Metabolism and Pharmacokinetics to join our Drug Discovery team. This position is a unique opportunity to shape the DMPK strategy and contribute to the development of innovative therapeutics. This role will function as an individual contributor, collaborating closely with external partners such as Pharma and CROs.\u0026amp;nbsp;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Responsibilities:\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Strategic Leadership\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Develop and implement the DMPK strategy to support drug discovery and development programs\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Provide expert DMPK guidance and input to project teams\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Represent the DMPK function in cross-functional meetings and interactions with external stakeholders\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Stay abreast of the latest advancements in DMPK science and regulatory guidelines\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Collaborate closely with project, biology, and chemistry leads to support and\u0026amp;nbsp; advance programmatic goals\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;Collaboration and Outsourcing\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Effectively collaborate with CROs and other external partners to execute DMPK studies\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Manage CRO relationships, including study design, data analysis, and report writing\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Oversee the quality and timely delivery of DMPK data from external partners\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;Individual Contribution\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Design, coordinate and interpret DMPK studies, including \u0026lt;em\u0026gt;in vitro\u0026lt;/em\u0026gt; and \u0026lt;em\u0026gt;in vivo\u0026lt;/em\u0026gt; experiments\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Analyze and interpret DMPK data to support drug candidate selection and development\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Author and review DMPK reports, regulatory documents, and scientific publications\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Requirements:\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Ph.D. in pharmacokinetics, drug metabolism, or a related field\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;8+ years of experience in DMPK within the pharmaceutical or biotechnology industry\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience as a DMPK functional representative on drug discovery teams\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong understanding of DMPK principles and their application to drug discovery\u0026amp;nbsp; and development\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Extensive experience in designing and conducting \u0026lt;em\u0026gt;in vitro\u0026lt;/em\u0026gt; and \u0026lt;em\u0026gt;in vivo\u0026lt;/em\u0026gt; DMPK studies\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Proven ability to analyze and interpret DMPK data to inform drug development decisions\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Excellent communication, interpersonal, and collaboration skills\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in managing CROs and external partnerships\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must be willing to work onsite 5 days a week\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Nice To Have:\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Experience with a variety of therapeutic modalities, including small molecules,\u0026amp;nbsp; biologics, and peptides\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Familiarity with regulatory guidelines and requirements for DMPK studies\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Prior experience in writing regulatory documents is highly desirable\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with modeling and simulation software such as Phoenix WinNonlin, Gastroplus, SimCYP\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary range for this role is $197,000 - $235,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.\u0026lt;/p\u0026gt;\n\u0026lt;h2 id=\u0026quot;ojxVC\u0026quot; class=\u0026quot;wLzlc\u0026quot;\u0026gt;\u0026lt;/h2\u0026gt;","departments":[{"id":4126314002,"name":"DRUG DISCOVERY","child_ids":[],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8348828002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6334021002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8348828002,"updated_at":"2026-09-03T18:51:02-04:00","requisition_id":"744","title":"Senior / Principal Scientist, Antibody Engineering \u0026 Rational Design","company_name":"Calico ","first_published":"2025-12-19T19:15:28-05:00","language":"en","application_deadline":null,"content":"\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Who We Are:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Description:\u0026lt;/strong\u0026gt;\u0026amp;nbsp;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;We are seeking an innovative Senior Scientist / Principal Scientist to bridge the gap between traditional antibody discovery and cutting-edge computational design. In this role, you will serve as the primary scientific liaison between the wet-lab antibody team and our machine learning team, driving the evolution of our \u0026quot;Design-Build-Test-Learn\u0026quot; cycle.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;You will be responsible for using internal and external computational tools to generate designs for a variety of discovery campaigns and optimization of antibodies. You will also ensure that the computational predictions are rigorously validated and that the resulting biological data is structured to retrain and refine our internal models. We are looking for a deep expert in therapeutic antibody development who is eager to move beyond traditional random screening and champion a rational, data-driven approach to biologic drug discovery.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Requirements:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Ph.D. in molecular biology, biochemistry, biophysics, computational chemistry, structural biology, or related discipline\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;5+ years’ (for Senior Scientist) or 8+ years (for Principal Scientist) post-PhD experience in antibody/protein engineering within the biotech or biopharma industry\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Demonstrated ability to work closely with data scientists and ML engineers and to articulate biological constraints (\u0026lt;em\u0026gt;e.g.,\u0026lt;/em\u0026gt; immunogenicity, manufacturability) to collaboratively improve model performance\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Hands-on experience using state of the art ML protein design tools (\u0026lt;em\u0026gt;e.g.\u0026lt;/em\u0026gt; AlphaFold, Boltz, RFDiffusion, ProteinMPNN)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Fluency with programming in Python\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Extensive experience in rational design for humanization, affinity/specificity optimization, pH-dependence, and liability removal\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong understanding of biophysical characterization to ensure designed molecules are developable therapeutics\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience technically managing CROs for gene mutagenesis, \u0026lt;em\u0026gt;in vitro\u0026lt;/em\u0026gt; library design, protein production, and screening assays\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Ability to independently propose novel scientific approaches and solve complex technical hurdles\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must be willing to work onsite 5 days a week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Nice to Have:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Experience with structural modeling using molecular dynamics or other physics-based simulation (\u0026lt;em\u0026gt;e.g.\u0026lt;/em\u0026gt; Schrödinger, MOE, Rosetta) to validate and optimize designs\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience designing experiments specifically to generate high-quality training data for ML models (\u0026lt;em\u0026gt;e.g.\u0026lt;/em\u0026gt; focused libraries or systematic mutagenesis for optimization of binding, manufacturability, biophysical properties and stability)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience running computational pipelines for \u0026lt;em\u0026gt;de novo\u0026lt;/em\u0026gt; antibody or VHH design\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Familiarity with common scientific computing and machine learning Python libraries (\u0026lt;em\u0026gt;e.g.\u0026lt;/em\u0026gt; NumPy, SciPy, PyTorch)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with \u0026lt;em\u0026gt;in vivo\u0026lt;/em\u0026gt;\u0026amp;nbsp;and\u0026amp;nbsp;\u0026lt;em\u0026gt;in vitro\u0026lt;/em\u0026gt;\u0026amp;nbsp;discovery of antibodies by display technologies\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience in engineering multi-specific antibodies\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary range for this role is $177,000 - $235,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.\u0026lt;/p\u0026gt;","departments":[{"id":4067318002,"name":"DISCOVERY TECHNOLOGIES","child_ids":[],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8635675002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6448877002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8635675002,"updated_at":"2026-08-20T17:52:23-04:00","requisition_id":"791","title":"Senior / Staff Cloud Platform Engineer (ML)","company_name":"Calico ","first_published":"2026-07-15T16:08:06-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h2\u0026gt;\u0026lt;strong\u0026gt;Who We Are:\u0026lt;/strong\u0026gt;\u0026lt;/h2\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026lt;/p\u0026gt;\n\u0026lt;h2\u0026gt;\u0026lt;strong\u0026gt;Position Description:\u0026lt;/strong\u0026gt;\u0026lt;/h2\u0026gt;\n\u0026lt;p\u0026gt;Calico seeks a Senior / Staff Cloud Engineer to lead the execution and operation of our next-generation machine learning (ML) platform. As the technical authority for our Google Cloud Platform (GCP) environment, you will build infrastructure-as-Code (IaC), design secure perimeters, automate identity management, and migrate existing workflows into a unified, compliant infrastructure.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;If you are passionate about DevSecOps, IaC, and building \u0026quot;paved paths\u0026quot; that empower scientists while enforcing rigorous security, this is the role for you. You will be the critical bridge that allows our ML Systems and Research engineers to train and deploy ML models for frontier BioML research.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Please note: No biology or life sciences background is required for this role.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;You will work with a team of researchers and engineers on Calico’s key strategic cross-functional initiatives through the following responsibilities:\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Foundational Impact:\u0026lt;/strong\u0026gt;\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Deliver our next-generation ML platform\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Lead the consolidation and modernization of our compute environments, and accelerate the whole company\u0026#39;s R\u0026amp;amp;D cycle\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;GCP Foundation:\u0026lt;/strong\u0026gt;\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Lead the centralization of GCP projects into a unified, compliant landing zone\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Design secure perimeters to protect sensitive biological data, and build automated guardrails using Terraform\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;GKE Cluster Administration:\u0026lt;/strong\u0026gt;\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Design, deploy, and maintain robust GKE clusters tailored for distributed ML training and batch processing workloads\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Troubleshoot node-level GPU/TPU issues, manage scheduling add-ons, and optimize cluster autoscaling\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Developer Experience \u0026amp;amp; Onboarding:\u0026lt;/strong\u0026gt;\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Design intuitive onboarding processes and \u0026quot;paved paths\u0026quot; for scientists to seamlessly onboard onto the new platform\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;FinOps:\u0026lt;/strong\u0026gt;\u0026amp;nbsp;\u0026lt;/li\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Manage org-level GPU/TPU compute capacity, implement centralized billing and cost reporting, and build comprehensive monitoring dashboards to track cluster utilization and optimize R\u0026amp;amp;D expenditure\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h2\u0026gt;\u0026lt;strong\u0026gt;Position Requirements:\u0026lt;/strong\u0026gt;\u0026lt;/h2\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;BS/MS with 7+ years or PhD with 4+ years of relevant software engineering, DevSecOps, or Cloud architecture experience\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong programming skills in Python\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong hands-on experience with Google Cloud Platform (GCP) core services\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with Kubernetes cluster administration\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with Terraform, building CI/CD pipelines, and containerization (Docker)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must be willing to work onsite at least four days a week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h2\u0026gt;\u0026lt;strong\u0026gt;Nice to Have:\u0026lt;/strong\u0026gt;\u0026lt;/h2\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;A strong intellectual curiosity for life sciences\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience managing Kubernetes for HPC or ML workloads\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience supporting Machine Learning orchestration and queueing frameworks (e.g., Kueue, Ray)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience reading and debugging ML Python code\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience implementing compliant cloud architectures (e.g., SOC2, HIPAA, or similar frameworks)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Familiarity with Golang\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Strong communication skills with a proven ability to guide users through migration\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary range for this role is $220,000 - $290,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.\u0026lt;/p\u0026gt;","departments":[{"id":4019742002,"name":"COMPUTING","child_ids":[],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null},{"absolute_url":"https://www.calicolabs.com/careers/?gh_jid=8457339002","data_compliance":[{"type":"gdpr","requires_consent":false,"requires_processing_consent":false,"requires_retention_consent":false,"retention_period":null,"demographic_data_consent_applies":false}],"internal_job_id":6378339002,"location":{"name":"South San Francisco, CA"},"metadata":null,"id":8457339002,"updated_at":"2026-09-04T18:23:49-04:00","requisition_id":"773","title":"Senior / Staff Machine Learning Research Engineer","company_name":"Calico ","first_published":"2026-05-05T13:45:18-04:00","language":"en","application_deadline":null,"content":"\u0026lt;h3\u0026gt;\u0026lt;strong\u0026gt;Senior / Staff Machine Learning Research Engineer\u0026amp;nbsp;\u0026lt;/strong\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;strong\u0026gt;Who We Are:\u0026lt;/strong\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico\u0026#39;s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.\u0026lt;/p\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;strong\u0026gt;Position Description:\u0026lt;/strong\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;p\u0026gt;Calico seeks Machine Learning Research Engineers to join our rapidly growing ML team. You will play a critical role establishing the engineering culture for frontier ML research in drug discovery. You will bring a high level of engineering rigor to our machine learning efforts and accelerate our research maturing into tangible clinical and product impact.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;This will be a high agency role designed for a builder who wants to operate as a founding member of a new functional group.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;Please note: No biology or life sciences background is required for this role.\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;\u0026lt;strong\u0026gt;Position Responsibilities:\u0026lt;/strong\u0026gt;\u0026lt;/p\u0026gt;\n\u0026lt;p\u0026gt;You will drive the engineering vision behind our machine learning models, from identifying high-impact ML research opportunities to delivering production-grade systems. Partnering closely with biology-fluent ML researchers and Data Engineers, your responsibilities will span the following areas:\u0026lt;/p\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Advance Foundational ML Capabilities:\u0026lt;/strong\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Translate new ideas and prototype models (e.g., diffusion networks, vision transformers, and DNA sequence models) into highly-optimized and scalable JAX or PyTorch code on accelerators\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Dive deep into model architectures to optimize training and inference performance, implementing advanced strategies such as model parallelism\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Research Engineering:\u0026lt;/strong\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Proactively identify emerging engineering gaps required for expanding our research capabilities\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Architect solutions for complex systems challenges, such as asynchronous execution, hardware orchestration, and high-throughput data pipelines\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Build foundational libraries that enforce software engineering rigor\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;\u0026lt;strong\u0026gt;Force Multiplier:\u0026lt;/strong\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Design and implement evaluation frameworks, benchmarks, and scientific workflow tools that accelerate the company’s whole research lifecycle and allow the team to rapidly test promising ideas\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;strong\u0026gt;Position Requirements:\u0026lt;/strong\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;A strong intellectual curiosity for life sciences\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;BS/MS with 7+ years or PhD with 4+ years of relevant experience\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Expertise in Python and JAX or PyTorch\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Track record of building, training, or optimizing advanced ML architectures (e.g., transformers, diffusion networks, GNNs) from concept to publication or production\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Must be willing to work onsite at least four days a week\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;h3\u0026gt;\u0026lt;strong\u0026gt;Nice to Have:\u0026lt;/strong\u0026gt;\u0026lt;/h3\u0026gt;\n\u0026lt;ul\u0026gt;\n\u0026lt;li\u0026gt;Experience working with biological, medical, or chemistry datasets\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Contributions to open-source ML projects or first-author ML publications\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience training models across distributed systems and optimizing performance\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Experience with cloud infrastructure (e.g., GCP, Kubernetes, Docker)\u0026lt;/li\u0026gt;\n\u0026lt;li\u0026gt;Advanced degree in computer science\u0026lt;/li\u0026gt;\n\u0026lt;/ul\u0026gt;\n\u0026lt;p\u0026gt;The estimated base salary range for this role is $220,000 - $290,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.\u0026lt;/p\u0026gt;","departments":[{"id":4019742002,"name":"COMPUTING","child_ids":[],"parent_id":null}],"offices":[{"id":4002194002,"name":"South San Francisco, CA","location":"South San Francisco, California, United States","child_ids":[],"parent_id":null}],"ai_disclaimer":null,"include_ai_disclaimer":null,"ai_opt_out_request_url":null}],"meta":{"total":16}}